PMID- 37597620 OWN - NLM STAT- MEDLINE DCOM- 20230911 LR - 20230911 IS - 1879-1298 (Electronic) IS - 0045-6535 (Linking) VI - 340 DP - 2023 Nov TI - Exposure to parabens and dysglycemia: Insights from a Chinese population. PG - 139868 LID - S0045-6535(23)02137-9 [pii] LID - 10.1016/j.chemosphere.2023.139868 [doi] AB - BACKGROUND: Parabens, a widely exposed environmental endocrine disruptor, were reported to disturb glucose metabolism through various pathways in animal models, but epidemiologic studies are limited. Therefore, this study aimed to investigate the plasma parabens level in rural populations and their effects of single and mixed paraben exposure on T2DM based on the Henan Rural Cohort. METHODS: A total of 1713 participants (880 T2DM and 833 controls) from the Henan Rural Cohort Study were included in this case-control study. Generalized linear regression models were performed to assess the single and joint effects of parabens on T2DM and glucose metabolism indicators. In addition, the dose-response relationship of plasma parabens with T2DM and glucose metabolism indicators were explored by the restricted cubic splines. Bayesian kernel machine regression (BKMR) and quantile g-computation models were utilized to assess overall associations of paraben mixtures with T2DM and glucose metabolism indicators. RESULTS: Sigmaparabens and methylparaben (MeP) exposure significantly increased the risk of T2DM (P < 0.01). However, ethylparaben (EtP) and butylparaben (BuP) were negatively related to T2DM (P < 0.01). Notably, non-linear relationships of EtP and BuP with T2DM were observed. When the level of EtP or BuP was above the inflection point observed in dose-response curve, the ORs and 95% CIs were 1.453 (1.252, 1.686) and 1.982 (1.444, 2.721), respectively. Moreover, the result of quantile g-computation also showed that exposure to high concentration of parabens mixture was positively related to the risk of T2DM. BKMR model indicated that parabens mixture was associated with glycometabolism following a U-shape and parabens mixture increased the risk of dysglycemia when all parabens concentrations were at or above their 55th percentile compared with the median. CONCLUSION: MeP or paraben mixture exposure levels showed a linear positive association with risk of T2DM. EtP and BuP were nonlinearly associated with glucose metabolism and moderate-high exposure contributed to T2DM. CI - Copyright (c) 2023 Elsevier Ltd. All rights reserved. FAU - Song, Yu AU - Song Y AD - Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wang, Mian AU - Wang M AD - Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Nie, Luting AU - Nie L AD - Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Liao, Wei AU - Liao W AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wei, Dandan AU - Wei D AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wang, Lulu AU - Wang L AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wang, Juan AU - Wang J AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Xu, Qingqing AU - Xu Q AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Huan, Changsheng AU - Huan C AD - Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Jia, Zexin AU - Jia Z AD - Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Mao, Zhenxing AU - Mao Z AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Wang, Chongjian AU - Wang C AD - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. FAU - Huo, Wenqian AU - Huo W AD - Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, PR China. Electronic address: huowenqian@zzu.edu.cn. LA - eng PT - Journal Article DEP - 20230817 PL - England TA - Chemosphere JT - Chemosphere JID - 0320657 RN - 3QPI1U3FV8 (butylparaben) RN - 14255EXE39 (ethyl-p-hydroxybenzoate) RN - IY9XDZ35W2 (Glucose) RN - A2I8C7HI9T (methylparaben) RN - 0 (Parabens) SB - IM MH - Humans MH - Bayes Theorem MH - Case-Control Studies MH - Cohort Studies MH - *Diabetes Mellitus, Type 2 MH - East Asian People MH - Glucose MH - *Parabens/toxicity OTO - NOTNLM OT - Mixed exposures OT - Parabens OT - Type 2 diabetes mellitus COIS- Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/08/20 00:41 MHDA- 2023/09/11 06:41 CRDT- 2023/08/19 19:24 PHST- 2023/04/25 00:00 [received] PHST- 2023/08/05 00:00 [revised] PHST- 2023/08/17 00:00 [accepted] PHST- 2023/09/11 06:41 [medline] PHST- 2023/08/20 00:41 [pubmed] PHST- 2023/08/19 19:24 [entrez] AID - S0045-6535(23)02137-9 [pii] AID - 10.1016/j.chemosphere.2023.139868 [doi] PST - ppublish SO - Chemosphere. 2023 Nov;340:139868. doi: 10.1016/j.chemosphere.2023.139868. Epub 2023 Aug 17.