PMID- 3760942
OWN - NLM
STAT- MEDLINE
DCOM- 19861112
LR  - 20191101
IS  - 0270-6474 (Print)
IS  - 1529-2401 (Electronic)
IS  - 0270-6474 (Linking)
VI  - 6
IP  - 10
DP  - 1986 Oct
TI  - Forward and backward classical conditioning of the flexion reflex in the spinal 
      cat.
PG  - 2921-5
AB  - Effects of forward and backward conditioned-unconditioned stimulus (CS-US) 
      intervals on classical conditioning of the flexion reflex were examined in a cat 
      spinal preparation. Interstimulus intervals (ISIs) ranging from +3.0 to -3.0 sec 
      were employed in 9 experimental groups and the results compared with those of an 
      explicitly unpaired control group. Forward conditioning produced an asymmetrical, 
      inverted U-shaped gradient relating magnitude of conditioning to ISI for both 
      acquisition and extinction. The optimum ISI was 1.0 sec. Backward ISIs also 
      produced excitatory conditioning, with optimal conditioning at -0.25 sec. Unlike 
      forward conditioning, backward conditioning produced little sign of retention 
      during extinction trials. The results, which parallel in several ways those of 
      ISI effects in studies of intact animals, support the hypothesis that backward 
      and forward conditioning may be fundamentally different phenomena, under the 
      control of different neural processes.
FAU - Durkovic, R G
AU  - Durkovic RG
FAU - Damianopoulos, E N
AU  - Damianopoulos EN
LA  - eng
PT  - Journal Article
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - J Neurosci
JT  - The Journal of neuroscience : the official journal of the Society for 
      Neuroscience
JID - 8102140
SB  - IM
MH  - Animals
MH  - Cats
MH  - Conditioning, Classical/*physiology
MH  - Decerebrate State/*physiopathology
MH  - Female
MH  - Male
MH  - Reflex/*physiology
PMC - PMC6568774
EDAT- 1986/10/01 00:00
MHDA- 1986/10/01 00:01
PMCR- 1987/04/01
CRDT- 1986/10/01 00:00
PHST- 1986/10/01 00:00 [pubmed]
PHST- 1986/10/01 00:01 [medline]
PHST- 1986/10/01 00:00 [entrez]
PHST- 1987/04/01 00:00 [pmc-release]
AID - 10.1523/JNEUROSCI.06-10-02921.1986 [doi]
PST - ppublish
SO  - J Neurosci. 1986 Oct;6(10):2921-5. doi: 10.1523/JNEUROSCI.06-10-02921.1986.