PMID- 37592324
OWN - NLM
STAT- MEDLINE
DCOM- 20231107
LR  - 20240207
IS  - 1439-0507 (Electronic)
IS  - 0933-7407 (Print)
IS  - 0933-7407 (Linking)
VI  - 66
IP  - 12
DP  - 2023 Dec
TI  - Association of Kallikrein Related Peptidase 3 (KLK3) gene with dermatophytosis in 
      the UK biobank cohort.
PG  - 1050-1055
LID - 10.1111/myc.13649 [doi]
AB  - BACKGROUND: In a previous genome wide association study (GWAS) of UK Biobank 
      (UKB) data, we identified one susceptibility locus, tubulointerstitial nephritis 
      antigen (TINAG), with genome wide significance for dermatophytosis. We used 
      genotype calls from file UKB22418. These data are derived directly from 
      Affymetrix DNA microarrays but are missing many genotype calls. Using 
      computationally efficient approaches, UKB has entered imputed genotypes into a 
      second dataset, UKB22828, increasing the number of testable variants by over 
      100-fold to 96 million variants. METHODS: In the current study, we used UKB 
      imputed genotypes in UKB22828 to identify dermatophytosis susceptibility loci. To 
      identify cases of dermatophytosis, we used ICD10 code B35, which covers tinea 
      barbae, tinea capitis, tinea unguium, tinea manuum, tinea pedis, tinea corporis, 
      tinea imbricata, tinea cruris, other dermatophytoses and dermatophytosis, 
      unspecified. We used PLINK, a whole-genome association analysis toolset, to 
      analyse the UKB22828 chromosome files. RESULTS: GWAS summary (Manhattan) plot of 
      the meta-analysis association statistics highlighted two susceptibility loci, 
      TINAG and Kallikrein Related Peptidase 3 (KLK3), with genome wide significance 
      for dermatophytosis. KLK3, also known as prostate specific antigen (PSA), belongs 
      to a subclass of serine proteases with a variety of physiological functions. 
      CONCLUSION: KLK3 may be a dermatophytosis susceptibility gene. KLK3 could affect 
      risk of dermatophytosis, since kallikreins are necessary for normal homeostasis 
      of the skin.
CI  - (c) 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.
FAU - Lehrer, Steven
AU  - Lehrer S
AD  - Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New 
      York City, New York, USA.
FAU - Rheinstein, Peter H
AU  - Rheinstein PH
AD  - Severn Health Solutions, Severna Park, Maryland, USA.
LA  - eng
GR  - S10 OD018522/OD/NIH HHS/United States
GR  - S10 OD026880/OD/NIH HHS/United States
PT  - Journal Article
PT  - Meta-Analysis
DEP - 20230817
PL  - Germany
TA  - Mycoses
JT  - Mycoses
JID - 8805008
RN  - EC 3.4.21.- (Kallikreins)
RN  - EC 3.4.21.77 (Prostate-Specific Antigen)
RN  - EC 3.4.21.- (KLK3 protein, human)
SB  - IM
MH  - Humans
MH  - Male
MH  - Biological Specimen Banks
MH  - Genome-Wide Association Study
MH  - Kallikreins
MH  - *Prostate-Specific Antigen
MH  - *Tinea
MH  - United Kingdom/epidemiology
PMC - PMC10840734
MID - NIHMS1926172
OTO - NOTNLM
OT  - GWAS
OT  - dermatophytosis
OT  - genes
OT  - mycoses
OT  - polygenic
COIS- CONFLICT OF INTEREST STATEMENT The authors have no conflict of interest to 
      declare.
EDAT- 2023/08/18 00:42
MHDA- 2023/11/03 06:44
PMCR- 2024/02/05
CRDT- 2023/08/17 23:46
PHST- 2023/07/27 00:00 [revised]
PHST- 2023/04/26 00:00 [received]
PHST- 2023/08/04 00:00 [accepted]
PHST- 2023/11/03 06:44 [medline]
PHST- 2023/08/18 00:42 [pubmed]
PHST- 2023/08/17 23:46 [entrez]
PHST- 2024/02/05 00:00 [pmc-release]
AID - 10.1111/myc.13649 [doi]
PST - ppublish
SO  - Mycoses. 2023 Dec;66(12):1050-1055. doi: 10.1111/myc.13649. Epub 2023 Aug 17.