PMID- 37620282
OWN - NLM
STAT- MEDLINE
DCOM- 20240424
LR  - 20240428
IS  - 2542-5641 (Electronic)
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 137
IP  - 8
DP  - 2024 Apr 20
TI  - Serum 25-hydroxyvitamin D, genetic susceptibility, and the risk of incident type 
      2 diabetes: A prospective cohort in East China.
PG  - 972-979
LID - 10.1097/CM9.0000000000002794 [doi]
AB  - BACKGROUND: The serum vitamin D level varies widely by population, and studies 
      have linked vitamin D levels with the risk of type 2 diabetes mellitus (T2DM). 
      However, the relationship is inconsistent and the impact of vitamin D on T2DM 
      among East Chinese adults is unclear. The study aimed to investigate the 
      association between serum 25-hydroxyvitamin D (25[OH]D) levels and the risk of 
      T2DM and evaluated whether the association is modified by genetic predisposition. 
      METHODS: In the Survey on Prevalence in East China for Metabolic Diseases and 
      Risk Factors (SPECT-China) cohort, 1862 participants free of T2DM at baseline 
      were included. A weighted genetic risk score was calculated with 28 variants 
      associated with T2DM. Hierarchical logistic models were used to examine the 
      association of serum 25(OH)D and genetic risk with T2DM. RESULTS: After a 5-year 
      follow-up, 132 cases of T2DM were documented. We observed no significant 
      association between quartiles of serum 25(OH)D and T2DM risk after multivariable 
      adjustment (chi 2 = 0.571, Pfor trend = 0.426). Compared to those in the lowest 
      quartile of 25(OH)D, the odds ratios (ORs) (95% confidence interval [CI]) for 
      participants with increased quartiles were 1.29 (0.74-2.25), 1.35 (0.77-2.36), 
      and 1.27 (0.72-2.24), respectively. We observed a positive association of 
      glycated hemoglobin (HbA1c) with 25(OH)D at baseline (beta = 1.752, P = 0.001) and 
      after follow-up (beta = 1.385, P = 0.003), and a negative association of ln 
      conversion homeostasis model assessment (HOMA)-beta with 25(OH)D at baseline (beta = 
      -0.982, P = 0.021). There was no significant interaction between 25(OH)D and 
      diabetes genetic predisposition on the risk of T2DM (chi 2 = 2.710, Pfor 
      interaction = 0.100). The lowest OR (95% CI) of T2DM was among participants with 
      low genetic risk and the highest quartile of 25(OH)D (0.17 [0.05-0.62]). 
      CONCLUSION: Serum 25(OH)D may be irrelevant to the risk of incident T2DM among 
      East Chinese adults regardless of genetic predisposition.
CI  - Copyright (c) 2024 The Chinese Medical Association, produced by Wolters Kluwer, 
      Inc. under the CC-BY-NC-ND license.
FAU - Sun, Ying
AU  - Sun Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, 
      China.
FAU - Zhang, Haojie
AU  - Zhang H
AD  - Department of Endocrinology and Metabolism and Department of Guideline and Rapid 
      Recommendation, Cochrane China Center, MAGIC China Center, Chinese Evidence-Based 
      Medicine Center, West China Hospital, Sichuan University, Chengdu, Sichuan 
      610041, China.
FAU - Wang, Bin
AU  - Wang B
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, 
      China.
FAU - Wang, Yuying
AU  - Wang Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, 
      China.
FAU - Chen, Chi
AU  - Chen C
AD  - Department of Endocrinology, Shuguang Hospital Affiliated to Shanghai University 
      of Traditional Chinese Medicine, Shanghai 201203, China.
FAU - Chen, Yi
AU  - Chen Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, 
      China.
FAU - Lu, Yingli
AU  - Lu Y
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, 
      China.
FAU - Wang, Ningjian
AU  - Wang N
AD  - Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People's 
      Hospital, Shanghai JiaoTong University School of Medicine, Shanghai 200011, 
      China.
LA  - eng
PT  - Journal Article
DEP - 20230824
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 1406-16-2 (Vitamin D)
RN  - A288AR3C9H (25-hydroxyvitamin D)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/genetics/blood/epidemiology
MH  - *Vitamin D/blood/*analogs & derivatives
MH  - China/epidemiology
MH  - Female
MH  - Male
MH  - Middle Aged
MH  - *Genetic Predisposition to Disease
MH  - Prospective Studies
MH  - Adult
MH  - Risk Factors
MH  - Aged
PMC - PMC11046023
COIS- None.
EDAT- 2023/08/25 00:41
MHDA- 2024/04/24 19:06
PMCR- 2024/04/20
CRDT- 2023/08/24 22:23
PHST- 2023/02/11 00:00 [received]
PHST- 2024/04/24 19:06 [medline]
PHST- 2023/08/25 00:41 [pubmed]
PHST- 2023/08/24 22:23 [entrez]
PHST- 2024/04/20 00:00 [pmc-release]
AID - 00029330-990000000-00768 [pii]
AID - CMJ-2022-2822 [pii]
AID - 10.1097/CM9.0000000000002794 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2024 Apr 20;137(8):972-979. doi: 10.1097/CM9.0000000000002794. 
      Epub 2023 Aug 24.