PMID- 37587033
OWN - NLM
STAT- MEDLINE
DCOM- 20231116
LR  - 20240318
IS  - 1758-5368 (Electronic)
IS  - 1079-5014 (Linking)
VI  - 78
IP  - 11
DP  - 2023 Nov 14
TI  - Brain Connectivity Correlates of Cognitive Dispersion in a Healthy Middle-Aged 
      Population: Influence of Subjective Cognitive Complaints.
PG  - 1860-1869
LID - 10.1093/geronb/gbad114 [doi]
AB  - OBJECTIVES: Cognitive dispersion, representing intraindividual fluctuations in 
      cognitive performance, is associated with cognitive decline in advanced age. We 
      sought to elucidate sociodemographic, neuropsychological, and brain connectivity 
      correlates of cognitive dispersion in middle age, and further consider potential 
      influences of the severity of subjective cognitive complaints (SCC). METHODS: 
      Five hundred and twenty healthy volunteers from the Barcelona Brain Health 
      Initiative (aged 40-66 years; 49.6% females, 453 with magnetic resonance imaging 
      acquisitions) were included and stratified into high and low SCC groups. Two 
      analysis steps were undertaken: (1) for the whole sample and (2) by groups. 
      Generalized linear models and analysis of covariance were implemented to study 
      associations between cognitive dispersion and performance (episodic memory, speed 
      of processing, and executive function), white matter integrity, and resting-state 
      functional connectivity (rs-FC) of the default mode network (DMN) and dorsal 
      attentional networks (DAN). RESULTS: Across-domain dispersion was negatively 
      related to cognitive performance, rs-FC within the DMN, and between the DMN and 
      the DAN, but not to white matter integrity. The rs-FC values were not explained 
      by cognitive performance. When considering groups, the above findings were 
      significant only for those with high SCC. DISCUSSION: In healthy middle-aged 
      individuals, high cognitive dispersion was related to poorer cognition and DMN 
      dysregulation, being these associations stronger among subjects with high SCC. 
      The present results reinforce the interest in considering dispersion measures 
      within neuropsychological evaluations, as they may be more sensitive to incipient 
      age-related cognitive and functional brain changes than traditional measures of 
      performance.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Mulet-Pons, Lidia
AU  - Mulet-Pons L
AUID- ORCID: 0000-0002-8884-136X
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
FAU - Sole-Padulles, Cristina
AU  - Sole-Padulles C
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
FAU - Cabello-Toscano, Maria
AU  - Cabello-Toscano M
AUID- ORCID: 0000-0001-5066-3476
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
AD  - Guttmann Institute, Institut Universitari de Neurorehabilitacio adscrit a la 
      Universitat Autonoma de Barcelona, Badalona, Spain.
FAU - Abellaneda-Perez, Kilian
AU  - Abellaneda-Perez K
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
AD  - Guttmann Institute, Institut Universitari de Neurorehabilitacio adscrit a la 
      Universitat Autonoma de Barcelona, Badalona, Spain.
FAU - Perellon-Alfonso, Ruben
AU  - Perellon-Alfonso R
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
FAU - Cattaneo, Gabriele
AU  - Cattaneo G
AD  - Guttmann Institute, Institut Universitari de Neurorehabilitacio adscrit a la 
      Universitat Autonoma de Barcelona, Badalona, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Badalona, Spain.
FAU - Solana Sanchez, Javier
AU  - Solana Sanchez J
AD  - Guttmann Institute, Institut Universitari de Neurorehabilitacio adscrit a la 
      Universitat Autonoma de Barcelona, Badalona, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Badalona, Spain.
FAU - Alviarez-Schulze, Vanessa
AU  - Alviarez-Schulze V
AD  - Guttmann Institute, Institut Universitari de Neurorehabilitacio adscrit a la 
      Universitat Autonoma de Barcelona, Badalona, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Badalona, Spain.
FAU - Bargallo, Nuria
AU  - Bargallo N
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
AD  - Neuroradiology Section, Radiology Department, Diagnostic Image Center, Hospital 
      Clinic of Barcelona, University of Barcelona, Barcelona, Spain.
