PMID- 37606729
OWN - NLM
STAT- MEDLINE
DCOM- 20231102
LR  - 20231221
IS  - 1434-4726 (Electronic)
IS  - 0937-4477 (Linking)
VI  - 280
IP  - 12
DP  - 2023 Dec
TI  - Effect of congenital inner ear malformations (IEMs) on electrically evoked 
      compound action potential (ECAP) responses in cochlear implant children.
PG  - 5193-5204
LID - 10.1007/s00405-023-08196-2 [doi]
AB  - PURPOSE: The study was designed to assess the electrically evoked compound action 
      potential (ECAP) responses in children with inner ear malformations compared to 
      children with normal inner ear anatomy. METHODS: The study included 235 
      prelingual deaf children who were implanted in cochlear implant unit in King 
      Fahad University hospital-Imam Abdulrahman Bin Faisel University. Subjects were 
      using either Cochlear Nucleus or Medel cochlear implant devices. We had 171 
      (64.5%) subjects with normal inner ear anatomy and 94 (35.5%) subjects with inner 
      ear malformations (IEMs) and they were classified into 6 groups according to 
      inner ear anatomy. Fourteen subjects (14.9%) subjects had enlarged vestibular 
      aqueduct (EVA), 30 (32%) subjects had Mondini deformity, 25 (26.6%) subjects had 
      incomplete partition type two (IPII), 9 (9.6%) subjects had incomplete partition 
      type one (IPI) and 16 (17%) subjects had hypoplastic cochlea type III or IV. 
      Intraoperative electrically evoked compound action potential (ECAP) responses 
      were analyzed and compared in all subjects. RESULTS AND CONCLUSIONS: Measurable 
      ECAP responses can be elicited in patients with IEMs in most of the channels. 
      Severe malformations can affect the prevalence of measuring ECAP and getting 
      identifiable waveform morphology. Additionally, increased thresholds and lower 
      slope of AGF was observed in IEMs specially in more severe malformations (e.g. 
      IPI). IPI patients with better word recognition scores tended to show more 
      identifiable ECAP measurements. This could suggest the presence of some 
      correlation between ECAP responses and patients' performance after cochlear 
      implantation.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, 
      part of Springer Nature.
FAU - Said, Nithreen M
AU  - Said NM
AUID- ORCID: 0000-0002-4371-8704
AD  - Audiovestibular Medicine Unit, Otorhinolaryngology Department, Faculty of 
      Medicine, Imam Abdulrahman Bin Faisal University, Dammam, Saudi Arabia. 
      nithreens@yahoo.com.
AD  - Audio-Vestibular Medicine Unit, Otorhinolaryngology Department, Faculty of 
      Medicine, Ain Shams University, Cairo, Egypt. nithreens@yahoo.com.
FAU - Telmesani, Lena S
AU  - Telmesani LS
AUID- ORCID: 0000-0003-0519-0344
AD  - Otorhinolaryngology Department, Faculty of Medicine, Imam Abdulrahman Bin Faisal 
      University, Dammam, Saudi Arabia.
FAU - Telmesani, Laila M
AU  - Telmesani LM
AUID- ORCID: 0000-0001-7237-4923
AD  - Otorhinolaryngology Department, Faculty of Medicine, Imam Abdulrahman Bin Faisal 
      University, Dammam, Saudi Arabia.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230822
PL  - Germany
TA  - Eur Arch Otorhinolaryngol
JT  - European archives of oto-rhino-laryngology : official journal of the European 
      Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the 
      German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
JID - 9002937
SB  - IM
MH  - Humans
MH  - Child
MH  - *Cochlear Implantation/methods
MH  - *Cochlear Implants
MH  - Action Potentials/physiology
MH  - *Hearing Loss, Sensorineural/surgery
MH  - *Ear, Inner/surgery
MH  - Evoked Potentials, Auditory/physiology
MH  - Electric Stimulation
OTO - NOTNLM
OT  - Auditory nerve responses
OT  - Cochlear implantation
OT  - Electric compound action potentials (ECAP)
OT  - Inner ear malformations
EDAT- 2023/08/22 13:42
MHDA- 2023/11/02 12:46
CRDT- 2023/08/22 11:13
PHST- 2023/06/17 00:00 [received]
PHST- 2023/08/14 00:00 [accepted]
PHST- 2023/11/02 12:46 [medline]
PHST- 2023/08/22 13:42 [pubmed]
PHST- 2023/08/22 11:13 [entrez]
AID - 10.1007/s00405-023-08196-2 [pii]
AID - 10.1007/s00405-023-08196-2 [doi]
PST - ppublish
SO  - Eur Arch Otorhinolaryngol. 2023 Dec;280(12):5193-5204. doi: 
      10.1007/s00405-023-08196-2. Epub 2023 Aug 22.