PMID- 37593614
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 2405-8440 (Print)
IS  - 2405-8440 (Electronic)
IS  - 2405-8440 (Linking)
VI  - 9
IP  - 8
DP  - 2023 Aug
TI  - Vitamin D alleviates hypothyroidism associated liver dysfunction: Histological 
      and biochemical evidence.
PG  - e18860
LID - 10.1016/j.heliyon.2023.e18860 [doi]
LID - e18860
AB  - There is a complex correlation between thyroid hormones (THs) and liver function. 
      Hypothyroidism as a failure of the thyroid gland to produce adequate thyroid 
      hormones to fulfill the metabolic requirements of the body, may perturb liver 
      structure and function. Emerging evidence suggests the protective effects of 
      vitamin D against liver damage. Herein, this study aimed to investigate the role 
      of vitamin D in hypothyroidism-associated liver injury. Forty male Wistar rats 
      were classified into 4 groups: control, hypothyroid (Hypo) group received 0.05% 
      PTU, Hypo- Vitamin D groups were given 100 and 500 IU/kg vitamin D orally via 
      gavage for 6 weeks. Serum level of liver function including alanine 
      aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline 
      phosphatase (ALP) were measured. Malondialdehyde (MDA) level, superoxide 
      dismutase (SOD) enzyme activity, and total thiol content were measured as 
      oxidative stress indicators in the liver tissue. Furthermore, to estimate liver 
      tissue fibrosis, Masson's trichrome staining was done. Our findings showed that 
      hypothyroidism-induced liver fibrosis was associated with increased levels of 
      ALT, AST and ALP. Though, vitamin D administration could significantly reduce the 
      ALT, AST and ALP in the serum and suppress the accumulation of collagen fibers. 
      Moreover, the activity of SOD and total thiol content was notably reduced, while 
      the MDA content was significantly increased in the PTU- induced hypothyroid rats 
      compared to the control group. Nonetheless, treatment with vitamin D improved 
      mentioned oxidative stress markers in the Hypo-vitamin D groups. In conclusion, 
      vitamin D due to its potential antioxidant and anti-fibrotic properties could be 
      effective in the decrease of hypothyroidism-associated liver injury.
CI  - (c) 2023 The Authors.
FAU - Rastegar-Moghaddam, Seyed Hamidreza
AU  - Rastegar-Moghaddam SH
AD  - Student Research Committee, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
AD  - Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University 
      of Medical Sciences, Mashhad, Iran.
FAU - Akbarian, Mahsan
AU  - Akbarian M
AD  - Applied Biomedical Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Rajabian, Arezoo
AU  - Rajabian A
AD  - Department of Internal Medicine, Faculty of Medicine, Imam Reza Hospital, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Alipour, Fatemeh
AU  - Alipour F
AD  - Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University 
      of Medical Sciences, Mashhad, Iran.
FAU - Ebrahimzadeh Bideskan, Alireza
AU  - Ebrahimzadeh Bideskan A
AD  - Department of Anatomy and Cell Biology, Faculty of Medicine, Mashhad University 
      of Medical Sciences, Mashhad, Iran.
AD  - Applied Biomedical Research Center, Mashhad University of Medical Sciences, 
      Mashhad, Iran.
FAU - Hosseini, Mahmoud
AU  - Hosseini M
AD  - Division of Neurocognitive Sciences, Psychiatry and Behavioral Sciences Research 
      Center, Mashhad University of Medical Sciences, Mashhad, Iran.
AD  - Department of Physiology, Faculty of Medicine, Mashhad University of Medical 
      Sciences, Mashhad, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230802
PL  - England
TA  - Heliyon
JT  - Heliyon
JID - 101672560
PMC - PMC10428045
OTO - NOTNLM
OT  - Fibrosis
OT  - Hypothyroidism
OT  - Liver
OT  - Oxidative stress
OT  - Vitamin D
COIS- The authors declare that they have no known competing financial interests or 
      personal relationships that could have appeared to influence the work reported in 
      this paper.
EDAT- 2023/08/18 06:42
MHDA- 2023/08/18 06:43
PMCR- 2023/08/02
CRDT- 2023/08/18 03:56
PHST- 2023/05/25 00:00 [received]
PHST- 2023/07/27 00:00 [revised]
PHST- 2023/07/31 00:00 [accepted]
PHST- 2023/08/18 06:43 [medline]
PHST- 2023/08/18 06:42 [pubmed]
PHST- 2023/08/18 03:56 [entrez]
PHST- 2023/08/02 00:00 [pmc-release]
AID - S2405-8440(23)06068-1 [pii]
AID - e18860 [pii]
AID - 10.1016/j.heliyon.2023.e18860 [doi]
PST - epublish
SO  - Heliyon. 2023 Aug 2;9(8):e18860. doi: 10.1016/j.heliyon.2023.e18860. eCollection 
      2023 Aug.