PMID- 37600552
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 1662-5161 (Print)
IS  - 1662-5161 (Electronic)
IS  - 1662-5161 (Linking)
VI  - 17
DP  - 2023
TI  - Similarities and differences between intermittent and continuous resting-state 
      fMRI.
PG  - 1238888
LID - 10.3389/fnhum.2023.1238888 [doi]
LID - 1238888
AB  - INTRODUCTION: Functional Magnetic Resonance Imaging (fMRI) block-design 
      experiments typically include active ON-blocks with presentation of cognitive 
      tasks which are contrasted with OFF- blocks with no tasks presented. OFF-blocks 
      in between ON-blocks can however, also be seen as a proxy for intermittent 
      periods of resting, inducing temporary resting-states. We still do not know if 
      brain activity during such intermittent periods reflects the same kind of 
      resting-state activity as that obtained during a continuous period, as is 
      typically the case in studies of the classic Default Mode Network (DMN). The 
      purpose of the current study was therefore to investigate both similarities and 
      differences in brain activity between intermittent and continuous resting 
      conditions. METHODS: There were 47 healthy participants in the 3T fMRI 
      experiment. Data for the intermittent resting-state condition were acquired from 
      resting-periods in between active task-processing periods in a standard ON-OFF 
      block design, with three different cognitive tasks presented during ON-blocks. 
      Data for the continuous resting-state condition were acquired during a 5 min 
      resting period after the task-design had been presented. RESULTS AND DISCUSSION: 
      The results showed that activity was overall similar in the two conditions, but 
      with some differences. These differences were within the DMN network, and for the 
      interaction of DMN with other brain networks. DMN maps showed weak overlap 
      between conditions in the medial prefrontal cortex (MPFC), and in particular for 
      the intermittent compared to the continuous resting-state condition. Moreover, 
      DMN showed strong connectivity with the salience network (SN) in the intermittent 
      resting-state condition, particularly in the anterior insula and the 
      supramarginal gyrus. The observed differences may reflect a "carry-over" effect 
      from task-processing to the next resting-state period, not present in the 
      continuous resting-state condition, causing interference from the ON-blocks. 
      Further research is needed to fully understand the extent of differences between 
      intermittent and continuous resting-state conditions.
CI  - Copyright (c) 2023 Beresniewicz, Riemer, Kazimierczak, Ersland, Craven, Hugdahl and 
      Gruner.
FAU - Beresniewicz, Justyna
AU  - Beresniewicz J
AD  - Department of Biological and Medical Psychology, University of Bergen, Bergen, 
      Norway.
FAU - Riemer, Frank
AU  - Riemer F
AD  - Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland 
      University Hospital, Bergen, Norway.
FAU - Kazimierczak, Katarzyna
AU  - Kazimierczak K
AD  - Department of Biological and Medical Psychology, University of Bergen, Bergen, 
      Norway.
AD  - Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland 
      University Hospital, Bergen, Norway.
FAU - Ersland, Lars
AU  - Ersland L
AD  - Department of Biological and Medical Psychology, University of Bergen, Bergen, 
      Norway.
AD  - Department of Clinical Engineering, Haukeland University Hospital, Bergen, 
      Norway.
FAU - Craven, Alexander R
AU  - Craven AR
AD  - Department of Biological and Medical Psychology, University of Bergen, Bergen, 
      Norway.
AD  - Department of Clinical Engineering, Haukeland University Hospital, Bergen, 
      Norway.
FAU - Hugdahl, Kenneth
AU  - Hugdahl K
AD  - Department of Biological and Medical Psychology, University of Bergen, Bergen, 
      Norway.
AD  - Division of Psychiatry, Haukeland University Hospital, Bergen, Norway.
FAU - Gruner, Renate
AU  - Gruner R
AD  - Mohn Medical Imaging and Visualization Centre, Department of Radiology, Haukeland 
      University Hospital, Bergen, Norway.
AD  - Department of Physics and Technology, University of Bergen, Bergen, Norway.
LA  - eng
PT  - Journal Article
DEP - 20230803
PL  - Switzerland
TA  - Front Hum Neurosci
JT  - Frontiers in human neuroscience
JID - 101477954
PMC - PMC10435290
OTO - NOTNLM
OT  - Default Mode Network (DMN)
OT  - block design
OT  - cognitive tasks
OT  - functional Magnetic Resonance Imaging (fMRI)
OT  - resting state
COIS- KH, LE, AC, and RG own shares in the company NordicNeuroLab Inc., which produced 
      the visual system used for presentation of the tasks during scanning. The 
      remaining authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/08/21 06:42
MHDA- 2023/08/21 06:43
PMCR- 2023/01/01
CRDT- 2023/08/21 04:47
PHST- 2023/06/12 00:00 [received]
PHST- 2023/07/12 00:00 [accepted]
PHST- 2023/08/21 06:43 [medline]
PHST- 2023/08/21 06:42 [pubmed]
PHST- 2023/08/21 04:47 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fnhum.2023.1238888 [doi]
PST - epublish
SO  - Front Hum Neurosci. 2023 Aug 3;17:1238888. doi: 10.3389/fnhum.2023.1238888. 
      eCollection 2023.