PMID- 37607433
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20240209
IS  - 1878-3279 (Electronic)
IS  - 0171-2985 (Linking)
VI  - 228
IP  - 6
DP  - 2023 Nov
TI  - Lycopene alleviates food allergy by modulating the PI3K/AKT pathway in 
      peanut-sensitized BALB/c mice.
PG  - 152731
LID - S0171-2985(23)04533-3 [pii]
LID - 10.1016/j.imbio.2023.152731 [doi]
AB  - Food allergies, which lead to life-threatening acute symptoms, are considered an 
      important public health problem. Therefore, it is essential to develop efficient 
      preventive and treatment measures. We developed a crude peanut protein extract 
      (PPE)-induced allergy mouse model to investigate the effects of lycopene on 
      peanut allergy. Mice were divided into four groups: 5 mg/kg lycopene, 20 mg/kg 
      lycopene, no treatment, and control groups. Serum inflammatory factors were 
      detected using enzyme-linked immunosorbent assay. In addition, pathology and 
      immunohistochemistry analyses were used to examine the small intestine of mice. 
      We found that lycopene decreased PPE-specific immunoglobulin E (IgE) and IL-13 
      levels in the serum, relieved small intestine inflammation, attenuated the 
      production of histamine and mouse mast cell protease-1, and downregulated PI3K 
      and AKT1 expression in the small intestine tissues of mice allergic to peanuts. 
      Our results suggest that lycopene can ameliorate allergy by attenuating the 
      PI3K/AKT pathway and the anaphylactic reactions mediated by PPE-specific IgE.
CI  - Copyright (c) 2023 Elsevier GmbH. All rights reserved.
FAU - He, Hongjuan
AU  - He H
AD  - Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Henan, 
      Zhengzhou 450046, China.
FAU - Ji, Xiaoyan
AU  - Ji X
AD  - Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Henan, 
      Zhengzhou 450046, China.
FAU - Cao, Lihua
AU  - Cao L
AD  - Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Henan, 
      Zhengzhou 450046, China.
FAU - Wang, Zhenzhen
AU  - Wang Z
AD  - Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Henan, 
      Zhengzhou 450046, China.
FAU - Wang, Xiaoyu
AU  - Wang X
AD  - Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Henan, 
      Zhengzhou 450046, China.
FAU - Li, Xiu-Min
AU  - Li XM
AD  - Department of Pathology, Microbiology & Immunology, New York Medical College, New 
      York, NY 10595, United States. Electronic address: XiuMin_Li@NYMC.EDU.
FAU - Miao, Mingsan
AU  - Miao M
AD  - Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Henan, 
      Zhengzhou 450046, China. Electronic address: miaomingsan@hactcm.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20230815
PL  - Netherlands
TA  - Immunobiology
JT  - Immunobiology
JID - 8002742
RN  - EC 2.7.1.- (Phosphatidylinositol 3-Kinases)
RN  - EC 2.7.11.1 (Proto-Oncogene Proteins c-akt)
RN  - SB0N2N0WV6 (Lycopene)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 0 (Allergens)
SB  - IM
MH  - Mice
MH  - Animals
MH  - Arachis/metabolism
MH  - Phosphatidylinositol 3-Kinases
MH  - Proto-Oncogene Proteins c-akt
MH  - Lycopene
MH  - Mice, Inbred BALB C
MH  - *Food Hypersensitivity/drug therapy
MH  - *Peanut Hypersensitivity/drug therapy/pathology
MH  - Immunoglobulin E
MH  - Allergens
OTO - NOTNLM
OT  - Food allergy
OT  - IgE
OT  - Lycopene
OT  - PI3K/AKT pathway
OT  - Peanut
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/08/23 00:41
MHDA- 2023/12/17 09:44
CRDT- 2023/08/22 18:02
PHST- 2023/05/09 00:00 [received]
PHST- 2023/07/23 00:00 [revised]
PHST- 2023/08/10 00:00 [accepted]
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/08/23 00:41 [pubmed]
PHST- 2023/08/22 18:02 [entrez]
AID - S0171-2985(23)04533-3 [pii]
AID - 10.1016/j.imbio.2023.152731 [doi]
PST - ppublish
SO  - Immunobiology. 2023 Nov;228(6):152731. doi: 10.1016/j.imbio.2023.152731. Epub 
      2023 Aug 15.