PMID- 37589022 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230928 IS - 2730-5848 (Electronic) IS - 2730-583X (Print) IS - 2730-583X (Linking) VI - 3 IP - 4 DP - 2023 Aug TI - DBLiPro: A Database for Lipids and Proteins in Human Lipid Metabolism. PG - 350-359 LID - 10.1007/s43657-023-00099-w [doi] AB - To help researchers in the field of biology, medicine, chemistry, and materials science to use lipidomic data conveniently, there is an urgent need to develop a platform that provides a systematic knowledgebase of human lipid metabolism and lipidome-centric omics analysis tools. DBLiPro is a user-friendly webserver allowing for access to human metabolism-related lipids and proteins knowledge database and an interactive bioinformatics integrative analysis workflow for lipidomics, transcriptomics, and proteomics data. In DBLiPro, there are 3109 lipid-associated proteins (LAPs) and 2098 lipid metabolites in the knowledge base section, which were obtained from Uniprot, Kyoto Encyclopedia of Genes and Genomes (KEGG) and were further annotated by information from other public resources in the knowledge base section, such as RaftProt and PubChem. DBLiPro offers a step-by-step interactive analysis workflow for lipidomics, transcriptomics, proteomics, and their integrating multi-omics analysis focusing on the human lipid metabolism. In summary, DBLiPro is capable of helping users discover key molecules (lipids and proteins) in human lipid metabolism and investigate lipid-protein functions underlying mechanisms based on their own omics data. The DBLiPro is freely available at http://lipid.cloudna.cn/home. CI - (c) International Human Phenome Institutes (Shanghai) 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. FAU - Wu, Qian AU - Wu Q AUID- ORCID: 0000-0002-1164-6582 AD - NHC Key Laboratory of Reproduction Regulation & Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan University, No. 779, Old Hu Min Road, Shanghai, 200237 China. GRID: grid.8547.e. ISNI: 0000 0001 0125 2443 AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Huang, Yuanyuan AU - Huang Y AUID- ORCID: 0000-0002-6732-2835 AD - Beijing Cloudna Technology Co., Ltd., No. 53, Yanqi Street, Beijing, 100101 China. AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Kong, Xiangya AU - Kong X AUID- ORCID: 0000-0001-9230-878X AD - Beijing Cloudna Technology Co., Ltd., No. 53, Yanqi Street, Beijing, 100101 China. AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Jia, Ben AU - Jia B AUID- ORCID: 0000-0001-5859-8242 AD - NHC Key Laboratory of Reproduction Regulation & Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan University, No. 779, Old Hu Min Road, Shanghai, 200237 China. GRID: grid.8547.e. ISNI: 0000 0001 0125 2443 AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Lu, Xiaoting AU - Lu X AUID- ORCID: 0000-0002-4720-8461 AD - NHC Key Laboratory of Reproduction Regulation & Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan University, No. 779, Old Hu Min Road, Shanghai, 200237 China. GRID: grid.8547.e. ISNI: 0000 0001 0125 2443 AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Chen, Yunqin AU - Chen Y AUID- ORCID: 0000-0002-8619-0890 AD - NHC Key Laboratory of Reproduction Regulation & Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan University, No. 779, Old Hu Min Road, Shanghai, 200237 China. GRID: grid.8547.e. ISNI: 0000 0001 0125 2443 AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Huang, Zechi AU - Huang Z AUID- ORCID: 0000-0001-5454-5733 AD - Beijing Cloudna Technology Co., Ltd., No. 53, Yanqi Street, Beijing, 100101 China. AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Li, Yuan-Yuan AU - Li YY AUID- ORCID: 0000-0001-8755-4695 AD - NHC Key Laboratory of Reproduction Regulation & Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan University, No. 779, Old Hu Min Road, Shanghai, 200237 China. GRID: grid.8547.e. ISNI: 0000 0001 0125 2443 AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. FAU - Dai, Wentao AU - Dai W AUID- ORCID: 0000-0002-0762-919X AD - NHC Key Laboratory of Reproduction Regulation & Shanghai-MOST Key Laboratory of Health and Disease Genomics, Shanghai Institute for Biomedical and Pharmaceutical Technologies (SIBPT), Fudan University, No. 779, Old Hu Min Road, Shanghai, 200237 China. GRID: grid.8547.e. ISNI: 0000 0001 0125 2443 AD - Shanghai Key Laboratory of Gastric Neoplasms, Department of General Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025 China. GRID: grid.412277.5. ISNI: 0000 0004 1760 6738 AD - Shanghai Engineering Research Center of Pharmaceutical Translation, Shanghai, 201203 China. LA - eng PT - Journal Article DEP - 20230516 PL - Switzerland TA - Phenomics JT - Phenomics (Cham, Switzerland) JID - 9918351171706676 PMC - PMC10425311 OTO - NOTNLM OT - Database OT - Human lipid metabolism OT - Lipid OT - Lipid-associated proteins OT - Omics COIS- Conflict of InterestAll of authors declare no competing interests. EDAT- 2023/08/17 06:43 MHDA- 2023/08/17 06:44 PMCR- 2024/08/01 CRDT- 2023/08/17 04:30 PHST- 2022/08/20 00:00 [received] PHST- 2023/02/09 00:00 [revised] PHST- 2023/02/14 00:00 [accepted] PHST- 2024/08/01 00:00 [pmc-release] PHST- 2023/08/17 06:44 [medline] PHST- 2023/08/17 06:43 [pubmed] PHST- 2023/08/17 04:30 [entrez] AID - 99 [pii] AID - 10.1007/s43657-023-00099-w [doi] PST - epublish SO - Phenomics. 2023 May 16;3(4):350-359. doi: 10.1007/s43657-023-00099-w. eCollection 2023 Aug.