FAU - Tormos-Munoz, Josep M feminine
AU  - Tormos-Munoz JM
AD  - Guttmann Institute, Institut Universitari de Neurorehabilitacio adscrit a la 
      Universitat Autonoma de Barcelona, Badalona, Spain.
AD  - Centro de Investigacion Traslacional San Alberto Magno, Universidad Catolica de 
      Valencia San Vicente Martir, Valencia, Spain.
FAU - Pascual-Leone, Alvaro
AU  - Pascual-Leone A
AD  - Hinda and Arthur Marcus Institute for Aging Research and Deanna and Sidney Wolk 
      Center for Memory Health, Hebrew SeniorLife, Harvard Medical School, Boston, 
      Massachusetts, USA.
AD  - Department of Neurology, Harvard Medical School, Boston, Massachusetts, USA.
FAU - Bartres-Faz, David
AU  - Bartres-Faz D
AUID- ORCID: 0000-0001-6020-4118
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
AD  - Guttmann Institute, Institut Universitari de Neurorehabilitacio adscrit a la 
      Universitat Autonoma de Barcelona, Badalona, Spain.
FAU - Vaque-Alcazar, Lidia
AU  - Vaque-Alcazar L
AUID- ORCID: 0000-0002-6776-6559
AD  - Department of Medicine, Faculty of Medicine and Health Sciences, Institute of 
      Neurosciences, University of Barcelona, Institut d'Investigacions Biomediques 
      August Pi i Sunyer (IDIBAPS), Barcelona, Spain.
AD  - Sant Pau Memory Unit, Department of Neurology, Institut d'Investigacions 
      Biomediques Sant Pau-Hospital de Sant Pau, Universitat Autonoma de Barcelona, 
      Barcelona, Spain.
LA  - eng
GR  - LCF/BQ/DI19/11730050/"La Caixa" Foundation/
GR  - Institut Guttmann and Fundacio Abertis/
GR  - RTI2018-095181-B-C21/Spanish Ministry of Science, Innovation and Universities/
GR  - 2020PANDE00043/Agencia de Gestio d'Ajuts Universitaris i de Recerca/
GR  - 202129-31/"La Marato de TV3" Foundation/
GR  - RTI2018-095181-B-C21/Spanish Ministry of Science, Innovation and Universities/
GR  - FJC2021-047380-I/Juan de la Cierva-Formacion research/
GR  - PROD 00172/Agencia de Gestio d'Ajuts Universitaris i de Recerca/
GR  - Fundacio Joan Ribas Araquistain/
GR  - 201735.10/"La Marato de TV3" Foundation/
GR  - UNI/551/2021/Margarita Salas postdoctoral fellowship/
GR  - 2021SGR00801/Government of Catalonia/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Gerontol B Psychol Sci Soc Sci
JT  - The journals of gerontology. Series B, Psychological sciences and social sciences
JID - 9508483
SB  - IM
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Male
MH  - *Brain/diagnostic imaging/pathology
MH  - *Cognitive Dysfunction/pathology
MH  - Magnetic Resonance Imaging
MH  - Brain Mapping
MH  - Neuropsychological Tests
MH  - Cognition/physiology
OTO - NOTNLM
OT  - Cognition
OT  - Neuroimaging
OT  - Neuropsychology
EDAT- 2023/08/17 00:42
MHDA- 2023/11/16 06:45
CRDT- 2023/08/16 22:13
PHST- 2023/03/09 00:00 [received]
PHST- 2023/11/16 06:45 [medline]
PHST- 2023/08/17 00:42 [pubmed]
PHST- 2023/08/16 22:13 [entrez]
AID - 7243426 [pii]
AID - 10.1093/geronb/gbad114 [doi]
PST - ppublish
SO  - J Gerontol B Psychol Sci Soc Sci. 2023 Nov 14;78(11):1860-1869. doi: 
      10.1093/geronb/gbad114.