PMID- 37600302
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 2296-4185 (Print)
IS  - 2296-4185 (Electronic)
IS  - 2296-4185 (Linking)
VI  - 11
DP  - 2023
TI  - Preparation of hydroxyapatite nanofibers by using ionic liquids as template and 
      application in enhancing hydrogel performance.
PG  - 1247448
LID - 10.3389/fbioe.2023.1247448 [doi]
LID - 1247448
AB  - Introduction: Hydroxyapatite (HAP or HA) nanofibers are very attractive in the 
      field of biomedical engineering. However, templates used for preparing HAP 
      nanofibers are usually hydrophobic molecules, like fatty acids and/or 
      surfactants, which are difficult to remove and potentially toxic. Therefore, it 
      is important to develop a green approach to prepare HAP nanofibers. Methods: 
      Imidazolium-based ionic liquids (ILs) were used as templates to control the 
      crystallization of HAP. The obtained HAP nanofibers were composited into 
      polyvinyl alcohol-sodium alginate (PVA-Alg) hydrogel (HAP@H). The rheological 
      performance, stretching, and compression properties were tested. Scanning 
      electron microscope (SEM), high resolution transmission electron microscope 
      (HRTEM), X-ray diffraction (XRD), Fourier-transform infrared (FT-IR), and 
      differential scanning calorimetry (DSC) were adopted to characterize the 
      morphology, size, crystallographic orientations, and phase of HAP@H. Results: HAP 
      nanofibers with a length of  approximately 50 mum were harvested. The DSC results proved that 
      water loss temperature increased from 98 degrees C (for pure hydrogel) to 107 degrees C (for 
      HAP@H). Also, HAP@H hydrogel presented much better porous structure, tensile 
      performance, and compressive performance than that of pure hydrogel. Discussion: 
      The morphology, size, and growth direction of HAP could be modulated easily by 
      altering the alkyl chain length of ILs' cations. This is possibly due to 
      face-specific adsorption of imidazolium moieties on HAP nanocrystals. The 
      enhancing performance of HAP@H is probably due to the composited highly oriented 
      HAP nanofibers.
CI  - Copyright (c) 2023 Ren, Liang and Zhao.
FAU - Ren, Xiuli
AU  - Ren X
AD  - College of Pharmacy, Jinzhou Medical University, Jinzhou, China.
FAU - Liang, Zepeng
AU  - Liang Z
AD  - College of Pharmacy, Jinzhou Medical University, Jinzhou, China.
FAU - Zhao, Xingjun
AU  - Zhao X
AD  - College of Pharmacy, Jinzhou Medical University, Jinzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20230802
PL  - Switzerland
TA  - Front Bioeng Biotechnol
JT  - Frontiers in bioengineering and biotechnology
JID - 101632513
PMC - PMC10433687
OTO - NOTNLM
OT  - biomaterials
OT  - hydrogel
OT  - hydroxyapatite
OT  - ionic liquids
OT  - nanofibers
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/21 06:42
MHDA- 2023/08/21 06:43
PMCR- 2023/01/01
CRDT- 2023/08/21 04:43
PHST- 2023/06/26 00:00 [received]
PHST- 2023/07/19 00:00 [accepted]
PHST- 2023/08/21 06:43 [medline]
PHST- 2023/08/21 06:42 [pubmed]
PHST- 2023/08/21 04:43 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 1247448 [pii]
AID - 10.3389/fbioe.2023.1247448 [doi]
PST - epublish
SO  - Front Bioeng Biotechnol. 2023 Aug 2;11:1247448. doi: 10.3389/fbioe.2023.1247448. 
      eCollection 2023.