PMID- 37598303
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231115
IS  - 1521-4141 (Electronic)
IS  - 0014-2980 (Linking)
VI  - 53
IP  - 11
DP  - 2023 Nov
TI  - Reprogramming dendritic cells through the immunological synapse: A two-way 
      street.
PG  - e2350393
LID - 10.1002/eji.202350393 [doi]
AB  - Dendritic cells (DCs) bridge innate and adaptive immunity. Their main function is 
      to present antigens to prime T cells and initiate and shape adaptive responses. 
      Antigen presentation takes place through intimate contacts between the two cells, 
      termed immune synapses (IS). During the formation of IS, information travels 
      towards the T-cell side to induce and tune its activation; but it also travels in 
      reverse via engagement of membrane receptors and within extracellular vesicles 
      transferred to the DC. Such reverse information transfer and its consequences on 
      DC fate have been largely neglected. Here, we review the events and effects of 
      IS-mediated antigen presentation on DCs. In addition, we discuss novel 
      technological advancements that enable monitoring DCs interactions with T 
      lymphocytes, the main effects of DCs undergoing productive IS (postsynaptic DCs, 
      or psDCs), and how reverse information transfer could be harnessed to modulate 
      immune responses for therapeutic intervention.
CI  - (c) 2023 The Authors. European Journal of Immunology published by Wiley-VCH GmbH.
FAU - Calzada-Fraile, Diego
AU  - Calzada-Fraile D
AUID- ORCID: 0000-0001-7259-0757
AD  - Intercellular Communication in the Inflammatory Response, Vascular 
      Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 
      Madrid, Spain.
FAU - Sanchez-Madrid, Francisco
AU  - Sanchez-Madrid F
AD  - Intercellular Communication in the Inflammatory Response, Vascular 
      Pathophysiology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), 
      Madrid, Spain.
AD  - Immunology Department, Instituto de Investigacion Sanitaria Hospital 
      Universitario La Princesa, Universidad Autonoma de Madrid, Madrid, Spain.
AD  - Centro de Investigacion Biomedica en Red de Enfermedades Cardiovasculares 
      (CIBERCV), Madrid, Spain.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20230907
PL  - Germany
TA  - Eur J Immunol
JT  - European journal of immunology
JID - 1273201
RN  - 0 (Antigens)
SB  - IM
MH  - *Immunological Synapses
MH  - *Dendritic Cells
MH  - T-Lymphocytes
MH  - Antigen Presentation
MH  - Antigens
OTO - NOTNLM
OT  - Antigen presentation
OT  - Dendritic cells
OT  - Immunological synapse
OT  - Intercellular communication
OT  - Postsynaptic dendritic cells
EDAT- 2023/08/20 06:41
MHDA- 2023/11/02 12:43
CRDT- 2023/08/20 05:27
PHST- 2023/08/16 00:00 [revised]
PHST- 2023/06/16 00:00 [received]
PHST- 2023/08/18 00:00 [accepted]
PHST- 2023/11/02 12:43 [medline]
PHST- 2023/08/20 06:41 [pubmed]
PHST- 2023/08/20 05:27 [entrez]
AID - 10.1002/eji.202350393 [doi]
PST - ppublish
SO  - Eur J Immunol. 2023 Nov;53(11):e2350393. doi: 10.1002/eji.202350393. Epub 2023 
      Sep 7.