PMID- 37611889
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240221
IS  - 1638-6183 (Electronic)
IS  - 0300-9084 (Linking)
VI  - 218
DP  - 2024 Mar
TI  - Analysis of the function and therapeutic strategy of connexin 43 from its 
      subcellular localization.
PG  - 1-7
LID - S0300-9084(23)00202-X [pii]
LID - 10.1016/j.biochi.2023.08.011 [doi]
AB  - Connexins (Cxs) are a family of transmembrane proteins located in the plasma 
      membrane of human cells, among which connexin 43 (Cx43) is abundantly expressed 
      in various types of human cells. Cx43, encoded by the gap junction protein alpha 
      1 (GJA1) gene, assembles into a hexameric structure in the Golgi apparatus and 
      translocates to the plasma membrane to form hemichannels (Hcs), which pair with 
      those of the cells in contact with each other and form gap junction intercellular 
      communication (GJIC). The role of Cx43 as a connexin localized at the plasma 
      membrane to perform channel functions is well recognized in previous studies, but 
      recent studies have found that it can also be localized in the nucleus, 
      mitochondria, or present in extracellular vesicles (EVs) and tunneling nanotubes 
      (TNTs). Cx43 in the nucleus is involved in gene transcription regulation, 
      cytoskeleton formation, cell migration and adhesion. Cx43 in mitochondria is 
      involved in mitochondrial respiration-related functions, and Cx43 in 
      extracellular vesicles and tunneling nanotubes is involved in distant cellular 
      information exchange. It is because of the diverse distribution of subcellular 
      localization of Cx43 that it is possible to explore the corresponding functions 
      by analyzing its localization. In this review, we summarize the important roles 
      of Cx43 in disease development from the perspective of subcellular localization, 
      and provide new ideas for Cx43 as a therapeutic target and the search for related 
      pathological mechanisms.
CI  - Copyright (c) 2023 The Authors. Published by Elsevier B.V. All rights reserved.
FAU - Xiong, Xinhai
AU  - Xiong X
AD  - The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 
      410003, China.
FAU - Chen, Wenjie
AU  - Chen W
AD  - The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 
      410003, China.
FAU - Chen, Cheng
AU  - Chen C
AD  - The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 
      410003, China; 926 Hospital of the People's Liberation Army, Kaiyuan, Yunnan, 
      661600, China. Electronic address: 202120213677@hunnu.edu.cn.
FAU - Wu, Qi
AU  - Wu Q
AD  - The Second Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 
      410003, China.
FAU - He, Chaopeng
AU  - He C
AD  - The Second Xiangya Hospital, Changsha, Hunan, 410011, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20230822
PL  - France
TA  - Biochimie
JT  - Biochimie
JID - 1264604
RN  - 0 (Connexin 43)
RN  - 0 (Connexins)
SB  - IM
MH  - Humans
MH  - *Connexin 43/genetics/metabolism
MH  - *Connexins/genetics/metabolism
MH  - Gap Junctions/metabolism
MH  - Cell Membrane/metabolism
MH  - Gene Expression Regulation
MH  - Cell Communication
OTO - NOTNLM
OT  - Connexin 43
OT  - Extracellular vesicles
OT  - Gap junctions
OT  - Mitochondria
OT  - Nucleus
COIS- Declaration of competing interest The authors declare that there is no conflict 
      of interest.
EDAT- 2023/08/24 00:42
MHDA- 2024/02/21 11:16
CRDT- 2023/08/23 19:27
PHST- 2023/04/04 00:00 [received]
PHST- 2023/08/07 00:00 [revised]
PHST- 2023/08/18 00:00 [accepted]
PHST- 2024/02/21 11:16 [medline]
PHST- 2023/08/24 00:42 [pubmed]
PHST- 2023/08/23 19:27 [entrez]
AID - S0300-9084(23)00202-X [pii]
AID - 10.1016/j.biochi.2023.08.011 [doi]
PST - ppublish
SO  - Biochimie. 2024 Mar;218:1-7. doi: 10.1016/j.biochi.2023.08.011. Epub 2023 Aug 22.