PMID- 37586158
OWN - NLM
STAT- MEDLINE
DCOM- 20230831
LR  - 20230831
IS  - 1618-095X (Electronic)
IS  - 0944-7113 (Linking)
VI  - 119
DP  - 2023 Oct
TI  - Xiao-qing-long-tang ameliorates OVA-induced allergic rhinitis by inhibiting ILC2s 
      through the IL-33/ST2 and JAK/STAT pathways.
PG  - 155012
LID - S0944-7113(23)00373-2 [pii]
LID - 10.1016/j.phymed.2023.155012 [doi]
AB  - BACKGROUND: Allergic rhinitis (AR) is a chronic inflammatory disease of the nasal 
      mucosa that is mediated by immunoglobulin E (IgE). Xiao-qing-long-tang (XQLT) is 
      a traditional Chinese medicine compound that is widely used to treat respiratory 
      diseases such as AR. However, the underlying mechanism of the effect of XQLT on 
      AR remains unclear. PURPOSE: To elucidate the effect of XQLT on ovalbumin 
      (OVA)-induced AR and the mechanisms of action. METHODS: The therapeutic efficacy 
      of XQLT was evaluated in a well-established OVA-induced AR mouse model. Nasal 
      symptoms were analyzed, type 2 cytokines and OVA-sIgE levels were measured, nasal 
      mucosa tissues were collected for histological analysis, and the changes of Group 
      2 innate lymphoid cells (ILC2s) and the IL-33/ST2 and JAK/STAT signaling pathways 
      in the nasal mucosa were observed. RESULTS: XQLT significantly alleviated the 
      nasal symptoms and histological damage to the nasal mucosa in AR mice, and 
      reduced the levels of type 2 cytokines and OVA-sIgE. In addition, after XQLT 
      treatment, the numbers of ILC2s in the nasal mucosa of AR mice were reduced, and 
      the mRNA levels of the transcription factors GATA3 and ROR-alpha were decreased. 
      Moreover, IL-33/ST2 signaling pathway was inhibited. The costimulatory cytokine 
      associated JAK/STAT signaling pathway was also inhibited in ILC2s. CONCLUSION: 
      Our study demonstrated that XQLT regulated ILC2s through the IL-33/ST2 and 
      JAK/STAT pathways to ameliorate type 2 inflammation in OVA-induced AR. These 
      findings suggest that XQLT might be used to treat AR.
CI  - Copyright (c) 2023. Published by Elsevier GmbH.
FAU - Zhang, Jia-Jun
AU  - Zhang JJ
AD  - The First Clinical Medical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, 510405, China; Department of Otorhinolaryngology, the Second People's 
      Hospital of Foshan, Affiliated Foshan Hospital of Southern Medical University, 
      Foshan, Guangdong Province, 528099, China.
FAU - He, Xue-Cheng
AU  - He XC
AD  - The First Clinical Medical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, 510405, China.
FAU - Zhou, Min
AU  - Zhou M
AD  - Otorhinolaryngology Department, the First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, 510405, China.
FAU - Liu, Qin-Dong
AU  - Liu QD
AD  - The First Clinical Medical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, 510405, China.
FAU - Xu, Wei-Zhen
AU  - Xu WZ
AD  - The First Clinical Medical College of Guangzhou University of Chinese Medicine, 
      Guangzhou, 510405, China.
FAU - Yan, Ya-Jie
AU  - Yan YJ
AD  - Otorhinolaryngology Department, the First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, 510405, China; Guangdong Clinical 
      Research Academy of Chinese Medicine, Guangzhou, 510405, China. Electronic 
      address: yajieyan50008@gzucm.edu.cn.
FAU - Ruan, Yan
AU  - Ruan Y
AD  - Otorhinolaryngology Department, the First Affiliated Hospital of Guangzhou 
      University of Chinese Medicine, Guangzhou, 510405, China; Guangdong Clinical 
      Research Academy of Chinese Medicine, Guangzhou, 510405, China. Electronic 
      address: ry0722@gzucm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230806
PL  - Germany
TA  - Phytomedicine
JT  - Phytomedicine : international journal of phytotherapy and phytopharmacology
JID - 9438794
RN  - 9006-59-1 (Ovalbumin)
RN  - 0 (sho-seiryu-to)
RN  - 0 (Interleukin-1 Receptor-Like 1 Protein)
RN  - EC 2.7.10.2 (Janus Kinases)
RN  - 0 (Interleukin-33)
RN  - 0 (STAT Transcription Factors)
RN  - 0 (Cytokines)
SB  - IM
MH  - Animals
MH  - Mice
MH  - Ovalbumin
MH  - *Immunity, Innate
MH  - Interleukin-1 Receptor-Like 1 Protein/metabolism
MH  - Janus Kinases/metabolism
MH  - Interleukin-33/metabolism
MH  - Lymphocytes
MH  - Signal Transduction
MH  - STAT Transcription Factors/metabolism
MH  - *Rhinitis, Allergic/chemically induced/drug therapy
MH  - Cytokines/metabolism
MH  - Disease Models, Animal
MH  - Mice, Inbred BALB C
OTO - NOTNLM
OT  - Allergic rhinitis
OT  - IL-33/ST2 signaling
OT  - ILC2s
OT  - JAK/STAT pathway
OT  - Xiao-qing-long-tang
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/08/17 00:42
MHDA- 2023/08/31 06:42
CRDT- 2023/08/16 18:02
PHST- 2022/10/18 00:00 [received]
PHST- 2023/07/27 00:00 [revised]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2023/08/31 06:42 [medline]
PHST- 2023/08/17 00:42 [pubmed]
PHST- 2023/08/16 18:02 [entrez]
AID - S0944-7113(23)00373-2 [pii]
AID - 10.1016/j.phymed.2023.155012 [doi]
PST - ppublish
SO  - Phytomedicine. 2023 Oct;119:155012. doi: 10.1016/j.phymed.2023.155012. Epub 2023 
      Aug 6.