PMID- 37587127
OWN - NLM
STAT- MEDLINE
DCOM- 20230818
LR  - 20231118
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Aug 16
TI  - Active surveillance for adverse events of influenza vaccine safety in elderly 
      cancer patients using self-controlled tree-temporal scan statistic analysis.
PG  - 13346
LID - 10.1038/s41598-023-40091-y [doi]
LID - 13346
AB  - Both cancer patients and the elderly are at high risk of developing flu 
      complications, so influenza vaccination is recommended. We aimed to evaluate 
      potential adverse events (AEs) following influenza vaccination in elderly cancer 
      patients using the self-controlled tree-temporal scan statistic method. From a 
      large linked database of Korea Disease Control and Prevention Agency vaccination 
      data and the National Health Insurance Service claims data, we identified cancer 
      patients aged over 65 who received flu vaccines during the 2016/2017 and 
      2017/2018 seasons. We included all the outcomes occurring on 1-84 days 
      post-vaccination and evaluated all temporal risk windows, which started 1-28 days 
      and ended 2-42 days. Patients who were diagnosed with the same disease during a 
      year prior to vaccination were excluded. We used the hierarchy of ICD-10 to 
      identify statistically significant clustering. This study included 431,276 doses 
      of flu vaccine. We detected signals for 1 set: other dorsopathies on 1-15 days 
      (attributable risk 16.5 per 100,000, P = 0.017). Dorsopathy is a known AE of 
      influenza vaccine. No statistically significant clusters were found when analyzed 
      by flu season. Therefore, influenza vaccination is more recommended for elderly 
      patients with cancer and weakened immune systems.
CI  - (c) 2023. Springer Nature Limited.
FAU - Jeong, Na-Young
AU  - Jeong NY
AD  - Department of Health Convergence, College of Science & Industry Convergence, Ewha 
      Womans University, Seoul, Korea.
FAU - Kim, Chung-Jong
AU  - Kim CJ
AD  - Department of Internal Medicine, Ewha Womans University Seoul Hospital, Seoul, 
      Korea.
FAU - Park, Sang Min
AU  - Park SM
AD  - Department of Family Medicine, Seoul National University Hospital, Seoul, Korea.
AD  - Department of Biomedical Sciences, Seoul National University Graduate School, 
      Seoul National University College of Medicine, Seoul, Korea.
FAU - Kim, Ye-Jee
AU  - Kim YJ
AD  - Department of Clinical Epidemiology and Biostatistics, Asan Medical Center, 
      University of Ulsan College of Medicine, Seoul, Korea.
FAU - Lee, Joongyub
AU  - Lee J
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, Korea.
FAU - Choi, Nam-Kyong
AU  - Choi NK
AD  - Department of Health Convergence, College of Science & Industry Convergence, Ewha 
      Womans University, Seoul, Korea. nchoi@ewha.ac.kr.
AD  - Graduate School of Industrial Pharmaceutical Science, College of Pharmacy, Ewha 
      Womans University, Seoul, Korea. nchoi@ewha.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230816
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Influenza Vaccines)
SB  - IM
MH  - Aged
MH  - Humans
MH  - *Influenza Vaccines/adverse effects
MH  - *Influenza, Human/prevention & control
MH  - Trees
MH  - Watchful Waiting
MH  - *Neoplasms/epidemiology
MH  - *Spinal Diseases
PMC - PMC10432531
COIS- The authors declare no competing interests.
EDAT- 2023/08/17 00:42
MHDA- 2023/08/18 06:43
PMCR- 2023/08/16
CRDT- 2023/08/16 23:18
PHST- 2023/04/27 00:00 [received]
PHST- 2023/08/04 00:00 [accepted]
PHST- 2023/08/18 06:43 [medline]
PHST- 2023/08/17 00:42 [pubmed]
PHST- 2023/08/16 23:18 [entrez]
PHST- 2023/08/16 00:00 [pmc-release]
AID - 10.1038/s41598-023-40091-y [pii]
AID - 40091 [pii]
AID - 10.1038/s41598-023-40091-y [doi]
PST - epublish
SO  - Sci Rep. 2023 Aug 16;13(1):13346. doi: 10.1038/s41598-023-40091-y.