PMID- 3761568
OWN - NLM
STAT- MEDLINE
DCOM- 19861120
LR  - 20190824
IS  - 0021-4868 (Print)
IS  - 0021-4868 (Linking)
VI  - 27
IP  - 3
DP  - 1986 May
TI  - Peculiar mitral valve and papillary muscle lesions induced by vagus manipulations 
      in rabbits. An experimental model for nonrheumatic mitral regurgitation.
PG  - 377-86
AB  - Peculiar lesions of mitral valves and papillary muscles developed in 50 to 80% of 
      rabbits after clipping (N = 38), crushing (N = 15) or electrical stimulation (N = 
      44) of their cervical vagi. Both right and left vagus manipulations induced 
      similar cardiac lesions. The earliest manifestation was bleeding of the mitral 
      leaflets, which was followed by swelling and fibrosis of the papillary muscles. 
      Ventricular arrhythmias and systolic murmurs were frequently associated with the 
      vagus manipulations. During or just after electrical stimulation of the vagus, 
      ventricular premature contractions (VPCs) were observed in 30 of 44 animals. 
      Twenty-nine of these 30 animals with VPCs (96.7%) were found to have mitral valve 
      and/or papillary muscle lesions at autopsy, whereas only 5 of 14 animals without 
      VPCs (35.7%) had the cardiac lesions. These results indicate that the occurrence 
      of these ventricular arrhythmias during vagus manipulations was closely related 
      with the mitral valve and papillary muscle lesions.
FAU - Imataka, K
AU  - Imataka K
FAU - Yamaoki, K
AU  - Yamaoki K
FAU - Seki, A
AU  - Seki A
FAU - Takayama, Y
AU  - Takayama Y
FAU - Fujii, J
AU  - Fujii J
LA  - eng
PT  - Journal Article
PL  - Japan
TA  - Jpn Heart J
JT  - Japanese heart journal
JID - 0401175
SB  - IM
MH  - Animals
MH  - Arrhythmias, Cardiac/etiology
MH  - Cardiomyopathies/etiology
MH  - *Disease Models, Animal
MH  - Male
MH  - Mitral Valve Insufficiency/*etiology
MH  - Papillary Muscles
MH  - *Rabbits
MH  - Vagus Nerve/*physiology
EDAT- 1986/05/01 00:00
MHDA- 1986/05/01 00:01
CRDT- 1986/05/01 00:00
PHST- 1986/05/01 00:00 [pubmed]
PHST- 1986/05/01 00:01 [medline]
PHST- 1986/05/01 00:00 [entrez]
AID - 10.1536/ihj.27.377 [doi]
PST - ppublish
SO  - Jpn Heart J. 1986 May;27(3):377-86. doi: 10.1536/ihj.27.377.