PMID- 37605681
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230823
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 7
DP  - 2023 Jul
TI  - Low-Dose Oral Challenge Test in Pediatric Patients With Peanut Allergy: Tolerance 
      Assessment of a Trace 5 mg Peanut Test After Symptom Induction With a 500 mg 
      Test.
PG  - e42245
LID - 10.7759/cureus.42245 [doi]
LID - e42245
AB  - Introduction Peanut allergy (PA) represents a significant public health concern, 
      particularly prevalent in Western countries. Children at high risk for PA may 
      undergo a low-dose oral food challenge (OFC). However, if the result is positive, 
      complete elimination of peanuts from the diet is recommended, and further trace 
      OFC is typically not performed.  Material and methods This cross-sectional study 
      retrospectively examined the rate of positive peanut OFC with a total peanut load 
      of 5 mg in children who tested positive with a total peanut load of 500 mg. 
      Patient information was gathered from medical records. The primary endpoint was 
      the rate at which children who tested positive in the OFC with 500 mg of peanut 
      butter also tested positive with 5 mg of peanut butter equivalent.  Results Among 
      32 children who underwent an OFC with a total peanut load of 500 mg, two were 
      excluded for not meeting the criteria. Among the remaining 30 children, 14 
      (46.7%) had a positive 500 mg peanut OFC test, and three (10%) experienced an 
      anaphylactic reaction. Those who tested positive for the OFC had higher 
      peanut-specific and Ara h2-specific immunoglobulin E (IgE) antibodies. An OFC 
      with 5 mg of peanuts performed on 10 of the 14 patients who tested positive for 
      500 mg of peanuts showed no positive results. Conclusion The results of this 
      study suggest that children with severe PA who exhibit positive symptoms to a 
      total peanut load of 500 mg can tolerate a 5 mg dose of peanuts and should be 
      considered for an OFC.
CI  - Copyright (c) 2023, Horimukai et al.
FAU - Horimukai, Kenta
AU  - Horimukai K
AD  - Department of Pediatrics, Jikei University Katsushika Medical Center, Tokyo, JPN.
FAU - Kinoshita, Misako
AU  - Kinoshita M
AD  - Department of Pediatrics, Jikei University Katsushika Medical Center, Tokyo, JPN.
FAU - Takahata, Noriko
AU  - Takahata N
AD  - Department of Pediatrics, Jikei University Katsushika Medical Center, Tokyo, JPN.
LA  - eng
PT  - Journal Article
DEP - 20230721
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10440023
OTO - NOTNLM
OT  - child
OT  - oral challenge test
OT  - peanut allergy
OT  - peanut hypersensitivity
OT  - precautionary allergen labelling
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/08/22 06:42
MHDA- 2023/08/22 06:43
PMCR- 2023/07/21
CRDT- 2023/08/22 03:38
PHST- 2023/07/21 00:00 [accepted]
PHST- 2023/08/22 06:43 [medline]
PHST- 2023/08/22 06:42 [pubmed]
PHST- 2023/08/22 03:38 [entrez]
PHST- 2023/07/21 00:00 [pmc-release]
AID - 10.7759/cureus.42245 [doi]
PST - epublish
SO  - Cureus. 2023 Jul 21;15(7):e42245. doi: 10.7759/cureus.42245. eCollection 2023 
      Jul.