PMID- 37615855
OWN - NLM
STAT- MEDLINE
DCOM- 20231010
LR  - 20231018
IS  - 1097-0274 (Electronic)
IS  - 0271-3586 (Linking)
VI  - 66
IP  - 11
DP  - 2023 Nov
TI  - Biomarkers related to silicosis and pulmonary function in individuals exposed to 
      silica.
PG  - 984-995
LID - 10.1002/ajim.23528 [doi]
AB  - BACKGROUND: The identification of markers that can facilitate the early diagnosis 
      of silicosis has remained challenging. We evaluated the association of 
      inflammatory markers with the presence of silicosis and lung function impairment 
      in individuals exposed to silica. METHODS: Individuals exposed and not exposed to 
      silica were assessed by occupational history, clinical findings, lung function, 
      chest imaging findings, and inflammatory markers. RESULTS: Among 297 men 
      evaluated, 51 were unexposed controls (G1), 149 were exposed to silica without 
      silicosis (G2), and 97 were exposed to silica with silicosis (G3). Inflammatory 
      marker levels were higher in G3 than in G2 and G1. Platelet/lymphocyte ratio 
      (PLR), lactate dehydrogenase (LDH), soluble tumor necrosis factor II (sTNFRII), 
      and macrophage inflammatory protein-4 (MIP-4) were associated with silicosis, and 
      LDH, neutrophil/lymphocyte ratio (NLR), sTNFRII, monocyte chemoattractant 
      protein-1 (MCP-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), and 
      fibrinogen were negatively associated with lung function. CONCLUSION: Blood 
      inflammatory markers are associated with silicosis and impaired lung function.
CI  - (c) 2023 Wiley Periodicals LLC.
FAU - Lombardi, Elisa M S
AU  - Lombardi EMS
AUID- ORCID: 0000-0003-2955-7710
AD  - Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas 
      HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Mizutani, Rafael F
AU  - Mizutani RF
AD  - Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas 
      HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Terra-Filho, Mario
AU  - Terra-Filho M
AD  - Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
FAU - Ubiratan de Paula, Santos
AU  - Ubiratan de Paula S
AD  - Divisao de Pneumologia, Instituto do Coracao (InCor), Hospital das Clinicas 
      HCFMUSP, Faculdade de Medicina, Universidade de Sao Paulo, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20230824
PL  - United States
TA  - Am J Ind Med
JT  - American journal of industrial medicine
JID - 8101110
RN  - 7631-86-9 (Silicon Dioxide)
RN  - 0 (Biomarkers)
RN  - 0 (Tumor Necrosis Factor-alpha)
SB  - IM
MH  - Male
MH  - Humans
MH  - *Silicon Dioxide/toxicity
MH  - *Silicosis
MH  - Lung
MH  - Biomarkers
MH  - Tumor Necrosis Factor-alpha
OTO - NOTNLM
OT  - inflammatory markers
OT  - lung function
OT  - pneumoconiosis
OT  - silica
OT  - silicosis
EDAT- 2023/08/24 13:43
MHDA- 2023/10/10 06:41
CRDT- 2023/08/24 11:13
PHST- 2023/06/21 00:00 [revised]
PHST- 2023/02/22 00:00 [received]
PHST- 2023/08/06 00:00 [accepted]
PHST- 2023/10/10 06:41 [medline]
PHST- 2023/08/24 13:43 [pubmed]
PHST- 2023/08/24 11:13 [entrez]
AID - 10.1002/ajim.23528 [doi]
PST - ppublish
SO  - Am J Ind Med. 2023 Nov;66(11):984-995. doi: 10.1002/ajim.23528. Epub 2023 Aug 24.