PMID- 37602101
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 7
DP  - 2023 Jul
TI  - Anesthesia Considerations for a Patient on Semaglutide and Delayed Gastric 
      Emptying.
PG  - e42153
LID - 10.7759/cureus.42153 [doi]
LID - e42153
AB  - Semaglutide is a class of long-acting glucagon-like peptide-1 receptor agonists 
      (GLP1-RA) used for the treatment of type 2 diabetes mellitus (T2DM) and 
      obesity. We present a 31-year-old female patient with a past medical history of 
      T2DM without complication and no long-term or current use of insulin, class 3 
      obesity, hypertension, hyperlipidemia, polycystic ovary syndrome (PCOS), and 
      anxiety, who underwent an esophagogastroduodenoscopy (EGD) in preparation for 
      bariatric surgery while taking semaglutide. Despite appropriately following the 
      preoperative fasting guidelines of the American Society of Anesthesiologists 
      (ASA), endoscopy revealed food residue in the gastric body, necessitating 
      abortion of the procedure to reduce the risk of intraoperative pulmonary 
      aspiration. Given the lack of preoperative fasting guidelines for patients on 
      semaglutide to date, and delayed gastric emptying being a known side effect among 
      patients taking semaglutide, anesthesiologists should be aware of alternative 
      methods to ensure no food is present in the stomach to mitigate the risk of 
      pulmonary aspiration during general anesthesia.
CI  - Copyright (c) 2023, Fujino et al.
FAU - Fujino, Erina
AU  - Fujino E
AD  - Anesthesiology, University of North Carolina at Chapel Hill School of Medicine, 
      Chapel Hill, USA.
FAU - Cobb, Kathryn W
AU  - Cobb KW
AD  - Anesthesiology, University of North Carolina at Chapel Hill School of Medicine, 
      Chapel Hill, USA.
FAU - Schoenherr, Jay
AU  - Schoenherr J
AD  - Anesthesiology, University of North Carolina at Chapel Hill School of Medicine, 
      Chapel Hill, USA.
FAU - Gouker, Lindsey
AU  - Gouker L
AD  - Anesthesiology, University of North Carolina at Chapel Hill School of Medicine, 
      Chapel Hill, USA.
FAU - Lund, Elisa
AU  - Lund E
AD  - Anesthesiology, University of North Carolina at Chapel Hill School of Medicine, 
      Chapel Hill, USA.
LA  - eng
PT  - Case Reports
DEP - 20230719
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10438952
OTO - NOTNLM
OT  - anesthesia
OT  - delayed gastric emptying
OT  - glp-1
OT  - glucagon-like peptide-1 receptor agonist
OT  - pulmonary aspiration
OT  - semaglutide
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/08/21 06:43
MHDA- 2023/08/21 06:44
PMCR- 2023/07/19
CRDT- 2023/08/21 05:09
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/08/21 06:44 [medline]
PHST- 2023/08/21 06:43 [pubmed]
PHST- 2023/08/21 05:09 [entrez]
PHST- 2023/07/19 00:00 [pmc-release]
AID - 10.7759/cureus.42153 [doi]
PST - epublish
SO  - Cureus. 2023 Jul 19;15(7):e42153. doi: 10.7759/cureus.42153. eCollection 2023 
      Jul.