PMID- 37615068
OWN - NLM
STAT- Publisher
LR  - 20230824
IS  - 1940-1574 (Electronic)
IS  - 0003-3197 (Linking)
DP  - 2023 Aug 24
TI  - Clinical Outcomes of Patients With Cholesterol Crystal Embolism Accompanied by 
      Lower Extremity Wound.
PG  - 33197231195671
LID - 10.1177/00033197231195671 [doi]
AB  - Cholesterol crystal embolism (CCE) accompanied by a lower extremity wound is 
      occasionally difficult to differentiate from chronic limb-threatening ischemia 
      (CLTI) and treat. The present multi-center retrospective observational study 
      investigated the clinical characteristics and prognosis of CCE with lower 
      extremity wounds. Consecutive patients (n = 58) clinically diagnosed as CCE with 
      lower extremity wounds between April 2010 and December 2019 were studied. CCE was 
      diagnosed using histological findings, foot condition, renal impairment, and 
      eosinophilia. The primary outcome was 1-year wound healing rate. Patients with 
      CCE were compared with 1309 patients diagnosed with CLTI with tissue loss during 
      the same study period. The CCE group had a significantly more severe Wound, 
      Ischemia, and foot Infection (WIfI) classification compared with the CLTI group. 
      After Kaplan-Meier analysis, the CCE group had a similar 1-year wound healing 
      (55.1 vs 58.3%, P = .096) as the CLTI group. In multivariate stratified Cox 
      regression analysis by WIfI stages, CCE was significantly associated with poor 
      wound healing compared with CLTI [hazard ratio .36 (95% confidence interval 
      .21-.62)]. In conclusion, among the similar WIfI clinical stages, wound healing 
      was significantly worse in the CCE group than in the CLTI group.
FAU - Hata, Yosuke
AU  - Hata Y
AUID- ORCID: 0000-0001-5482-3502
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Iida, Osamu
AU  - Iida O
AUID- ORCID: 0000-0001-6829-7304
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Okamoto, Shin
AU  - Okamoto S
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Ishihara, Takayuki
AU  - Ishihara T
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Nanto, Kiyonori
AU  - Nanto K
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Tsujimura, Takuya
AU  - Tsujimura T
AUID- ORCID: 0000-0002-3128-1357
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Higashino, Naoko
AU  - Higashino N
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Toyoshima, Taku
AU  - Toyoshima T
AUID- ORCID: 0000-0003-1590-5227
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Nakao, Sho
AU  - Nakao S
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
FAU - Fukunaga, Masashi
AU  - Fukunaga M
AD  - Department of Cardiology, Morinomiya Hospital, Osaka, Japan. RINGGOLD: 97839
FAU - Kawasaki, Daizo
AU  - Kawasaki D
AD  - Department of Cardiology, Morinomiya Hospital, Osaka, Japan. RINGGOLD: 97839
FAU - Fujihara, Masahiko
AU  - Fujihara M
AD  - Department of Cardiology, Kishiwada Tokushukai Hospital, Kishiwada, Japan. 
      RINGGOLD: 13737
FAU - Takahara, Mitsuyoshi
AU  - Takahara M
AD  - Department of Diabetes Care Medicine, Osaka University Graduate School of 
      Medicine, Suita, Japan. RINGGOLD: 38637
FAU - Mano, Toshiaki
AU  - Mano T
AD  - Cardiovascular Center, Kansai Rosai Hospital, Amagasaki, Japan. RINGGOLD: 38654
LA  - eng
PT  - Journal Article
DEP - 20230824
PL  - United States
TA  - Angiology
JT  - Angiology
JID - 0203706
SB  - IM
OTO - NOTNLM
OT  - cholesterol crystal embolism
OT  - chronic limb-threatening ischemia
OT  - tissue loss
OT  - wound healing
EDAT- 2023/08/24 06:42
MHDA- 2023/08/24 06:42
CRDT- 2023/08/24 04:23
PHST- 2023/08/24 06:42 [medline]
PHST- 2023/08/24 06:42 [pubmed]
PHST- 2023/08/24 04:23 [entrez]
AID - 10.1177/00033197231195671 [doi]
PST - aheadofprint
SO  - Angiology. 2023 Aug 24:33197231195671. doi: 10.1177/00033197231195671.