PMID- 37604668
OWN - NLM
STAT- MEDLINE
DCOM- 20230823
LR  - 20240417
IS  - 2051-817X (Electronic)
IS  - 2051-817X (Linking)
VI  - 11
IP  - 16
DP  - 2023 Aug
TI  - Differential effect of gold nanoparticles on cerebrovascular function and 
      biomechanical properties.
PG  - e15789
LID - 10.14814/phy2.15789 [doi]
LID - e15789
AB  - Human stroke serum (HSS) has been shown to impair cerebrovascular function, 
      likely by factors released into the circulation after ischemia. 20 nm gold 
      nanoparticles (GNPs) have demonstrated anti-inflammatory properties, with 
      evidence that they decrease pathologic markers of ischemic severity. Whether GNPs 
      affect cerebrovascular function, and potentially protect against the damaging 
      effects of HSS on the cerebral circulation remains unclear. HSS obtained 24 h 
      poststroke was perfused through the lumen of isolated and pressurized third-order 
      posterior cerebral arteries (PCAs) from male Wistar rats with and without GNPs 
      (~2 x 10(9) GNP/ml), or GNPs in vehicle, in an arteriograph chamber 
      (n = 8/group). All vessels were myogenically reactive >/=60 mmHg intravascular 
      pressure; however, vessels containing GNPs had significantly less myogenic tone. 
      GNPs increased vasoreactivity to small and intermediate conductance calcium 
      activated potassium channel activation via NS309; however, reduced 
      vasoconstriction to nitric oxide synthase inhibition. Hydraulic conductivity and 
      transvascular filtration, were decreased by GNPs, suggesting a protective effect 
      on the blood-brain barrier. The stress-strain curves of PCAs exposed to GNPs were 
      shifted leftward, indicating increased vessel stiffness. This study provides the 
      first evidence that GNPs affect the structure and function of the 
      cerebrovasculature, which may be important for their development and use in 
      biomedical applications.
CI  - (c) 2023 The Authors. Physiological Reports published by Wiley Periodicals LLC on 
      behalf of The Physiological Society and the American Physiological Society.
FAU - Hunt, Ryan D
AU  - Hunt RD
AUID- ORCID: 0009-0009-7899-5152
AD  - Department of Neurological Sciences, University of Vermont Larner College of 
      Medicine, Burlington, Vermont, USA.
FAU - Sedighi, Omid
AU  - Sedighi O
AUID- ORCID: 0000-0002-4766-7983
AD  - Department of Electrical and Biomedical Engineering, University of Vermont 
      College of Engineering and Mathematical Sciences, Burlington, Vermont, USA.
FAU - Clark, Wayne M
AU  - Clark WM
AD  - Oregon Stroke Center, Department of Neurology, Oregon Health, and Science 
      University, Portland, USA.
FAU - Doiron, Amber L
AU  - Doiron AL
AUID- ORCID: 0000-0002-6963-0989
AD  - Department of Electrical and Biomedical Engineering, University of Vermont 
      College of Engineering and Mathematical Sciences, Burlington, Vermont, USA.
FAU - Cipolla, Marilyn J
AU  - Cipolla MJ
AUID- ORCID: 0000-0002-9172-5941
AD  - Department of Neurological Sciences, University of Vermont Larner College of 
      Medicine, Burlington, Vermont, USA.
AD  - Department of Electrical and Biomedical Engineering, University of Vermont 
      College of Engineering and Mathematical Sciences, Burlington, Vermont, USA.
AD  - Department of Obstetrics, Gynecology and Reproductive Sciences, University of 
      Vermont Larner College of Medicine, Burlington, Vermont, USA.
AD  - Department of Pharmacology, University of Vermont Larner College of Medicine, 
      Burlington, Vermont, USA.
LA  - eng
GR  - R01 NS093289/NS/NINDS NIH HHS/United States
GR  - U54 GM115516/GM/NIGMS NIH HHS/United States
GR  - S10 OD025030/OD/NIH HHS/United States
GR  - S10 RR019246/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Physiol Rep
JT  - Physiological reports
JID - 101607800
RN  - 7440-57-5 (Gold)
SB  - IM
MH  - Rats
MH  - Humans
MH  - Animals
MH  - Male
MH  - Rats, Wistar
MH  - *Gold/pharmacology
MH  - *Metal Nanoparticles
MH  - Angiography
MH  - Blood-Brain Barrier
PMC - PMC10442527
OTO - NOTNLM
OT  - blood-brain barrier
OT  - cerebrovasculature
OT  - gold nanoparticles
OT  - ischemia
OT  - stroke
COIS- The authors declare no competing interests.
EDAT- 2023/08/22 00:41
MHDA- 2023/08/23 06:42
PMCR- 2023/08/21
CRDT- 2023/08/21 21:13
PHST- 2023/07/24 00:00 [revised]
PHST- 2023/03/29 00:00 [received]
PHST- 2023/07/24 00:00 [accepted]
PHST- 2023/08/23 06:42 [medline]
PHST- 2023/08/22 00:41 [pubmed]
PHST- 2023/08/21 21:13 [entrez]
PHST- 2023/08/21 00:00 [pmc-release]
AID - PHY215789 [pii]
AID - 10.14814/phy2.15789 [doi]
PST - ppublish
SO  - Physiol Rep. 2023 Aug;11(16):e15789. doi: 10.14814/phy2.15789.