PMID- 37612106
OWN - NLM
STAT- MEDLINE
DCOM- 20230825
LR  - 20230827
IS  - 2044-6055 (Electronic)
IS  - 2044-6055 (Linking)
VI  - 13
IP  - 8
DP  - 2023 Aug 23
TI  - Comparison of BioLIFT versus LIFT for the treatment of trans-sphincteric anal 
      fistula: a protocol for systematic review and meta-analysis.
PG  - e065876
LID - 10.1136/bmjopen-2022-065876 [doi]
LID - e065876
AB  - INTRODUCTION: Identifying the optimal treatment for anal fistula has been 
      challenging. Since first reported in 2007, the ligation of the intersphincteric 
      fistula tract (LIFT) procedure has reported healing rates between 40% and 95% and 
      is being increasingly adopted. The BioLIFT is an augmentation of the LIFT with an 
      intersphincteric bioprosthetic mesh and has reported healing rates between 69% 
      and 94%. Despite increased costs and potential complications associated with 
      mesh, the evidence comparing healing rates between BioLIFT and LIFT is unknown. 
      This study details the protocol for a systematic review and meta-analysis of 
      BioLIFT and LIFT to compare outcomes associated with each procedure. METHODS AND 
      ANALYSIS: MEDLINE, EMBASE and the Cochrane Database will be searched from 
      inception using a search strategy designed by an information specialist. 
      Randomised controlled trials, prospective and retrospective cohort studies, 
      consecutive series, cross-sectional studies and case series with more than five 
      patients will be included. Both comparative and single group studies will be 
      included. The eligible population will be adult patients undergoing BioLIFT or 
      LIFT for trans-sphincteric anal fistula. The primary outcome will be primary 
      healing rate. Secondary outcomes will capture secondary healing rate and 
      complications. Abstract, full text and data extraction will be completed 
      independently and in duplicate by two reviewers. Study risk of bias will be 
      assessed using Risk of Bias In Non-randomized Studies - of Interventions and the 
      Risk of Bias (RoB 2.0) tool. Quality of evidence for outcomes will be evaluated 
      using Grading of Recommendations, Assessment, Development and Evaluations 
      criteria. A meta-analysis will be performed using a random-effects inverse 
      variance model. Subgroup and sensitivity analyses will be explored in relation to 
      complex fistula characteristics and patients who have undergone previous LIFT. 
      Heterogeneity will be assessed using the I(2) statistic. ETHICS AND 
      DISSEMINATION: This review does not require research ethics board approval. This 
      study will be completed in September 2022. The findings of this study will be 
      disseminated through peer-reviewed international conferences and journals. 
      PROSPERO REGISTRATION NUMBER: CRD42020127996.
CI  - (c) Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Ahn, Hilalion San
AU  - Ahn HS
AUID- ORCID: 0000-0002-0308-089X
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Hu, Richard
AU  - Hu R
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Gilbert, Richard
AU  - Gilbert R
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Zwiep, Terry
AU  - Zwiep T
AD  - General Surgery, University of Western Ontario, London, Ontario, Canada.
FAU - Moloo, Husein
AU  - Moloo H
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Williams, Lara
AU  - Williams L
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Raiche, Isabelle
AU  - Raiche I
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Boushey, Robin P
AU  - Boushey RP
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Friedlich, Martin
AU  - Friedlich M
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada.
FAU - Musselman, Reilly P
AU  - Musselman RP
AD  - General Surgery, University of Ottawa, Ottawa, Ontario, Canada rmusselman@toh.ca.
LA  - eng
PT  - Journal Article
DEP - 20230823
PL  - England
TA  - BMJ Open
JT  - BMJ open
JID - 101552874
SB  - IM
MH  - Adult
MH  - Humans
MH  - Cross-Sectional Studies
MH  - Prospective Studies
MH  - Retrospective Studies
MH  - Systematic Reviews as Topic
MH  - Meta-Analysis as Topic
MH  - *Inflammation
MH  - *Rectal Fistula/surgery
MH  - Review Literature as Topic
PMC - PMC10450130
OTO - NOTNLM
OT  - Adult surgery
OT  - Colorectal surgery
OT  - Gastrointestinal infections
OT  - SURGERY
COIS- Competing interests: None declared.
EDAT- 2023/08/24 00:42
MHDA- 2023/08/25 06:42
PMCR- 2023/08/23
CRDT- 2023/08/23 21:14
PHST- 2023/08/25 06:42 [medline]
PHST- 2023/08/24 00:42 [pubmed]
PHST- 2023/08/23 21:14 [entrez]
PHST- 2023/08/23 00:00 [pmc-release]
AID - bmjopen-2022-065876 [pii]
AID - 10.1136/bmjopen-2022-065876 [doi]
PST - epublish
SO  - BMJ Open. 2023 Aug 23;13(8):e065876. doi: 10.1136/bmjopen-2022-065876.