PMID- 37600621
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 2691-171X (Electronic)
IS  - 2691-171X (Linking)
VI  - 4
IP  - 3
DP  - 2023 Aug
TI  - Delayed Hypersensitivity Reaction to Infliximab Due to Mammalian Meat Allergy.
PG  - e322
LID - 10.1097/PG9.0000000000000322 [doi]
AB  - Mammalian meat allergy is a delayed immunoglobulin E (IgE) mediated 
      hypersensitivity reaction to galactose-alpha-1,3-galactose (alpha-gal). Alpha-gal 
      is an oligosaccharide present on glycoproteins and glycolipids of nonprimate 
      mammals as well as biologic agents prepared using mammalian cells including 
      infliximab. We describe a pediatric patient with Crohn's disease who developed 
      urticaria and pruritus roughly 6 hours after her very first infliximab infusion 
      that progressed to chronic urticaria following subsequent infliximab infusions. 
      She was diagnosed with mammalian meat allergy based on an elevated serum IgE 
      level directed against alpha-gal. Her symptoms resolved once infliximab infusions 
      were discontinued and did not recur after commencing therapy with adalimumab.
CI  - Copyright (c) 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on 
      behalf of the European Society for Pediatric Gastroenterology, Hepatology, and 
      Nutrition and the North American Society for Pediatric Gastroenterology, 
      Hepatology, and Nutrition.
FAU - Gonzalez Polanco, Esthermari
AU  - Gonzalez Polanco E
AD  - From the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, 
      Department of Pediatrics, University of Virginia, Charlottesville, USA.
FAU - Borowitz, Stephen
AU  - Borowitz S
AD  - From the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, 
      Department of Pediatrics, University of Virginia, Charlottesville, USA.
LA  - eng
PT  - Case Reports
DEP - 20230609
PL  - United States
TA  - JPGN Rep
JT  - JPGN reports
JID - 101773885
PMC - PMC10435023
OTO - NOTNLM
OT  - Infliximab
OT  - alpha-gal
OT  - inflammatory bowel disease
OT  - mammalian meat allergy
COIS- The authors report no conflicts of interest.
EDAT- 2023/08/21 06:42
MHDA- 2023/08/21 06:43
PMCR- 2023/06/09
CRDT- 2023/08/21 04:48
PHST- 2022/05/25 00:00 [received]
PHST- 2023/04/07 00:00 [accepted]
PHST- 2023/08/21 06:43 [medline]
PHST- 2023/08/21 06:42 [pubmed]
PHST- 2023/08/21 04:48 [entrez]
PHST- 2023/06/09 00:00 [pmc-release]
AID - 10.1097/PG9.0000000000000322 [doi]
PST - epublish
SO  - JPGN Rep. 2023 Jun 9;4(3):e322. doi: 10.1097/PG9.0000000000000322. eCollection 
      2023 Aug.