PMID- 37592207
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20231118
IS  - 1471-2261 (Electronic)
IS  - 1471-2261 (Linking)
VI  - 23
IP  - 1
DP  - 2023 Aug 17
TI  - Prevalence, clinical characteristics and echocardiographic parameters of 
      arrhythmias among patients with rheumatic heart disease attending Jakaya Kikwete 
      Cardiac Institute: a prospective cohort study.
PG  - 403
LID - 10.1186/s12872-023-03427-0 [doi]
LID - 403
AB  - BACKGROUND: Arrhythmia is a known complication of rheumatic heart disease (RHD). 
      It is critical to recognize arrhythmias early on so that prompt preventative 
      actions and vigilant monitoring may be considered while treating these patients. 
      AIM: This study aimed at determining the prevalence, clinical characteristics and 
      echocardiographic parameters of arrhythmias among RHD patients attending Jakaya 
      Kikwete Cardiac Institute (JKCI). METHODOLOGY: Hospital-based cross-sectional 
      study was conducted among 390 patients with an echocardiographic diagnosis of RHD 
      aged 18years and above attending JKCI. Demographic and clinical information was 
      documented. Echocardiography, a resting electrocardiography and 24 h ambulatory 
      Holter monitoring electrocardiography were done. Chi square test was used to 
      determine association between variables and those with a p value </= 0.2 were 
      entered in a multivariate logistic regression analysis to determine the 
      independent factors associated with arrhythmias. P value of < 0.05 was considered 
      statistically significant. The receiver operating curve was used to determine the 
      critical point for left atrial size beyond which arrhythmias develop. RESULTS: A 
      total of 390 patients were included in the analysis. The median age was 39 years 
      interquartile range (IQR 30-52). Females were 257/390 (65.9%). Asymptomatic 
      patients were 208/390 (53.3%). Most patients belonged to New York heart 
      Association (NYHA) functional class I&II 247/390 (62.1%). The most common valve 
      lesion was mitral stenosis 228/390 (58.5%). Arrhythmias were found in 276/390 
      (70.77%) patients, of which 193/390 (49.5%) patients were from resting 
      electrocardiography (ECG) and 88/197 (44.7%) patients from holter ECG. 
      Independent factors for arrhythmias were, NYHA functional class III&IV (a0R 4.67, 
      95% CI 1.82-12.00 p = < 0.01) and severe left atrial diameter enlargement (aOR 
      7.28, 95% CI 3.17-16.70 p = < 0.01). The critical point beyond which arrhythmias 
      develop was found to be left atrium diameter > 48 mm. CONCLUSION: We found a high 
      prevalence of arrhythmias among patients with RHD. The independent predictors of 
      arrhythmias were left atrium dilatation and NYHA functional class III-IV. We 
      recommend close monitoring for arrhythmias among RHD patients in sinus rhythm 
      with higher NYHA functional class and dilated left atrium.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Makatu, Clara Damascene
AU  - Makatu CD
AD  - School of Medicine, Department of Internal Medicine, Muhimbili University of 
      Health and Allied Sciences, Dar Es Salaam, P.O.BOX 65001, Tanzania. 
      claradamas.cd@gmail.com.
FAU - Mutagaywa, Reuben Kato
AU  - Mutagaywa RK
AD  - School of Medicine, Department of Internal Medicine, Muhimbili University of 
      Health and Allied Sciences, Dar Es Salaam, P.O.BOX 65001, Tanzania.
AD  - Department of Adult Cardiology, Jakaya Kikwete Cardiac Institute, Dar Es Salaam, 
      Tanzania.
FAU - Peter, Ponsian
AU  - Peter P
AD  - School of Medicine, Department of Pharmacology, Muhimbili University of Health 
      and AlliedSciences, Dar es salaam, Tanzania.
FAU - Barongo, Aileen
AU  - Barongo A
AD  - Department of Pediatrics and Child Health, Mwananyamala Regional Referral 
      Hospital, Dar es Salaam, Tanzania.
FAU - Kifai, Engerasiya
AU  - Kifai E
AD  - Department of Adult Cardiology, Jakaya Kikwete Cardiac Institute, Dar Es Salaam, 
      Tanzania.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230817
PL  - England
TA  - BMC Cardiovasc Disord
JT  - BMC cardiovascular disorders
JID - 100968539
SB  - IM
MH  - Female
MH  - Humans
MH  - Adult
MH  - *Rheumatic Heart Disease/diagnostic imaging/epidemiology
MH  - Prevalence
MH  - *Atrial Fibrillation
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Echocardiography
MH  - Heart Atria
PMC - PMC10433647
OTO - NOTNLM
OT  - Arrhythmias
OT  - Electrocardiography
OT  - Heart failure
OT  - Left atrium
OT  - Mitral stenosis
OT  - Rheumatic heart disease
COIS- The authors declare no competing interests.
EDAT- 2023/08/18 00:42
MHDA- 2023/08/21 06:42
PMCR- 2023/08/17
CRDT- 2023/08/17 23:38
PHST- 2022/09/17 00:00 [received]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/08/18 00:42 [pubmed]
PHST- 2023/08/17 23:38 [entrez]
PHST- 2023/08/17 00:00 [pmc-release]
AID - 10.1186/s12872-023-03427-0 [pii]
AID - 3427 [pii]
AID - 10.1186/s12872-023-03427-0 [doi]
PST - epublish
SO  - BMC Cardiovasc Disord. 2023 Aug 17;23(1):403. doi: 10.1186/s12872-023-03427-0.