PMID- 37597292
OWN - NLM
STAT- MEDLINE
DCOM- 20230920
LR  - 20230920
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 263
DP  - 2023 Sep 15
TI  - Influence of bifenthrin exposure at different gestational stages on the neural 
      development.
PG  - 115365
LID - S0147-6513(23)00869-2 [pii]
LID - 10.1016/j.ecoenv.2023.115365 [doi]
AB  - Perinatal exposure to bifenthrin (BF) alters neurodevelopment. However, the most 
      susceptible time period to BF exposure and the possible mechanisms are not clear. 
      In the current study, pregnant female mice were treated with BF (0.5 mg/kg/d) at 
      three different stages [gestational day (GD) 0-5, 6-15 and 16-birth (B)] and 
      neurologic deficits were evaluated in offspring mice. BF exposure at GD 16-B 
      significantly altered the locomotor activity and caused learning and memory 
      impairments in 6-week-old offspring. Gestational BF exposure also caused neuronal 
      loss in the region of cornu ammonis of hippocampi of 6-week-old offspring. 
      Interestingly, neurobehavioral impairments and neuronal loss were not observed in 
      offspring at 10-week-old. BF exposure at GD 16-B also decreased protein levels of 
      VGluT1, NR1 and NR2A while increased the protein levels of NR2B and VGAT1, as 
      well as the gene levels of Il-1beta, Il-6 and Tnf-alpha in hippocampi of 6-week-old 
      offspring. Collectively, these data demonstrate that gestational exposure to a 
      low dose BF causes neurodevelopmental deficits that remit with the age and the 
      late-stage of pregnancy is the most susceptible time window to BF exposure. 
      Imbalance in excitatory/inhibitory neuronal transmission, altered expression 
      levels of NMDA receptors and increased neural inflammation may be associated with 
      BF prenatal exposure-triggered neurobehavioral impairments.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Xi, Chuchu
AU  - Xi C
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.
FAU - Shi, Xiaoqian
AU  - Shi X
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.
FAU - Wang, Yujing
AU  - Wang Y
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.
FAU - He, Jing
AU  - He J
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.
FAU - Jiang, Shan
AU  - Jiang S
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.
FAU - Niu, Bo
AU  - Niu B
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.
FAU - Chen, Ying
AU  - Chen Y
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.
FAU - Zhao, Fang
AU  - Zhao F
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      zhaofang0927@cpu.edu.cn.
FAU - Cao, Zhengyu
AU  - Cao Z
AD  - Department of TCM Pharmacology, School of Traditional Chinese Pharmacy, China 
      Pharmaceutical University, Nanjing, Jiangsu 211198, PR China. Electronic address: 
      zycao@cpu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230817
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 6B66JED0KN (bifenthrin)
SB  - IM
MH  - Female
MH  - Pregnancy
MH  - Animals
MH  - Mice
MH  - *Neurogenesis
MH  - Hippocampus
MH  - Inflammation
MH  - Learning
MH  - *Smegmamorpha
OTO - NOTNLM
OT  - Bifenthrin
OT  - Gestational exposure
OT  - Learning and memory
OT  - Locomotor activity
OT  - Neurodevelopmental deficits
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/08/20 00:41
MHDA- 2023/09/20 06:42
CRDT- 2023/08/19 18:01
PHST- 2023/05/04 00:00 [received]
PHST- 2023/07/28 00:00 [revised]
PHST- 2023/08/10 00:00 [accepted]
PHST- 2023/09/20 06:42 [medline]
PHST- 2023/08/20 00:41 [pubmed]
PHST- 2023/08/19 18:01 [entrez]
AID - S0147-6513(23)00869-2 [pii]
AID - 10.1016/j.ecoenv.2023.115365 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2023 Sep 15;263:115365. doi: 
      10.1016/j.ecoenv.2023.115365. Epub 2023 Aug 17.