PMID- 37596590
OWN - NLM
STAT- MEDLINE
DCOM- 20230821
LR  - 20231122
IS  - 1472-684X (Electronic)
IS  - 1472-684X (Linking)
VI  - 22
IP  - 1
DP  - 2023 Aug 19
TI  - Drug landscape in patients receiving general outpatient palliative care in 
      Germany: results from a retrospective analysis of 10,464 patients.
PG  - 118
LID - 10.1186/s12904-023-01231-3 [doi]
LID - 118
AB  - BACKGROUND: According to  section sign 27 and  section sign 87 1b of the German Social Code, Book V, 
      general outpatient palliative care (GOPC) aims to promote, maintain, and improve 
      the quality of life and self-determination of seriously ill people. It should 
      enable them to live in dignity until death in their preferred environment. 
      Instead of a curative approach GOPC treatment focuses on the multiprofessional 
      objective of alleviating symptoms and suffering on a case-by-case basis using 
      medication or other measures, as well as the management of an individual 
      treatment plan. The aim of this study was therefore to investigate to what extent 
      medication differs from 12 months prior GOPC treatment within 12 months following 
      GOPC treatment. METHODS: A retrospective database cross sectional study based on 
      the IQVIA Disease Analyzer (DA) was performed, including adult patients with 
      cancer diagnosis and at least one documentation of palliative support between 
      January 1st, 2018 and December 31st, 2021, in 805 general practices (GP). 
      RESULTS: The results of this study show, that in the context of general general 
      outpatient palliative care, there is a significant increase in the prescription 
      of opioids (18.3% vs. 37.7%), sedatives (7.8% vs. 16.2%) and antiemetics (5.3% 
      vs. 9.7%), as well as a significant reduction in other medications such as 
      statins (21.4% vs. 11.5%), proton pump inhibitors (PPI) (41.2% vs. 35.3%), or 
      antihypertensives (57.5% vs. 46.6%). CONCLUSIONS: Our results support the role of 
      GOPC as an important element in improving pharmacological symptom control and 
      deprescription to improve quality of life of patients at the end of their life.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Loosen, Sven H
AU  - Loosen SH
AD  - Department of Gastroenterology, Hepatology and Infectious Diseases, Medical 
      Faculty of Heinrich, University Hospital Duesseldorf, Heine University 
      Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany. 
      Sven.Loosen@med.uni-dusseldorf.de.
FAU - Schwartz, Jacqueline
AU  - Schwartz J
AD  - Interdisciplinary Center for Palliative Medicine, Medical Faculty of Heinrich, 
      University Hospital Duesseldorf, Heine University Duesseldorf, Moorenstrasse 5, 
      40225, Duesseldorf, Duesseldorf, Germany.
FAU - Grewe, Steven
AU  - Grewe S
AD  - Department of Gastroenterology, Hepatology and Infectious Diseases, Medical 
      Faculty of Heinrich, University Hospital Duesseldorf, Heine University 
      Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany.
FAU - Krieg, Sarah
AU  - Krieg S
AD  - Department of Gastroenterology, Hepatology and Infectious Diseases, Medical 
      Faculty of Heinrich, University Hospital Duesseldorf, Heine University 
      Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany.
FAU - Krieg, Andreas
AU  - Krieg A
AD  - Department of Surgery (A), Medical Faculty, University Hospital Duesseldorf, 
      Heinrich-Heine- University Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, 
      Germany.
FAU - Luedde, Tom
AU  - Luedde T
AD  - Department of Gastroenterology, Hepatology and Infectious Diseases, Medical 
      Faculty of Heinrich, University Hospital Duesseldorf, Heine University 
      Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany.
FAU - Batzler, Yann-Nicolas
AU  - Batzler YN
AD  - Interdisciplinary Center for Palliative Medicine, Medical Faculty of Heinrich, 
      University Hospital Duesseldorf, Heine University Duesseldorf, Moorenstrasse 5, 
      40225, Duesseldorf, Duesseldorf, Germany.
FAU - Kostev, Karel
AU  - Kostev K
AD  - Epidemiology, IQVIA, Frankfurt, Germany.
FAU - Neukirchen, Martin
AU  - Neukirchen M
AD  - Interdisciplinary Center for Palliative Medicine, Medical Faculty of Heinrich, 
      University Hospital Duesseldorf, Heine University Duesseldorf, Moorenstrasse 5, 
      40225, Duesseldorf, Duesseldorf, Germany.
AD  - Department of Anesthesiology, Medical Faculty of Heinrich, University Hospital 
      Duesseldorf, Heine University Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, 
      Germany.
FAU - Roderburg, Christoph
AU  - Roderburg C
AD  - Department of Gastroenterology, Hepatology and Infectious Diseases, Medical 
      Faculty of Heinrich, University Hospital Duesseldorf, Heine University 
      Duesseldorf, Moorenstrasse 5, 40225, Duesseldorf, Germany. 
      Christoph.roderburg@med.uni-duesseldorf.de.
LA  - eng
PT  - Journal Article
DEP - 20230819
PL  - England
TA  - BMC Palliat Care
JT  - BMC palliative care
JID - 101088685
RN  - 21068-51-9 (S 27)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Outpatients
MH  - *Palliative Care
MH  - Cross-Sectional Studies
MH  - Quality of Life
MH  - Retrospective Studies
MH  - Germany
PMC - PMC10439623
OTO - NOTNLM
OT  - Antiemetics
OT  - Deprescription
OT  - Medication
OT  - Opioids
OT  - Outpatient palliative care
OT  - Prescription
OT  - Sedatives
COIS- The authors declare no competing interests.
EDAT- 2023/08/19 11:42
MHDA- 2023/08/21 06:42
PMCR- 2023/08/19
CRDT- 2023/08/18 23:38
PHST- 2022/10/14 00:00 [received]
PHST- 2023/07/19 00:00 [accepted]
PHST- 2023/08/21 06:42 [medline]
PHST- 2023/08/19 11:42 [pubmed]
PHST- 2023/08/18 23:38 [entrez]
PHST- 2023/08/19 00:00 [pmc-release]
AID - 10.1186/s12904-023-01231-3 [pii]
AID - 1231 [pii]
AID - 10.1186/s12904-023-01231-3 [doi]
PST - epublish
SO  - BMC Palliat Care. 2023 Aug 19;22(1):118. doi: 10.1186/s12904-023-01231-3.