PMID- 37608849
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230824
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Examining the Links Between Physical Activity, Sitting Time, and Renal Function 
      in T2DM Patients.
PG  - 2469-2476
LID - 10.2147/DMSO.S408677 [doi]
AB  - BACKGROUND: Sitting time and physical activity are related to renal function 
      among type 2 diabetes mellitus (T2DM); however, the mechanism of how it 
      contributes to renal function is not well understood. The current study attempts 
      to explore the relationship between sitting time and renal function among T2DM 
      patients, with a particular focus on the mediating role of physical activity. 
      METHODS: This research uses the data of 1761 Chinese T2DM patients from Ningxia 
      Province. Sitting time and physical activity were obtained during a face-to-face 
      survey, and renal function was assessed by the estimated glomerular filtration 
      rate (eGFR). The bootstrap method is used to test the mediating effect. RESULTS: 
      The research found that sitting time was negatively associated with eGFR and 
      physical activity after controlling for covariates. Physical activity was 
      positively associated with eGFR. Physical activity has mediated the relationship 
      between sitting time and eGFR among T2DM patients (explaining 16.1% of the total 
      variance). CONCLUSION: The present findings suggest that sitting time negatively 
      affects eGFR among T2DM patients and provides new evidence that physical activity 
      could attenuate the association between sitting time and eGFR. Hence, 
      intervention strategies focusing on sitting time and physical activity should be 
      paid more attention in the future.
CI  - (c) 2023 Wang et al.
FAU - Wang, Xiaoyu
AU  - Wang X
AD  - School of Traditional Chinese Medicine, Ningxia Medical University, Yinchuan, 
      People's Republic of China.
FAU - Yan, Ning
AU  - Yan N
AUID- ORCID: 0000-0002-8190-1921
AD  - Heart Centre & Department of Cardiovascular Diseases, General Hospital of Ningxia 
      Medical University, Yinchuan, People's Republic of China.
FAU - Pan, Ruiping
AU  - Pan R
AD  - Department of Chinese Medicine, The Second People's Hospital of Shizuishan, 
      Shizuishan, People's Republic of China.
FAU - Dang, Yuqi
AU  - Dang Y
AD  - Department of Endocrinology, Yinchuan Hospital of Traditional Chinese Medicine, 
      Yinchuan, People's Republic of China.
FAU - Wang, Liqun
AU  - Wang L
AD  - Department of Epidemiology and Statistics, School of Public Health at Ningxia 
      Medical University, Yinchuan, People's Republic of China.
AD  - Key Laboratory of Environmental Factors and Chronic Disease Control, Ningxia 
      Medical University, Yinchuan, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20230816
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10440599
OTO - NOTNLM
OT  - T2DM patients
OT  - eGFR
OT  - mediating effect
OT  - physical activity
OT  - sitting time
COIS- All authors declare that there is no conflict of interest.
EDAT- 2023/08/23 06:42
MHDA- 2023/08/23 06:43
PMCR- 2023/08/16
CRDT- 2023/08/23 03:49
PHST- 2023/02/15 00:00 [received]
PHST- 2023/08/09 00:00 [accepted]
PHST- 2023/08/23 06:43 [medline]
PHST- 2023/08/23 06:42 [pubmed]
PHST- 2023/08/23 03:49 [entrez]
PHST- 2023/08/16 00:00 [pmc-release]
AID - 408677 [pii]
AID - 10.2147/DMSO.S408677 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Aug 16;16:2469-2476. doi: 10.2147/DMSO.S408677. 
      eCollection 2023.