PMID- 37596396
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20231121
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Aug 18
TI  - Association between thyroid function and diabetes peripheral neuropathy in 
      euthyroid type 2 diabetes mellitus patients.
PG  - 13499
LID - 10.1038/s41598-023-40752-y [doi]
LID - 13499
AB  - Previous studies disclosed that a high thyroid stimulating hormone level is an 
      independent risk factor for diabetes peripheral neuropathy (DPN) in subclinical 
      hypothyroidism (SCH) patients with type 2 diabetes mellitus (T2DM). However, 
      whether thyroid metabolism has an effect on DPN in euthyroid T2DM patients 
      remains unknown. The aim of this study was to identify the association between 
      thyroid function and DPN in euthyroid T2DM patients. A set of 580 euthyroid T2DM 
      patients was enrolled in the current study and stratified into DPN and Non-DPN 
      groups. Mann-Whitney U test was performed to analyze the continuous variables of 
      biochemical and thyroid metabolism indicators, and the Chi-square test was used 
      to compare the categorical variables. Spearman correlation analysis was performed 
      to analyze the relationship between clinical indicators and free thyroxine (FT4). 
      By using the logistic regression analysis, the prevalence of DPN in different 
      thyroid function indicators were evaluated. T2DM patients with DPN had obviously 
      lower levels of aspartate aminotransferase (AST), alpha-hydroxybutyric 
      dehydrogenase (alpha-HBDH), superoxide dismutase (SOD), calcium (Ca), creatinine 
      (Cr), uric acid (UA), retinol binding protein (RBP), total protein (TP), albumin 
      (ALB), alanine aminotransferase (ALT) and FT4 than the T2DM patients without DPN 
      (P < 0.05). FT4 was associated with TP, prealbumin (PA), ALB, SOD, anion gap 
      (AG), Ca, chlorine (Cl), UA, RBP, apoprotein A (Apo A), apoprotein B (Apo B), 
      apoprotein E (Apo E), and total cholesterol (TC). According to the FT4 quartile, 
      participants were sequentially divided into four groups to compare the prevalence 
      of DPN between each group. The data suggested that the prevalence of DPN in these 
      four groups was 53.79%, 53.28%, 54.97%, 38.10%, respectively. Moreover, compared 
      with quartile 4, patients in quartile 1, 2, 3 all had a significantly higher risk 
      of DPN (P = 0.007, P = 0.011, P = 0.004). The level of FT4 was negatively 
      correlated with the prevalence of DPN in euthyroid T2DM patients.
CI  - (c) 2023. Springer Nature Limited.
FAU - He, Qingyuan
AU  - He Q
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Zeng, Zekun
AU  - Zeng Z
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Zhao, Man
AU  - Zhao M
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, 710061, Shaanxi, People's Republic of China.
AD  - Clinical Laboratory, Xi'an NO. 1 Hospital, Xi'an, 710002, Shaanxi, People's 
      Republic of China.
FAU - Ruan, Banjun
AU  - Ruan B
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, 710061, Shaanxi, People's Republic of China.
FAU - Chen, Pu
AU  - Chen P
AD  - Department of Endocrinology, The First Affiliated Hospital of Xi'an Jiaotong 
      University, Xi'an, 710061, Shaanxi, People's Republic of China. 
      chenpu124@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230818
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Albumins)
RN  - 0 (Calcium, Dietary)
RN  - 0 (Apoproteins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Thyroid Gland
MH  - Risk Factors
MH  - Albumins
MH  - Calcium, Dietary
MH  - Apoproteins
MH  - *Peripheral Nervous System Diseases
PMC - PMC10439138
COIS- The authors declare no competing interests.
EDAT- 2023/08/19 11:42
MHDA- 2023/08/21 06:42
PMCR- 2023/08/18
CRDT- 2023/08/18 23:27
PHST- 2022/10/21 00:00 [received]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/08/19 11:42 [pubmed]
PHST- 2023/08/18 23:27 [entrez]
PHST- 2023/08/18 00:00 [pmc-release]
AID - 10.1038/s41598-023-40752-y [pii]
AID - 40752 [pii]
AID - 10.1038/s41598-023-40752-y [doi]
PST - epublish
SO  - Sci Rep. 2023 Aug 18;13(1):13499. doi: 10.1038/s41598-023-40752-y.