PMID- 37600570
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 1735-5303 (Print)
IS  - 2345-3656 (Electronic)
IS  - 1735-5303 (Linking)
VI  - 18
IP  - 2
DP  - 2023 Spring
TI  - MMP-9 and CCR7 as Possible Predictors of Lymph Node Metastasis in Laryngeal 
      Squamous Cell Carcinoma.
PG  - 156-164
LID - 10.30699/ijp.2023.563014.2986 [doi]
AB  - BACKGROUND & OBJECTIVE: The expression of matrix metalloproteinase-9 (MMP-9) and 
      chemokine receptor 7 (CCR7) is significantly associated with tumor invasion and 
      metastasis. Little is known regarding the potential of these markers in 
      predicting cancer metastasis in Laryngeal Squamous Cell Carcinoma (LSCC). 
      Therefore, this study aimed to dissect the potential of these markers in 
      predicting the lymph node metastasis in LSCC patients. METHODS: Sixty tissue 
      samples were obtained from the patients diagnosed pathologically with LSCC who 
      underwent partial or total laryngectomy. The expression of MMP-9 and CCR7 was 
      measured using the immunohistochemistry staining in the tissue samples of LSCC 
      patients. The ROC (receiver operating characteristic) curve was used to determine 
      the most significant cut-off points of expression according to the highest 
      sensitivity and specificity of both the markers to predict the lymph node 
      metastasis in LSCC. Then, the relationship between the clinicopathology features 
      and the expression of MMP-9 and CCR7 was evaluated. RESULTS: The expression of 
      both MMP-9 and CCR7 was significantly correlated with the lymph node metastasis 
      in LSCC (P<0.001). Furthermore, CCR7 expression exhibited the highest prediction 
      accuracy (AUC 95.7%) and sensitivity (100%) in predicting the lymph node 
      metastasis in LSCC compared to that of MMP-9 (AUC 92.9%, sensitivity 90%). We 
      also found that patients with larger tumor size (> 4 cm) had significantly higher 
      expression of MMP-9 and CCR7 (P<0.002 and P<0.001, respectively). The Elevated 
      expression level of CCR7 statistically correlated with higher MMP-9 expression 
      (P<0.001). CONCLUSION: MMP-9 and CCR7 might be beneficial as predictors of lymph 
      node metastasis in LSCC patients.
FAU - Rachmadi, Lisnawati
AU  - Rachmadi L
AD  - Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia 
      /Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
FAU - Laelasari, Ela
AU  - Laelasari E
AD  - Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia 
      /Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
FAU - Susanto, Yayi Dwina Billianti
AU  - Susanto YDB
AD  - Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia 
      /Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
FAU - Kusmardi, Kusmardi
AU  - Kusmardi K
AD  - Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia 
      /Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20230620
PL  - Iran
TA  - Iran J Pathol
JT  - Iranian journal of pathology
JID - 101515128
PMC - PMC10439748
OTO - NOTNLM
OT  - CCR7
OT  - Laryngeal Squamous Carcinoma
OT  - Lymph Node Metastasis
OT  - MMP-9
COIS- There are no conflict of interests declared by the authors.
EDAT- 2023/08/21 06:42
MHDA- 2023/08/21 06:43
PMCR- 2023/03/01
CRDT- 2023/08/21 04:47
PHST- 2022/10/10 00:00 [received]
PHST- 2022/01/31 00:00 [accepted]
PHST- 2023/08/21 06:43 [medline]
PHST- 2023/08/21 06:42 [pubmed]
PHST- 2023/08/21 04:47 [entrez]
PHST- 2023/03/01 00:00 [pmc-release]
AID - 10.30699/ijp.2023.563014.2986 [doi]
PST - ppublish
SO  - Iran J Pathol. 2023 Spring;18(2):156-164. doi: 10.30699/ijp.2023.563014.2986. 
      Epub 2023 Jun 20.