PMID- 37586707
OWN - NLM
STAT- MEDLINE
DCOM- 20230915
LR  - 20230916
IS  - 1752-699X (Electronic)
IS  - 1752-6981 (Print)
IS  - 1752-6981 (Linking)
VI  - 17
IP  - 9
DP  - 2023 Sep
TI  - Exploration of the minimal clinically important difference value of the 3-min 
      simulated pedal motion in patients with chronic obstructive pulmonary disease: A 
      self-controlled prospective clinical trial.
PG  - 951-961
LID - 10.1111/crj.13687 [doi]
AB  - BACKGROUND: To help elderly patients with severe or very severe chronic 
      obstructive pulmonary disease (COPD) with pulmonary rehabilitation, we have 
      developed Zheng's supine rehabilitation exercise (ZSRE). Currently, none of the 
      terminal or critically ill patients with severe exercise limitation can complete 
      the 6-min walking distance (6MWD) and cardiopulmonary exercise testing (CPET). 
      METHODS: In this study, we discuss the definition of the standardized 3-min 
      simulated pedal motion (3MSPM) test and its operational specifications. Also, we 
      evaluate the minimal clinically important difference (MCID) value of the 3MSPM. 
      RESULTS: The results showed that the mMRC score of COPD patients with acute 
      exacerbation of dyspnea was progressively reduced from the second day of 
      respiratory rehabilitation, and the difference between the first and seventh days 
      was statistically significant (p < 0.000, chi(2)  = 176.664). 6MWD increased 
      progressively, and the difference between 6MWD on day 1-7 was statistically 
      significant (p = 0.024, F = 2.443). The difference between 3MSPM on day 1-7 was 
      also statistically significant (p < 0.000, F = 4.481). Further analysis showed 
      that 6MWD was negatively correlated with mMRC (p < 0.000, OR = -0.524). 3MSPM was 
      positively correlated with 6MWD (p < 0.000, OR = 0.640) but negatively correlated 
      with mMRC (p < 0.000, OR = -0.413). There is a linear regression relationship 
      between 6MWD and 3MSPM, that is, 6MWD = 14.151 + 0.301 * 3MSPM, adjusted R(2) 
       = 0.401. CONCLUSION: Based on the regression equation, 3MSPM can predict 6MWD, 
      and it can be used as a simple exercise endurance method to evaluate patients 
      with safety hazards in underground activities or who cannot complete the 6MWD 
      test. The minimum clinically important difference value is increased by 23.
CI  - (c) 2023 The Authors. The Clinical Respiratory Journal published by John Wiley & 
      Sons Ltd.
FAU - Zhang, Xiaoting
AU  - Zhang X
AD  - Zhengzhou Central Hospital Affiliated to Zhengzhou University, Zhengzhou, Henan, 
      China.
FAU - Liu, Ni
AU  - Liu N
AUID- ORCID: 0000-0003-1024-305X
AD  - State Key Laboraory of Respiratory Disease, National Clinical Research Center for 
      Respiratory Disease, Guangzhou Institute of Respiratory Health, The First 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Yang, Feng
AU  - Yang F
AD  - State Key Laboraory of Respiratory Disease, National Clinical Research Center for 
      Respiratory Disease, Guangzhou Institute of Respiratory Health, The First 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Su, Guansheng
AU  - Su G
AUID- ORCID: 0000-0002-6164-5721
AD  - State Key Laboraory of Respiratory Disease, National Clinical Research Center for 
      Respiratory Disease, Guangzhou Institute of Respiratory Health, The First 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Hu, Jieying
AU  - Hu J
AD  - State Key Laboraory of Respiratory Disease, National Clinical Research Center for 
      Respiratory Disease, Guangzhou Institute of Respiratory Health, The First 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
FAU - Chen, Rongchang
AU  - Chen R
AD  - Shenzhen Institute of Respiratory Diseases, Shenzhen City, Guangdong province, 
      China.
FAU - Zheng, Zeguang
AU  - Zheng Z
AD  - State Key Laboraory of Respiratory Disease, National Clinical Research Center for 
      Respiratory Disease, Guangzhou Institute of Respiratory Health, The First 
      Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China.
LA  - eng
GR  - 202201020513/Guangzhou Science and Technology Plans/
GR  - 202201020435/Guangzhou Science and Technology Plans/
GR  - [2021]56/First Affiliated Hospital of Guangzhou Medical University Plans/
PT  - Journal Article
DEP - 20230816
PL  - England
TA  - Clin Respir J
JT  - The clinical respiratory journal
JID - 101315570
SB  - IM
MH  - Humans
MH  - Aged
MH  - Prospective Studies
MH  - *Minimal Clinically Important Difference
MH  - *Pulmonary Disease, Chronic Obstructive
MH  - Exercise Test
MH  - Exercise
MH  - Exercise Tolerance
PMC - PMC10500321
OTO - NOTNLM
OT  - 3MSPM
OT  - 6MWD
OT  - chronic obstructive pulmonary disease
OT  - exercise therapy
OT  - pulmonary rehabilitation
COIS- We declare that we have no conflict of interest.
EDAT- 2023/08/17 00:42
MHDA- 2023/09/15 06:43
PMCR- 2023/08/16
CRDT- 2023/08/16 20:03
PHST- 2023/05/30 00:00 [revised]
PHST- 2022/11/27 00:00 [received]
PHST- 2023/08/03 00:00 [accepted]
PHST- 2023/09/15 06:43 [medline]
PHST- 2023/08/17 00:42 [pubmed]
PHST- 2023/08/16 20:03 [entrez]
PHST- 2023/08/16 00:00 [pmc-release]
AID - CRJ13687 [pii]
AID - 10.1111/crj.13687 [doi]
PST - ppublish
SO  - Clin Respir J. 2023 Sep;17(9):951-961. doi: 10.1111/crj.13687. Epub 2023 Aug 16.