PMID- 37611100
OWN - NLM
STAT- MEDLINE
DCOM- 20230825
LR  - 20230921
IS  - 2375-2548 (Electronic)
IS  - 2375-2548 (Linking)
VI  - 9
IP  - 34
DP  - 2023 Aug 25
TI  - Spatially differential regulation of ATF2 phosphorylation contributes to warning 
      coloration of gregarious locusts.
PG  - eadi5168
LID - 10.1126/sciadv.adi5168 [doi]
LID - eadi5168
AB  - Warning coloration are common defense strategies used by animals to deter 
      predators. Pestilential gregarious locusts exhibit a notable black-brown pattern 
      as a form of warning coloration. However, the mechanisms regulating this 
      distinctive pattern remain largely unknown. Here, we revealed that the black and 
      brown integuments of locusts are governed by varying amounts of beta-carotene and 
      beta-carotene-binding protein (betaCBP) complexes. betaCBP expression is regulated by the 
      bZIP transcription factor activation transcription factor 2 (ATF2), which is 
      activated by protein kinase C alpha in response to crowding. Specifically, ATF2 
      is phosphorylated at Ser(327) and translocates to the nucleus, where it binds to 
      the betaCBP promoter and stimulates overexpression. Differential phosphorylation of 
      ATF2 leads to the divergent black and brown coloration in gregarious locusts. The 
      accumulation of red pigments vital for creating the brown sternum depends on betaCBP 
      overexpression. The spatial variation in ATF2 phosphorylation enables locusts to 
      rapidly adapt to changing environment for aposematism.
FAU - Kang, Xinle
AU  - Kang X
AUID- ORCID: 0000-0001-7071-9983
AD  - Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, 
      China.
FAU - Yang, Meiling
AU  - Yang M
AUID- ORCID: 0000-0002-6277-1842
AD  - College of Life Science, Capital Normal University, Beijing 100048, China.
FAU - Cui, Xiaoshuang
AU  - Cui X
AD  - State Key Laboratory of Integrated Management of Pest Insects and Rodents, 
      Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
FAU - Wang, Huimin
AU  - Wang H
AD  - College of Life Science, Capital Normal University, Beijing 100048, China.
FAU - Kang, Le
AU  - Kang L
AUID- ORCID: 0000-0003-4262-2329
AD  - Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, 
      China.
AD  - State Key Laboratory of Integrated Management of Pest Insects and Rodents, 
      Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.
LA  - eng
PT  - Journal Article
DEP - 20230823
PL  - United States
TA  - Sci Adv
JT  - Science advances
JID - 101653440
RN  - 01YAE03M7J (beta Carotene)
SB  - IM
MH  - Animals
MH  - Phosphorylation
MH  - beta Carotene
MH  - *Biological Mimicry
MH  - Cell Nucleus
MH  - *Grasshoppers
PMC - PMC10446495
EDAT- 2023/08/23 18:42
MHDA- 2023/08/25 06:42
PMCR- 2023/08/23
CRDT- 2023/08/23 14:03
PHST- 2023/08/25 06:42 [medline]
PHST- 2023/08/23 18:42 [pubmed]
PHST- 2023/08/23 14:03 [entrez]
PHST- 2023/08/23 00:00 [pmc-release]
AID - adi5168 [pii]
AID - 10.1126/sciadv.adi5168 [doi]
PST - ppublish
SO  - Sci Adv. 2023 Aug 25;9(34):eadi5168. doi: 10.1126/sciadv.adi5168. Epub 2023 Aug 
      23.