PMID- 37603717
OWN - NLM
STAT- Publisher
LR  - 20230821
IS  - 1462-0332 (Electronic)
IS  - 1462-0324 (Linking)
DP  - 2023 Aug 21
TI  - Performance of GAP and ILD-GAP models in predicting lung transplant or death in 
      interstitial pneumonia with autoimmune features.
LID - kead428 [pii]
LID - 10.1093/rheumatology/kead428 [doi]
AB  - OBJECTIVES: To assess the ability of two risk prediction models in interstitial 
      lung disease (ILD) to predict death or lung transplantation in a cohort of 
      patients with interstitial pneumonia with autoimmune features (IPAF). METHODS: We 
      performed a retrospective cohort study of adults with IPAF at an academic medical 
      center. The primary outcome was a composite of lung transplantation or death. We 
      applied the patient data to the previously described GAP and ILD-GAP models to 
      determine the ability of these models to predict the composite outcome. Model 
      discrimination was assessed using the c-index, and model calibration was 
      determined by comparing the incidence ratios of observed versus expected deaths. 
      RESULTS: Ninety-four patients with IPAF were included. Mean (standard deviation) 
      age was 58 (13.5) years and the majority were female (62%). The majority met 
      serologic and morphologic criteria for IPAF (94% and 91%, respectively). The GAP 
      model had a c-index of 0.664 (95% confidence interval [CI] 0.547-0.781), while 
      the ILD-GAP model had a c-index of 0.569 (95% CI 0.440-0.697). In those with GAP 
      stage 1 or GAP stage 2 disease, calibration of the GAP model was satisfactory at 
      2 and 3 years for the cumulative end point of lung transplantation or death. 
      CONCLUSION: In patients with IPAF, the GAP model performed well as a predictor of 
      lung transplantation or death at 2 years and 3 years from ILD diagnosis in 
      patients with GAP stage 1 and GAP stage 2 disease.
CI  - (c) The Author(s) 2023. Published by Oxford University Press on behalf of the 
      British Society for Rheumatology. All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Allen, Michael R
AU  - Allen MR
AD  - Division of Rheumatology, Department of Medicine, Columbia University Irving 
      Medical Center, New York, NY, USA.
FAU - Alevizos, Michail K
AU  - Alevizos MK
AD  - Henry Dunant Medical Center, Athens, Greece.
FAU - Zhang, David
AU  - Zhang D
AD  - Division of Pulmonary, Allergy, and Critical Care Medicine, Department of 
      Medicine, Columbia University Irving Medical Center, New York, NY, USA.
FAU - Bernstein, Elana J
AU  - Bernstein EJ
AUID- ORCID: 0000-0001-5560-6390
AD  - Division of Rheumatology, Department of Medicine, Columbia University Irving 
      Medical Center, New York, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20230821
PL  - England
TA  - Rheumatology (Oxford)
JT  - Rheumatology (Oxford, England)
JID - 100883501
SB  - IM
OTO - NOTNLM
OT  - GAP
OT  - interstitial lung disease
OT  - interstitial pneumonia with autoimmune features
OT  - risk prediction model
EDAT- 2023/08/21 18:42
MHDA- 2023/08/21 18:42
CRDT- 2023/08/21 15:12
PHST- 2022/12/16 00:00 [received]
PHST- 2023/07/03 00:00 [revised]
PHST- 2023/08/02 00:00 [accepted]
PHST- 2023/08/21 18:42 [medline]
PHST- 2023/08/21 18:42 [pubmed]
PHST- 2023/08/21 15:12 [entrez]
AID - 7246760 [pii]
AID - 10.1093/rheumatology/kead428 [doi]
PST - aheadofprint
SO  - Rheumatology (Oxford). 2023 Aug 21:kead428. doi: 10.1093/rheumatology/kead428.