PMID- 37592210
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20231121
IS  - 1471-244X (Electronic)
IS  - 1471-244X (Linking)
VI  - 23
IP  - 1
DP  - 2023 Aug 17
TI  - The effects of environmental factors associated with childhood urbanicity on 
      brain structure and cognition.
PG  - 598
LID - 10.1186/s12888-023-05066-3 [doi]
LID - 598
AB  - Urbanization is a trend lasting for more than one century worldwide. Four hundred 
      ninety male and female adult Chinese Han participants with different urban and 
      rural childhoods were included in this study. Early-life urban environment was 
      found benefit for total grey matter volume (GMV), dorsolateral prefrontal cortex 
      (DLPFC) GMV, temporal pole (TP) GMV and cognition function, and negatively 
      correlated with medial prefrontal cortex (MPFC) GMV. Regression analysis showed 
      that maternal education was a protective factor for total and DLPFC GMVs, while 
      having siblings was better for MPFC GMV. Total, DLPFC and TP GMVs acts mediation 
      effects between childhood urbanicity and different cognitive domains. These 
      findings may suggest some pros and cons on brain structure associated with 
      childhood urbanicity and related environmental factors.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Zhang, Xiao
AU  - Zhang X
AD  - Institute of Mental Health, National Clinical Research Center for Mental 
      Disorders, Peking University Sixth Hospital, 51 Huayuanbei Road, Haidian 
      District, Beijing, 100191, China. zhangx@bjmu.edu.cn.
AD  - NHC Key Laboratory of Mental Health (Peking University), 51 Huayuanbei Road, 
      Haidian District, Beijing, 100191, China. zhangx@bjmu.edu.cn.
FAU - Yan, Hao
AU  - Yan H
AD  - Institute of Mental Health, National Clinical Research Center for Mental 
      Disorders, Peking University Sixth Hospital, 51 Huayuanbei Road, Haidian 
      District, Beijing, 100191, China.
AD  - NHC Key Laboratory of Mental Health (Peking University), 51 Huayuanbei Road, 
      Haidian District, Beijing, 100191, China.
FAU - Yu, Hao
AU  - Yu H
AD  - Department of Psychiatry, Jining Medical University, Jining, Shandong, China.
FAU - Zhang, Yuyanan
AU  - Zhang Y
AD  - Institute of Mental Health, National Clinical Research Center for Mental 
      Disorders, Peking University Sixth Hospital, 51 Huayuanbei Road, Haidian 
      District, Beijing, 100191, China.
AD  - NHC Key Laboratory of Mental Health (Peking University), 51 Huayuanbei Road, 
      Haidian District, Beijing, 100191, China.
FAU - Tan, Hao Yang
AU  - Tan HY
AD  - Lieber Institute for Brain Development, Baltimore, MD, 21205, US.
AD  - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School 
      of Medicine, Baltimore, MD, 21205, US.
FAU - Zhang, Dai
AU  - Zhang D
AD  - Institute of Mental Health, National Clinical Research Center for Mental 
      Disorders, Peking University Sixth Hospital, 51 Huayuanbei Road, Haidian 
      District, Beijing, 100191, China.
AD  - NHC Key Laboratory of Mental Health (Peking University), 51 Huayuanbei Road, 
      Haidian District, Beijing, 100191, China.
AD  - PKU-IDG/McGovern Institute for Brain Research of Peking University, &Chinese 
      Institute for Brain Research, 51 Huayuanbei Road, Haidian District, Beijing, 
      100191, China.
FAU - Yue, Weihua
AU  - Yue W
AD  - Institute of Mental Health, National Clinical Research Center for Mental 
      Disorders, Peking University Sixth Hospital, 51 Huayuanbei Road, Haidian 
      District, Beijing, 100191, China. dryue@bjmu.edu.cn.
AD  - NHC Key Laboratory of Mental Health (Peking University), 51 Huayuanbei Road, 
      Haidian District, Beijing, 100191, China. dryue@bjmu.edu.cn.
AD  - PKU-IDG/McGovern Institute for Brain Research of Peking University, &Chinese 
      Institute for Brain Research, 51 Huayuanbei Road, Haidian District, Beijing, 
      100191, China. dryue@bjmu.edu.cn.
AD  - Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder, Chinese 
      Academy of Medical Sciences, 51 Huayuanbei Road, Haidian District, Beijing, 
      100191, China. dryue@bjmu.edu.cn.
LA  - eng
GR  - R01 MH101053/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20230817
PL  - England
TA  - BMC Psychiatry
JT  - BMC psychiatry
JID - 100968559
SB  - IM
MH  - Child
MH  - Adult
MH  - Female
MH  - Male
MH  - Humans
MH  - *Brain/diagnostic imaging
MH  - *Cognition
MH  - Gray Matter
MH  - Prefrontal Cortex
MH  - Cerebral Cortex
PMC - PMC10433654
OTO - NOTNLM
OT  - Childhood environment
OT  - Cognition
OT  - Grey matter volume
OT  - Having siblings
OT  - Maternal education
OT  - Urbanicity
COIS- The authors declare no competing interests.
EDAT- 2023/08/18 00:42
MHDA- 2023/08/21 06:42
PMCR- 2023/08/17
CRDT- 2023/08/17 23:38
PHST- 2023/02/06 00:00 [received]
PHST- 2023/07/30 00:00 [accepted]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/08/18 00:42 [pubmed]
PHST- 2023/08/17 23:38 [entrez]
PHST- 2023/08/17 00:00 [pmc-release]
AID - 10.1186/s12888-023-05066-3 [pii]
AID - 5066 [pii]
AID - 10.1186/s12888-023-05066-3 [doi]
PST - epublish
SO  - BMC Psychiatry. 2023 Aug 17;23(1):598. doi: 10.1186/s12888-023-05066-3.