PMID- 37614334
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230825
IS  - 2052-4374 (Print)
IS  - 2052-4374 (Electronic)
IS  - 2052-4374 (Linking)
VI  - 35
DP  - 2023
TI  - Association of heavy metal complex exposure and neurobehavioral function of 
      children.
PG  - e23
LID - 10.35371/aoem.2023.35.e23 [doi]
LID - e23
AB  - BACKGROUND: Exposure to heavy metals is a public health concern worldwide. 
      Previous studies on the association between heavy metal exposure and 
      neurobehavioral functions in children have focused on single exposures and 
      clinical manifestations. However, the present study evaluated the effects of 
      heavy metal complex exposure on subclinical neurobehavioral function using a 
      Korean Computerized Neurobehavior Test (KCNT). METHODS: Urinary mercury, lead, 
      cadmium analyses as well as symbol digit substitution (SDS) and choice reaction 
      time (CRT) tests of the KCNT were conducted in children aged between 10 and 12 
      years. Reaction time and urinary heavy metal levels were analyzed using partial 
      correlation, linear regression, Bayesian kernel machine regression (BKMR), the 
      weighted quantile sum (WQS) regression and quantile G-computation analysis. 
      RESULTS: Participants of 203 SDS tests and 198 CRT tests were analyzed, excluding 
      poor cooperation and inappropriate urine sample. Partial correlation analysis 
      revealed no association between neurobehavioral function and exposure to 
      individual heavy metals. The result of multiple linear regression shows 
      significant positive association between urinary lead, mercury, and CRT. BMKR, 
      WQS regression and quantile G-computation analysis showed a statistically 
      significant positive association between complex urinary heavy metal 
      concentrations, especially lead and mercury, and reaction time. CONCLUSIONS: 
      Assuming complex exposures, urinary heavy metal concentrations showed a 
      statistically significant positive association with CRT. These results suggest 
      that heavy metal complex exposure during childhood should be evaluated and 
      managed strictly.
CI  - Copyright (c) 2023 Korean Society of Occupational & Environmental Medicine.
FAU - Kim, Minkeun
AU  - Kim M
AUID- ORCID: 0000-0002-2857-6277
AD  - Department of Occupational and Environmental Medicine, Yeungnam University 
      Medical Center, Daegu, Korea.
FAU - Park, Chulyong
AU  - Park C
AUID- ORCID: 0000-0001-8584-5376
AD  - Department of Occupational and Environmental Medicine, Yeungnam University 
      Medical Center, Daegu, Korea.
AD  - Department of Preventive Medicine and Public Health, College of Medicine, 
      Yeungnam University, Daegu, Korea.
FAU - Sakong, Joon
AU  - Sakong J
AUID- ORCID: 0000-0003-3623-7619
AD  - Department of Occupational and Environmental Medicine, Yeungnam University 
      Medical Center, Daegu, Korea.
AD  - Department of Preventive Medicine and Public Health, College of Medicine, 
      Yeungnam University, Daegu, Korea.
FAU - Ye, Shinhee
AU  - Ye S
AUID- ORCID: 0000-0003-4238-130X
AD  - Occupational Safety and Health Research Institute, Korea Occupational Safety and 
      Health Agency, Incheon, Korea.
FAU - Son, So Young
AU  - Son SY
AUID- ORCID: 0000-0001-5162-9739
AD  - Department of Occupational and Environmental Medicine, Yeungnam University 
      Medical Center, Daegu, Korea.
FAU - Baek, Kiook
AU  - Baek K
AUID- ORCID: 0000-0003-2822-8480
AD  - Department of Occupational and Environmental Medicine, Yeungnam University 
      Medical Center, Daegu, Korea.
LA  - eng
PT  - Journal Article
DEP - 20230706
PL  - Korea (South)
TA  - Ann Occup Environ Med
JT  - Annals of occupational and environmental medicine
JID - 101609244
PMC - PMC10442582
OTO - NOTNLM
OT  - Central nervous system
OT  - Environmental exposure
OT  - Heavy metals
OT  - Neurobehavioral manifestation
COIS- Competing interests: The authors declare that they have no competing interests.
EDAT- 2023/08/24 06:42
MHDA- 2023/08/24 06:43
PMCR- 2023/07/06
CRDT- 2023/08/24 03:59
PHST- 2022/12/21 00:00 [received]
PHST- 2023/04/26 00:00 [revised]
PHST- 2023/05/19 00:00 [revised]
PHST- 2023/05/20 00:00 [accepted]
PHST- 2023/08/24 06:43 [medline]
PHST- 2023/08/24 06:42 [pubmed]
PHST- 2023/08/24 03:59 [entrez]
PHST- 2023/07/06 00:00 [pmc-release]
AID - 10.35371/aoem.2023.35.e23 [doi]
PST - epublish
SO  - Ann Occup Environ Med. 2023 Jul 6;35:e23. doi: 10.35371/aoem.2023.35.e23. 
      eCollection 2023.