PMID- 37599328
OWN - NLM
STAT- MEDLINE
DCOM- 20231005
LR  - 20240201
IS  - 1559-0100 (Electronic)
IS  - 1355-008X (Print)
IS  - 1355-008X (Linking)
VI  - 82
IP  - 2
DP  - 2023 Nov
TI  - Incidence and risk factors of asymptomatic bacteriuria in patients with type 2 
      diabetes mellitus: a meta-analysis.
PG  - 263-281
LID - 10.1007/s12020-023-03469-6 [doi]
AB  - BACKGROUND: The prevalence of type 2 diabetes mellitus (T2DM) is increasing each 
      year and has become one of the most prominent health concerns worldwide. Patients 
      with T2DM are prone to infectious diseases, and urinary tract infections are also 
      widespread. Despite a comprehensive understanding of urinary tract infection 
      (UTI), there is a lack of research regarding primary prevention strategies for 
      asymptomatic bacteriuria (ASB). OBJECTIVE: To clarify the incidence and risk 
      factors of asymptomatic urinary tract infection in patients with T2DM by 
      meta-analysis to provide evidence for preventing UTI. Help patients, their 
      families, and caregivers to identify the risk factors of patients in time and 
      intervene to reduce the incidence of ASB in patients with T2DM. Fill in the gaps 
      in existing research. STUDY DESIGN: Meta-analyses were conducted in line with 
      PRISMA guidelines. METHODS: Eleven databases were systematically searched for 
      articles about ASB in T2DM, and the retrieval time was selected from the 
      establishment of the database to February 5, 2023. Literature screening, quality 
      evaluation, and meta-analysis were independently performed by two researchers 
      according to the inclusion and exclusion criteria, and a meta-analysis was 
      performed using Stata 17.0. RESULTS: Fourteen articles were included, including 
      cohort and case-control studies. A meta-analysis of 4044 patients with T2DM was 
      included. The incidence of ASB in patients with T2DM was 23.7%(95% CI (0.183, 
      0.291); P < 0.001). After controlling for confounding variables, the following 
      risk factors were associated with ASB in patients with T2DM: age (WMD = 3.18, 95% 
      CI (1.91, 4.45), I(2) = 75.5%, P < 0.001), female sex (OR = 1.07, 95% CI(1.02, 
      1.12), I(2) = 79.3%, P = 0.002), duration of type 2 diabetes (WMD = 2.54, 95% CI 
      (1.53, 5.43), I(2) = 80.7%, P < 0.001), HbA1c (WMD = 0.63, 95% CI (0.43, 0.84), 
      I(2) = 62.6,%. P < 0.001), hypertension (OR = 1.59, 95% CI (1.24, 2.04), 
      I(2) = 0%, <0.001), hyperlipidemia (OR = 1.66, 95% CI (1.27, 2.18), I(2) = 0%, 
      P < 0.001), Neuropathy (OR = 1.81, 95% CI (1.38, 2.37), I(2) = 0%, P < 0.001), 
      proteinuria (OR = 3.00, 95% CI (1.82, 4.95), I(2) = 62.7%, P < 0.001). 
      CONCLUSION: The overall prevalence of ASB in T2DM is 23.7%. Age, female sex, 
      course of T2DM, HbA1C, hypertension, hyperlipidemia, neuropathy, and proteinuria 
      were identified as related risk factors for ASB in T2DM. These findings can 
      provide a robust theoretical basis for preventing and managing ASB in T2DM.
CI  - (c) 2023. The Author(s).
FAU - Dai, Mengqiao
AU  - Dai M
AD  - Shanghai University of Traditional Chinese Medicine, School of Nursing, Shanghai, 
      201203, China.
FAU - Hua, Shan
AU  - Hua S
AD  - Department of Urology, Shanghai General Hospital, Shanghai Jiao Tong University 
      School of Medicine, Shanghai, China.
FAU - Yang, Jiechao
AU  - Yang J
AD  - Shanghai University of Traditional Chinese Medicine, School of Nursing, Shanghai, 
      201203, China.
FAU - Geng, Dandan
AU  - Geng D
AD  - Shanghai University of Traditional Chinese Medicine, School of Nursing, Shanghai, 
      201203, China.
FAU - Li, Weina
AU  - Li W
AD  - Shanghai University of Traditional Chinese Medicine, School of Nursing, Shanghai, 
      201203, China.
FAU - Hu, Shuqin
AU  - Hu S
AD  - Shanghai University of Traditional Chinese Medicine, School of Nursing, Shanghai, 
      201203, China.
FAU - Chen, Hu
AU  - Chen H
AD  - Shanghai University of Traditional Chinese Medicine, School of Nursing, Shanghai, 
      201203, China.
FAU - Liao, Xiaoqin
AU  - Liao X
AD  - Shanghai University of Traditional Chinese Medicine, School of Nursing, Shanghai, 
      201203, China. pomeliao@aliyun.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20230821
PL  - United States
TA  - Endocrine
JT  - Endocrine
JID - 9434444
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Humans
MH  - Female
MH  - *Bacteriuria/epidemiology/etiology/diagnosis
MH  - *Diabetes Mellitus, Type 2/complications/epidemiology
MH  - Incidence
MH  - Glycated Hemoglobin
MH  - Risk Factors
MH  - *Urinary Tract Infections/etiology/complications
MH  - Proteinuria/complications
MH  - *Hyperlipidemias/complications
MH  - *Hypertension/complications
PMC - PMC10543815
OTO - NOTNLM
OT  - Asymptomatic bacteriuria
OT  - Incidence
OT  - Meta-analysis
OT  - Risk factor
OT  - Type 2 diabetes
COIS- The authors declare no competing interests.
EDAT- 2023/08/21 00:41
MHDA- 2023/10/05 06:43
PMCR- 2023/08/21
CRDT- 2023/08/20 23:07
PHST- 2023/03/25 00:00 [received]
PHST- 2023/06/28 00:00 [accepted]
PHST- 2023/10/05 06:43 [medline]
PHST- 2023/08/21 00:41 [pubmed]
PHST- 2023/08/20 23:07 [entrez]
PHST- 2023/08/21 00:00 [pmc-release]
AID - 10.1007/s12020-023-03469-6 [pii]
AID - 3469 [pii]
AID - 10.1007/s12020-023-03469-6 [doi]
PST - ppublish
SO  - Endocrine. 2023 Nov;82(2):263-281. doi: 10.1007/s12020-023-03469-6. Epub 2023 Aug 
      21.