PMID- 37594560
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20230821
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 26
IP  - 8
DP  - 2023 Aug
TI  - Ethanol-Extracted Acorn Induces Anti-Inflammatory Effects in Human Keratinocyte 
      and Production of Hyaluronic Acid in Human Fibroblasts.
PG  - 595-604
LID - 10.1089/jmf.2022.K.0128 [doi]
AB  - Acorn (Quercus acutissima CARR.) has been used in traditional food and medicinal 
      ethnopharmacology in Asia, and it has shown multifarious functions such as 
      antidementia, antiobesity, and antiasthma functions. However, there is limited 
      scientific evidence about the efficacy of acorn for ameliorating skin problems. 
      Treatment with ethanol-extracted acorns (EeA's) ablated the expression of 
      inducible nitric oxide synthase (iNOS), cyclooxygenase 2 (COX2), monocyte 
      chemoattractant protein-1 (MCP-1), and interleukin (IL)-8 stimulated by tumor 
      necrosis factor (TNF)-alpha in human adult low calcium high temperature (HaCaT) cells 
      under sublethal dosages. In addition, treatment with EeA dose dependently 
      inhibited the ex vivo hyper keratin formation induced by TNF-alpha in HaCaT cells in 
      conjunction with the blockade of cytokeratin-1 (CK-1) and cytokeratin-5 (CK-5) 
      expression. Moreover, EeA treatment stimulated the expression of hyaluronic acid 
      (HA) expression in human fibroblasts in a dose-dependent manner. Linoleamide was 
      identified as the functional component of EeA using preparative high-performance 
      liquid chromatography and ultra high performance liquid chromatography-mass 
      spectrometry-mass spectrometry analysis, and the anti-inflammatory features and 
      enhanced HA expression were verified. Collectively, these results suggest the 
      efficacy of EeA supplementation in improving skin problems via anti-inflammation 
      and upregulating HA production.
FAU - Lee, Jungwhoi
AU  - Lee J
AUID- ORCID: 0000-0002-3453-0478
AD  - Department of Biotechnology, College of Applied Life Science, SARI, Jeju National 
      University, Jeju, Korea.
FAU - Jo, Sung-Eun
AU  - Jo SE
AD  - ChanChanHee, Inc., Jeju, Korea.
FAU - Han, Song-I
AU  - Han SI
AD  - Department of Biotechnology, College of Applied Life Science, SARI, Jeju National 
      University, Jeju, Korea.
FAU - Kim, Jae-Hoon
AU  - Kim JH
AD  - Department of Biotechnology, College of Applied Life Science, SARI, Jeju National 
      University, Jeju, Korea.
AD  - Subtropical/Tropical Organism Gene Bank, Jeju National University, Jeju, Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 9004-61-9 (Hyaluronic Acid)
RN  - 3K9958V90M (Ethanol)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Hyaluronic Acid
MH  - *Quercus
MH  - Keratinocytes
MH  - HaCaT Cells
MH  - Ethanol
OTO - NOTNLM
OT  - HA
OT  - acorn
OT  - atopic dermatitis
OT  - chemokine
OT  - keratinocyte
EDAT- 2023/08/18 12:42
MHDA- 2023/08/21 06:42
CRDT- 2023/08/18 11:07
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/08/18 12:42 [pubmed]
PHST- 2023/08/18 11:07 [entrez]
AID - 10.1089/jmf.2022.K.0128 [doi]
PST - ppublish
SO  - J Med Food. 2023 Aug;26(8):595-604. doi: 10.1089/jmf.2022.K.0128.