PMID- 37606448
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240210
IS  - 2036-749X (Print)
IS  - 2036-7503 (Electronic)
IS  - 2036-749X (Linking)
VI  - 15
IP  - 3
DP  - 2023 Aug 10
TI  - Inflammatory Biomarker Profiles in Very Preterm Infants within the Context of 
      Preeclampsia, Chorioamnionitis, and Clinically Diagnosed Postnatal Infection.
PG  - 483-493
LID - 10.3390/pediatric15030044 [doi]
AB  - Preterm delivery can be precipitated by preeclampsia or infection, and preterm 
      infants are at heightened risk of postnatal infection. Little is known about the 
      ontogeny of inflammatory biomarkers in extremely preterm infants. We hypothesized 
      that suspected prenatal infection (clinical chorioamnionitis or spontaneous 
      preterm labor) and clinically diagnosed postnatal infection would be associated 
      with unique biomarker signatures, and those patterns would be influenced by the 
      degree of prematurity. Venous blood was collected daily for the first week and 
      weekly for up to 14 additional weeks from 142 neonates born at 22-32 weeks 
      gestation. A custom array was utilized to measure monocyte chemoattractant 
      protein-1 (MCP-1) and interleukin-6 (IL-6). C-reactive protein (CRP) levels were 
      obtained from the electronic medical record. Independent of gestational age, 
      MCP-1 was significantly increased (p < 0.001) in association with maternal 
      preeclampsia, but MCP-1 was decreased (p < 0.01), and CRP was increased (p < 
      0.01) in the presence of chorioamnionitis with funisitis. IL-6 and CRP were both 
      increased in infants diagnosed with postnatal infection, with peak levels 
      observed on days 2 and 3, respectively. In conclusion, suspected prenatal and 
      postnatal infections and non-infectious complications of pregnancy are associated 
      with unique biomarker profiles, independent of gestational age, including over a 
      2-fold increase in MCP-1 among newborns of mothers with preeclampsia. Further, in 
      those clinically diagnosed with a postnatal infection in the absence of antenatal 
      infection concerns, IL-6 increases before CRP, emphasizing a potential role for 
      expanded biomarker screening if antibiotics are initially avoided in infants 
      delivered for maternal indications.
FAU - Ewald, Jordan T
AU  - Ewald JT
AD  - Roy J. Carver Department of Biomedical Engineering, University of Iowa, Iowa 
      City, IA 52242, USA.
FAU - Steinbrekera, Baiba
AU  - Steinbrekera B
AD  - Department of Pediatrics, University of South Dakota, Sioux Falls, SD 57069, USA.
FAU - Bermick, Jennifer R
AU  - Bermick JR
AD  - Stead Family Department of Pediatrics, Carver College of Medicine, University of 
      Iowa, Iowa City, IA 52242, USA.
FAU - Santillan, Donna A
AU  - Santillan DA
AUID- ORCID: 0000-0002-6180-9714
AD  - Department of Obstetrics and Gynecology, Carver College of Medicine, University 
      of Iowa, Iowa City, IA 52242, USA.
FAU - Colaizy, Tarah T
AU  - Colaizy TT
AD  - Stead Family Department of Pediatrics, Carver College of Medicine, University of 
      Iowa, Iowa City, IA 52242, USA.
FAU - Santillan, Mark K
AU  - Santillan MK
AD  - Department of Obstetrics and Gynecology, Carver College of Medicine, University 
      of Iowa, Iowa City, IA 52242, USA.
FAU - Roghair, Robert D
AU  - Roghair RD
AUID- ORCID: 0000-0002-0321-582X
AD  - Stead Family Department of Pediatrics, Carver College of Medicine, University of 
      Iowa, Iowa City, IA 52242, USA.
LA  - eng
GR  - R01 HD089940/HD/NICHD NIH HHS/United States
GR  - UL1TR002537/TR/NCATS NIH HHS/United States
PT  - Journal Article
DEP - 20230810
PL  - Switzerland
TA  - Pediatr Rep
JT  - Pediatric reports
JID - 101551542
PMC - PMC10443264
OTO - NOTNLM
OT  - adipokine
OT  - chemokine (C-C motif) ligand 2
OT  - interleukin-6
OT  - leptin
OT  - neonatal
OT  - preeclampsia
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2023/08/22 13:42
MHDA- 2023/08/22 13:43
PMCR- 2023/08/10
CRDT- 2023/08/22 09:15
PHST- 2023/05/12 00:00 [received]
PHST- 2023/07/24 00:00 [revised]
PHST- 2023/07/31 00:00 [accepted]
PHST- 2023/08/22 13:43 [medline]
PHST- 2023/08/22 13:42 [pubmed]
PHST- 2023/08/22 09:15 [entrez]
PHST- 2023/08/10 00:00 [pmc-release]
AID - pediatric15030044 [pii]
AID - pediatrrep-15-00044 [pii]
AID - 10.3390/pediatric15030044 [doi]
PST - epublish
SO  - Pediatr Rep. 2023 Aug 10;15(3):483-493. doi: 10.3390/pediatric15030044.