PMID- 37592108
OWN - NLM
STAT- MEDLINE
DCOM- 20230922
LR  - 20230922
IS  - 1432-1211 (Electronic)
IS  - 0093-7711 (Linking)
VI  - 75
IP  - 5
DP  - 2023 Oct
TI  - Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han.
PG  - 445-454
LID - 10.1007/s00251-023-01316-6 [doi]
AB  - Regulating natural killer (NK) cell responses in hematological malignancies 
      largely depend on molecular interactions between killer cell immunoglobulin-like 
      receptors (KIR) and human leukocyte antigen (HLA) class I ligands. The goal of 
      the current study was to examine the key functions of KIR genes, gene 
      combinations of KIR-HLA, and KIR genotypes in genetic predisposition to aplastic 
      anemia (AA). Herein, the genotyping of 16 KIR genes and HLA-A, -B, and -C ligands 
      were performed in 72 AA patients and 150 healthy controls using PCR evaluations 
      with sequence-specific primers using standard assays. According to the obtained 
      results, AA patients had an increased incidence of activating KIR and KIR2DS4 
      (P = 0.465 x 10(-4), Pc = 0.837 x 10(-3), OR = 20.81, 95% CI = 2.786-155.5) 
      compared to controls. KIR/HLA class I ligand profile KIR2DS4/C1 
      (P = 0.350 x 10(-4), Pc = 0.630 x 10(-3), OR = 8.944, 95% CI = 2.667-29.993) was 
      significantly elevated in AA patients compared to healthy controls. Genotype AA1 
      (P = 0.003, OR = 2.351, 95% CI = 1.325-4.172) were increased, and AA195 
      (P = 0.006, OR = 0.060, 95% CI = 0.004-1.023) was decreased among AA cases 
      compared to controls. Our findings indicated that KIR2DS4 may play a role in the 
      pathogenesis of AA. This study revealed the contribution of KIR genes in the 
      etiology of AA cases.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Wang, Tianju
AU  - Wang T
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China.
FAU - Qi, Jun
AU  - Qi J
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China. qijun0802@163.com.
FAU - Wang, Manni
AU  - Wang M
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China.
FAU - Xu, Hua
AU  - Xu H
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China.
FAU - Wu, Junhua
AU  - Wu J
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China.
FAU - Shang, Lixia
AU  - Shang L
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China.
FAU - Chen, Le
AU  - Chen L
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China.
FAU - Li, Yuhui
AU  - Li Y
AD  - HLA Typing Laboratory, Blood Center of the Shaanxi Province, Institute of Xi'an 
      Blood Bank, Xi'an, Shaanxi, 710061, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230817
PL  - United States
TA  - Immunogenetics
JT  - Immunogenetics
JID - 0420404
RN  - 0 (Ligands)
RN  - 0 (Histocompatibility Antigens)
RN  - 0 (HLA Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Humans
MH  - Ligands
MH  - *Anemia, Aplastic/genetics
MH  - Histocompatibility Antigens
MH  - HLA Antigens
MH  - Histocompatibility Antigens Class II
OTO - NOTNLM
OT  - Aplastic anemia (AA)
OT  - Gene polymorphism
OT  - HLA
OT  - KIR genes
EDAT- 2023/08/18 00:42
MHDA- 2023/09/22 06:42
CRDT- 2023/08/17 23:34
PHST- 2023/03/23 00:00 [received]
PHST- 2023/07/15 00:00 [accepted]
PHST- 2023/09/22 06:42 [medline]
PHST- 2023/08/18 00:42 [pubmed]
PHST- 2023/08/17 23:34 [entrez]
AID - 10.1007/s00251-023-01316-6 [pii]
AID - 10.1007/s00251-023-01316-6 [doi]
PST - ppublish
SO  - Immunogenetics. 2023 Oct;75(5):445-454. doi: 10.1007/s00251-023-01316-6. Epub 
      2023 Aug 17.