PMID- 37615383
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1460-2202 (Electronic)
IS  - 0271-3683 (Linking)
VI  - 48
IP  - 12
DP  - 2023 Dec
TI  - Analysis of Cytokine Levels Based on Optical Coherence Tomography Findings in 
      Acute and Chronic Central Serous Chorioretinopathy.
PG  - 1153-1159
LID - 10.1080/02713683.2023.2250584 [doi]
AB  - Purpose: To investigate the characteristics of optical coherence tomography (OCT) 
      and aqueous humor cytokine differences between acute and chronic central serous 
      chorioretinopathy (CSC) and to evaluate the relevance of these findings.Methods: 
      This was a cross-sectional, observational study. Patients with CSC were divided 
      into acute and chronic groups based on the symptom duration and were compared 
      with normal controls. Best-corrected visual acuity (BCVA), central macular 
      thickness (CMT), subfoveal choroidal thickness (CT), hyperreflective foci (HF), 
      and cytokines including vascular endothelial growth factor (VEGF), interleukin 
      (IL)-6, IL-8, IL-10, interferon-inducible protein-10 (IP-10), and monocyte 
      chemoattractant protein-1 (MCP-1) were used as comparison metrics.Results: A 
      total of 62 patients (62 eyes) with CSC (22 with acute CSC and 40 with chronic 
      CSC) and 35 patients as controls were included in this study. The chronic CSC 
      group had significantly older average ages and worse BCVA than the acute CSC 
      group (both p < 0.05). Both CSC groups showed significant increases in CMT and CT 
      (both p < 0.05). In chronic CSC, the CMT was thinner, with more HF in the 
      neuroretina (p = 0.034). VEGF levels were significantly higher in patients with 
      chronic CSC than in those with acute CSC and controls (p < 0.05). The levels of 
      inflammatory cytokines showed no significant difference between the CSC and 
      control groups. Spearman's correlation analysis showed that the number of HF was 
      positively correlated with disease duration (r = 0.311, p = 0.014), logMAR BCVA 
      (r = 0.487, P < 0.001) and MCP-1 levels (r = 0.256, p = 0.045).Conclusions: 
      Chronicity of CSC could lead to upregulation of VEGF. HF was associated with a 
      more severe visual impairment in CSC patients and had relations with the levels 
      of MCP-1.
FAU - Zhang, Caiyun
AU  - Zhang C
AD  - Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
AD  - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical 
      University, Wenzhou, Zhejiang, P.R. China.
FAU - Mao, Jianbo
AU  - Mao J
AD  - Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
AD  - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical 
      University, Wenzhou, Zhejiang, P.R. China.
FAU - Zhang, Shian
AU  - Zhang S
AD  - Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
FAU - Zheng, Zicheng
AU  - Zheng Z
AD  - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical 
      University, Wenzhou, Zhejiang, P.R. China.
FAU - Zhang, Zhengxi
AU  - Zhang Z
AD  - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical 
      University, Wenzhou, Zhejiang, P.R. China.
FAU - Xiang, Ziyi
AU  - Xiang Z
AD  - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical 
      University, Wenzhou, Zhejiang, P.R. China.
FAU - Chen, Yiqi
AU  - Chen Y
AD  - Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
FAU - Shen, Lijun
AU  - Shen L
AUID- ORCID: 0000-0002-7518-2932
AD  - Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang, P.R. China.
AD  - Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical 
      University, Wenzhou, Zhejiang, P.R. China.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20230827
PL  - England
TA  - Curr Eye Res
JT  - Current eye research
JID - 8104312
RN  - 0 (Vascular Endothelial Growth Factor A)
RN  - 0 (Cytokines)
SB  - IM
MH  - Humans
MH  - *Central Serous Chorioretinopathy/diagnosis
MH  - Vascular Endothelial Growth Factor A
MH  - Tomography, Optical Coherence/methods
MH  - Cytokines/metabolism
MH  - Cross-Sectional Studies
MH  - Chronic Disease
MH  - Fluorescein Angiography/methods
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Central serous chorioretinopathy
OT  - aqueous humor
OT  - cytokine
OT  - hyperreflective foci
OT  - spectral-domain optical coherence tomography
EDAT- 2023/08/24 13:43
MHDA- 2023/12/17 09:44
CRDT- 2023/08/24 08:23
PHST- 2023/12/17 09:44 [medline]
PHST- 2023/08/24 13:43 [pubmed]
PHST- 2023/08/24 08:23 [entrez]
AID - 10.1080/02713683.2023.2250584 [doi]
PST - ppublish
SO  - Curr Eye Res. 2023 Dec;48(12):1153-1159. doi: 10.1080/02713683.2023.2250584. Epub 
      2023 Aug 27.