PMID- 37597785
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230912
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 340
DP  - 2023 Nov 1
TI  - Functional connectivity mediating passive coping style and perceived stress in 
      predicting anxiety.
PG  - 828-834
LID - S0165-0327(23)01061-3 [pii]
LID - 10.1016/j.jad.2023.08.079 [doi]
AB  - BACKGROUND: Passive coping style (CS) and perceived stress play significant roles 
      as influencing factors in the development of anxiety. However, the underlying 
      neurobiological mechanism linking passive CS and perceived stress to anxiety 
      susceptibility remains elusive. Thus, we aimed to investigate the relationships 
      among passive CS, brain functional connectivity, perceived stress, and anxiety in 
      young adults. METHODS: Data from the longitudinal Gene-Brain-Behavior 
      Project(GBB) and Southwest University Longitudinal Imaging Multimodal 
      Project(SLIM) were used. We confirmed the relationship among anxiety, passive CS 
      and perceived stress. Then, we investigated the mediated functional connectivity 
      between passive CS and perceived stress, and used these functional connections to 
      predict present anxiety and follow-up anxiety one year later. RESULTS: Anxiety 
      scores were significantly positively correlated with passive CS and perceived 
      stress. At the brain network level, connections within the default mode network 
      (DMN) and between the somatomotor network (SMN) and subcortical network (SUN) 
      mediated the relationship between passive CS and perceived stress. Furthermore, 
      present anxiety and follow-up anxiety one year later could be predicted by these 
      mediated functional connections. Nodes with greater predictive contribution were 
      mainly located in the left anterior cingulate gyrus (ACC), left inferior parietal 
      gyrus (IPG), right superior frontal gyrus (SFG), and left middle frontal gyrus 
      (MFG), mainly distributed on the DMN. CONCLUSION: These findings demonstrated 
      that the mediated neurobiological mechanisms between passive CS and perceived 
      stress could be used to predict present and future anxiety, which enhance 
      understanding of the neurobiological basis of anxiety susceptibility in this 
      passive CS and perceived stress and may have implications for early preventing 
      and intervening mental disorders.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Feng, Qiuyang
AU  - Feng Q
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Center for Studies of Education and Psychology of Ethnic 
      Minorities In Southwest China, Southwest University (SWU), Chongqing 400715, 
      China.
FAU - Li, Yu
AU  - Li Y
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Faculty of Education, Southwest University (SWU), 
      Chongqing 400715, China.
FAU - Liu, Cheng
AU  - Liu C
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Faculty of Psychology, Southwest University (SWU), 
      Chongqing 400715, China.
FAU - Wang, Xueyang
AU  - Wang X
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Faculty of Psychology, Southwest University (SWU), 
      Chongqing 400715, China.
FAU - Tang, Shuang
AU  - Tang S
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Faculty of Psychology, Southwest University (SWU), 
      Chongqing 400715, China.
FAU - Tie, Bijie
AU  - Tie B
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Center for Studies of Education and Psychology of Ethnic 
      Minorities In Southwest China, Southwest University (SWU), Chongqing 400715, 
      China.
FAU - Li, Xianrui
AU  - Li X
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Faculty of Psychology, Southwest University (SWU), 
      Chongqing 400715, China.
FAU - Qiu, Jiang
AU  - Qiu J
AD  - Key Laboratory of Cognition and Personality (SWU), Ministry of Education, 
      Chongqing 400715, China; Faculty of Psychology, Southwest University (SWU), 
      Chongqing 400715, China; Southwest University Branch, Collaborative Innovation 
      Center of Assessment Toward Basic Education Quality at Beijing Normal University, 
      Chongqing 400715, China. Electronic address: qiuj318@swu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230818
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
SB  - IM
MH  - Young Adult
MH  - Humans
MH  - *Anxiety
MH  - *Anxiety Disorders
MH  - Adaptation, Psychological
MH  - Brain/diagnostic imaging
MH  - Stress, Psychological
OTO - NOTNLM
OT  - Anxiety
OT  - Functional connectivity
OT  - Neurobiological mechanism
OT  - Passive coping style
OT  - Perceived stress
COIS- Declaration of competing interest The authors declared no potential conflicts of 
      interest with respect to the research, authorship, and publication of this 
      article.
EDAT- 2023/08/20 00:41
MHDA- 2023/09/11 06:42
CRDT- 2023/08/19 19:27
PHST- 2023/04/25 00:00 [received]
PHST- 2023/08/02 00:00 [revised]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2023/09/11 06:42 [medline]
PHST- 2023/08/20 00:41 [pubmed]
PHST- 2023/08/19 19:27 [entrez]
AID - S0165-0327(23)01061-3 [pii]
AID - 10.1016/j.jad.2023.08.079 [doi]
PST - ppublish
SO  - J Affect Disord. 2023 Nov 1;340:828-834. doi: 10.1016/j.jad.2023.08.079. Epub 
      2023 Aug 18.