PMID- 37588991 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230818 IS - 2221-285X (Electronic) IS - 1818-0876 (Print) IS - 1818-0876 (Linking) VI - 18 IP - 4 DP - 2023 Jul TI - High drug loading hydrophobic cross-linked dextran microspheres as novel drug delivery systems for the treatment of osteoarthritis. PG - 100830 LID - 10.1016/j.ajps.2023.100830 [doi] LID - 100830 AB - Drug delivery via intra-articular (IA) injection has proved to be effective in osteoarthritis (OA) therapy, limited by the drug efficiency and short retention time of the drug delivery systems (DDSs). Herein, a series of modified cross-linked dextran (Sephadex, S0) was fabricated by respectively grafting with linear alkyl chains, branched alkyl chains or aromatic chain, and acted as DDSs after ibuprofen (Ibu) loading for OA therapy. This DDSs expressed sustained drug release, excellent anti-inflammatory and chondroprotective effects both in IL-1beta induced chondrocytes and OA joints. Specifically, the introduction of a longer hydrophobic chain, particularly an aromatic chain, distinctly improved the hydrophobicity of S0, increased Ibu loading efficiency, and further led to significantly improving OA therapeutic effects. Therefore, hydrophobic microspheres with greatly improved drug loading ratio and prolonged degradation rates show great potential to act as DDSs for OA therapy. CI - (c) 2023 Published by Elsevier B.V. on behalf of Shenyang Pharmaceutical University. FAU - Li, Zhimin AU - Li Z AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. AD - Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. FAU - Feng, Xianjing AU - Feng X AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. FAU - Luo, Shixing AU - Luo S AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. AD - Department of Orthopedics, The Ninth Affiliated Hospital of Guangxi Medical University, Beihai, Guangxi 536000, China. FAU - Ding, Yanfeng AU - Ding Y AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. AD - Department of Spine and Osteopathic Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. FAU - Zhang, Zhi AU - Zhang Z AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. AD - Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. FAU - Shang, Yifeng AU - Shang Y AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. FAU - Lei, Doudou AU - Lei D AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. FAU - Cai, Jinhong AU - Cai J AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. FAU - Zhao, Jinmin AU - Zhao J AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. AD - Department of Orthopaedics Trauma and Hand Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. FAU - Zheng, Li AU - Zheng L AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. AD - Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. FAU - Gao, Ming AU - Gao M AD - Guangxi Engineering Center in Biomedical Materials for Tissue and Organ Regeneration, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. AD - Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co- constructed by the Province and Ministry, Guangxi Medical University, Nanning 530021, China. AD - Guangxi Key Laboratory of Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. LA - eng PT - Journal Article DEP - 20230725 PL - Netherlands TA - Asian J Pharm Sci JT - Asian journal of pharmaceutical sciences JID - 101535338 PMC - PMC10425896 OTO - NOTNLM OT - Drug delivery system OT - High drug loading ratio OT - Hydrophobic modification OT - Osteoarthritis OT - Sephadex microsphere COIS- The authors declare that no potential conflicts of interest were disclosed. EDAT- 2023/08/17 06:43 MHDA- 2023/08/17 06:44 PMCR- 2023/07/25 CRDT- 2023/08/17 04:29 PHST- 2022/07/07 00:00 [received] PHST- 2023/07/03 00:00 [revised] PHST- 2023/07/06 00:00 [accepted] PHST- 2023/08/17 06:44 [medline] PHST- 2023/08/17 06:43 [pubmed] PHST- 2023/08/17 04:29 [entrez] PHST- 2023/07/25 00:00 [pmc-release] AID - S1818-0876(23)00057-0 [pii] AID - 100830 [pii] AID - 10.1016/j.ajps.2023.100830 [doi] PST - ppublish SO - Asian J Pharm Sci. 2023 Jul;18(4):100830. doi: 10.1016/j.ajps.2023.100830. Epub 2023 Jul 25.