PMID- 37599700
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 10
DP  - 2023
TI  - The effects of rutin supplement on blood pressure markers, some serum antioxidant 
      enzymes, and quality of life in patients with type 2 diabetes mellitus compared 
      with placebo.
PG  - 1214420
LID - 10.3389/fnut.2023.1214420 [doi]
LID - 1214420
AB  - BACKGROUND: This trial aimed to investigate the effects of rutin supplement in 
      type 2 diabetes mellitus (T2DM) patients. METHODS: In this trial with a 
      double-blind and controlled design, fifty patients were randomly divided into 
      intervention (n = 25) and control groups (n = 25) and were treated with 1 g of 
      rutin or placebo for three months, respectively. At the baseline and end of the 
      intervention, mean arterial pressure (MAP), heart rate (HR), pulse pressure (PP), 
      systolic and diastolic blood pressure (SBP and DBP), serum levels of antioxidant 
      enzymes, such as catalase (CAT), glutathione peroxidase (GPx), and superoxide 
      dismutase (SOD) and quality of life (QOL) parameters, were evaluated. RESULTS: 
      Rutin consumption caused a significant reduction in SBP, DBP, PP, MAP, and HR, 
      with a significant increase in SOD, CAT, and GPx and some QOL parameters 
      (emotional limitations, energy and freshness, mental health, social performance, 
      and general health) compared with baseline (p for all <0.05). Also, the mean 
      changes of emotional limitations, energy and freshness, mental health, and 
      general health (unadjusted p for all <0.05) and GPX and SOD (adjusted p for all 
      <0.05) were significantly higher in the rutin group compared with the placebo 
      group. Although, in the supplement group compared with the placebo group, the 
      mean changes of SBP, DBP, MAP, PP, and HR were significantly lower (adjusted p 
      for all <0.05). CONCLUSION: Rutin consumption improved blood pressure, the levels 
      of antioxidant enzymes, and QOL in patients with T2DM.
CI  - Copyright (c) 2023 Bazyar, Zare Javid, Ahangarpour, Zaman, Hosseini, Zohoori, 
      Aghamohammadi, Yazdanfar and Ghasemi Deh Cheshmeh.
FAU - Bazyar, Hadi
AU  - Bazyar H
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
AD  - Department of Public Health, Sirjan School of Medical Sciences, Sirjan, Iran.
AD  - Student Research Committee, Sirjan School of Medical Sciences, Sirjan, Iran.
FAU - Zare Javid, Ahmad
AU  - Zare Javid A
AD  - Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research 
      Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AD  - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
FAU - Ahangarpour, Akram
AU  - Ahangarpour A
AD  - Department of Physiology, Faculty of Medicine, Ahvaz Jundishapur University of 
      Medical Sciences, Ahvaz, Iran.
AD  - Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Zaman, Ferdows
AU  - Zaman F
AD  - Health Research Institute, Diabetes Research Center, Ahvaz Jundishapur University 
      of Medical Sciences, Ahvaz, Iran.
FAU - Hosseini, Seyed Ahmad
AU  - Hosseini SA
AD  - Nutrition and Metabolic Diseases Research Center, Clinical Sciences Research 
      Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
AD  - Department of Nutrition, School of Allied Medical Sciences, Ahvaz Jundishapur 
      University of Medical Sciences, Ahvaz, Iran.
FAU - Zohoori, Vida
AU  - Zohoori V
AD  - Teesside University, Middlesbrough, United Kingdom.
FAU - Aghamohammadi, Vahideh
AU  - Aghamohammadi V
AD  - Department of Nutrition, Khalkhal University of Medical Science, Khalkhal, Iran.
FAU - Yazdanfar, Shima
AU  - Yazdanfar S
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
FAU - Ghasemi Deh Cheshmeh, Mohammad
AU  - Ghasemi Deh Cheshmeh M
AD  - Student Research Committee, Ahvaz Jundishapur University of Medical Sciences, 
      Ahvaz, Iran.
LA  - eng
PT  - Journal Article
DEP - 20230803
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC10435270
OTO - NOTNLM
OT  - antioxidant enzymes
OT  - blood pressure
OT  - quality of life
OT  - rutin
OT  - type 2 diabetes mellitus
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/21 06:42
MHDA- 2023/08/21 06:43
PMCR- 2023/01/01
CRDT- 2023/08/21 04:35
PHST- 2023/05/22 00:00 [received]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/08/21 06:43 [medline]
PHST- 2023/08/21 06:42 [pubmed]
PHST- 2023/08/21 04:35 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2023.1214420 [doi]
PST - epublish
SO  - Front Nutr. 2023 Aug 3;10:1214420. doi: 10.3389/fnut.2023.1214420. eCollection 
      2023.