PMID- 37597816
OWN - NLM
STAT- MEDLINE
DCOM- 20230904
LR  - 20231002
IS  - 1095-953X (Electronic)
IS  - 0969-9961 (Linking)
VI  - 185
DP  - 2023 Sep
TI  - Dynamic functional connectivity reveals hyper-connected pattern and abnormal 
      variability in freezing of gait of Parkinson's disease.
PG  - 106265
LID - S0969-9961(23)00280-2 [pii]
LID - 10.1016/j.nbd.2023.106265 [doi]
AB  - BACKGROUND: Freezing of gait (FOG) is an intractable and paroxysmal gait disorder 
      that seriously affects the quality of life of Parkinson's disease (PD) patients. 
      Emerging studies have reported abnormal brain activity of distributed networks in 
      FOG patients, whereas ignoring the intrinsic dynamic fluctuations of functional 
      connectivity. The purpose of this study was to examine the dynamic functional 
      network connectivity (dFNC) of PD-FOG. METHODS: In total, 52 PD patients with FOG 
      (PD-FOG), 73 without FOG (PD-NFOG) and 38 healthy controls (HCs) received resting 
      state functional magnetic resonance imaging (rs-fMRI). Sliding window method, 
      k-means clustering and graph theory analysis were employed to retrieve dynamic 
      characteristics of PD-FOG. Partial correlation analysis was conducted to verify 
      whether the dFNC was related to freezing gait severity. RESULTS: Seven brain 
      networks were identified and configured into seven states. Compared to PD-NFOG, 
      significant spatial pattern was identified for state 2 in freezers, showing 
      increased functional coupling between default mode network (DMN) and basal 
      ganglia network (BG), as a concrete manifestation of increased precuneus-caudate 
      coupling. The mean dwell time and fractional window of state 2 had a positive 
      correlation with FOG severity. Furthermore, PD-FOG group exhibited lower variance 
      in nodal efficiency of independent components (IC) 7 (left precuneus). 
      CONCLUSIONS: Our study suggested that aberrant coupling of precuneus-caudate and 
      disrupted variability of precuneus efficiency might be associated to the neural 
      mechanisms of FOG.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Gan, Caiting
AU  - Gan C
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Ji, Min
AU  - Ji M
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Sun, Huimin
AU  - Sun H
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Cao, Xingyue
AU  - Cao X
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Shi, Jiaxin
AU  - Shi J
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Wang, Lina
AU  - Wang L
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Zhang, Heng
AU  - Zhang H
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China.
FAU - Yuan, Yongsheng
AU  - Yuan Y
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China. Electronic address: da_sheng@126.com.
FAU - Zhang, Kezhong
AU  - Zhang K
AD  - Department of Neurology, The First Affiliated Hospital of Nanjing Medical 
      University, Nanjing 210029, China. Electronic address: kezhong_zhang1969@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230818
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
SB  - IM
MH  - Humans
MH  - *Parkinson Disease/complications/diagnostic imaging
MH  - *Gait Disorders, Neurologic/diagnostic imaging/etiology
MH  - Quality of Life
MH  - Gait
MH  - Basal Ganglia
OTO - NOTNLM
OT  - Dynamic functional network connectivity
OT  - Dynamic graph theory property
OT  - Freezing of gait
OT  - Parkinson's disease
OT  - Resting-state functional connectivity
COIS- Declaration of Competing Interest None.
EDAT- 2023/08/20 00:41
MHDA- 2023/09/04 06:43
CRDT- 2023/08/19 19:28
PHST- 2023/06/12 00:00 [received]
PHST- 2023/08/11 00:00 [revised]
PHST- 2023/08/16 00:00 [accepted]
PHST- 2023/09/04 06:43 [medline]
PHST- 2023/08/20 00:41 [pubmed]
PHST- 2023/08/19 19:28 [entrez]
AID - S0969-9961(23)00280-2 [pii]
AID - 10.1016/j.nbd.2023.106265 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2023 Sep;185:106265. doi: 10.1016/j.nbd.2023.106265. Epub 2023 Aug 
      18.