PMID- 37616045 OWN - NLM STAT- MEDLINE DCOM- 20231122 LR - 20231122 IS - 1751-2980 (Electronic) IS - 1751-2972 (Linking) VI - 24 IP - 10 DP - 2023 Oct TI - Clinical and laboratory predictors and prevalence of immune reconstitution inflammatory syndrome in patients with Whipple's disease. PG - 516-521 LID - 10.1111/1751-2980.13223 [doi] AB - OBJECTIVES: Whipple's disease (WD) is a rare and potentially fatal infectious disease caused by Tropheryma whipplei. It is characterized by a long prodromal phase that mimics a rheumatological disease, often leading to immunosuppressant treatment. Immune reconstitution inflammatory syndrome (IRIS) is currently the most important complication of WD, requiring prompt recognition and treatment as it can be fatal. However, epidemiological data on IRIS are scarce. We aimed to identify the clinical and laboratory predictors of IRIS at WD diagnosis and to evaluate whether the prevalence of IRIS has changed over time. METHODS: Forty-five patients with WD (mean age 52 +/- 11 years; 10 females) were followed up between January 2000 and December 2021. Clinical and laboratory data at WD diagnosis were retrospectively collected and compared among patients who developed IRIS and those who did not. RESULTS: Erythrocyte sedimentation rate (ESR; 33.4 +/- 11.8 mm/h vs 67.1 +/- 26.3 mm/h, P < 0.01), platelet (PLT; 234 x 10(9) /L vs 363 x 10(9) /L, P < 0.01), and body mass index (22.0 +/- 2.0 kg/m(2) vs 19.8 +/- 3.0 kg/m(2) , P = 0.04) differed significantly between patients who subsequently developed IRIS and those who did not. ROC analysis identified ESR