PMID- 37591903
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20231121
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Aug 17
TI  - The effects of the NMDAR co-agonist D-serine on the structure and function of 
      optic tectal neurons in the developing visual system.
PG  - 13383
LID - 10.1038/s41598-023-39951-4 [doi]
LID - 13383
AB  - The N-methyl-D-aspartate type glutamate receptor (NMDAR) is a molecular 
      coincidence detector which converts correlated patterns of neuronal activity into 
      cues for the structural and functional refinement of developing circuits in the 
      brain. D-serine is an endogenous co-agonist of the NMDAR. We investigated the 
      effects of potent enhancement of NMDAR-mediated currents by chronic 
      administration of saturating levels of D-serine on the developing Xenopus 
      retinotectal circuit. Chronic exposure to the NMDAR co-agonist D-serine resulted 
      in structural and functional changes in the optic tectum. In immature tectal 
      neurons, D-serine administration led to more compact and less dynamic tectal 
      dendritic arbors, and increased synapse density. Calcium imaging to examine 
      retinotopy of tectal neurons revealed that animals raised in D-serine had more 
      compact visual receptive fields. These findings provide insight into how the 
      availability of endogenous NMDAR co-agonists like D-serine at glutamatergic 
      synapses can regulate the refinement of circuits in the developing brain.
CI  - (c) 2023. Springer Nature Limited.
FAU - Chorghay, Zahraa
AU  - Chorghay Z
AD  - Montreal Neurological Institute-Hospital and Department of Neurology and 
      Neurosurgery, McGill University, 3801 Rue University, Montreal, QC, H3A 2B4, 
      Canada.
FAU - Li, Vanessa J
AU  - Li VJ
AD  - Montreal Neurological Institute-Hospital and Department of Neurology and 
      Neurosurgery, McGill University, 3801 Rue University, Montreal, QC, H3A 2B4, 
      Canada.
FAU - Schohl, Anne
AU  - Schohl A
AD  - Montreal Neurological Institute-Hospital and Department of Neurology and 
      Neurosurgery, McGill University, 3801 Rue University, Montreal, QC, H3A 2B4, 
      Canada.
FAU - Ghosh, Arna
AU  - Ghosh A
AD  - MILA, 6666 Rue St Urbain, Montreal, QC, H2S 3H1, Canada.
FAU - Ruthazer, Edward S
AU  - Ruthazer ES
AD  - Montreal Neurological Institute-Hospital and Department of Neurology and 
      Neurosurgery, McGill University, 3801 Rue University, Montreal, QC, H3A 2B4, 
      Canada. edward.ruthazer@mcgill.ca.
LA  - eng
GR  - FDN-143238/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230817
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 3KX376GY7L (Glutamic Acid)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 452VLY9402 (Serine)
SB  - IM
MH  - Animals
MH  - *Superior Colliculi
MH  - *Neurons
MH  - Tectum Mesencephali
MH  - Glutamic Acid/pharmacology
MH  - Receptors, N-Methyl-D-Aspartate
MH  - Serine
PMC - PMC10435543
COIS- The authors declare no competing interests.
EDAT- 2023/08/18 00:42
MHDA- 2023/08/21 06:42
PMCR- 2023/08/17
CRDT- 2023/08/17 23:20
PHST- 2023/03/27 00:00 [received]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/08/18 00:42 [pubmed]
PHST- 2023/08/17 23:20 [entrez]
PHST- 2023/08/17 00:00 [pmc-release]
AID - 10.1038/s41598-023-39951-4 [pii]
AID - 39951 [pii]
AID - 10.1038/s41598-023-39951-4 [doi]
PST - epublish
SO  - Sci Rep. 2023 Aug 17;13(1):13383. doi: 10.1038/s41598-023-39951-4.