PMID- 37620427
OWN - NLM
STAT- MEDLINE
DCOM- 20240221
LR  - 20240222
IS  - 1476-5608 (Electronic)
IS  - 1365-7852 (Linking)
VI  - 27
IP  - 1
DP  - 2024 Mar
TI  - Real-world four-year functional and surgical outcomes of Rezum therapy in younger 
      versus elderly men.
PG  - 109-115
LID - 10.1038/s41391-023-00703-0 [doi]
AB  - BACKGROUND: Management of urinary symptoms in elderly patients with benign 
      prostatic hyperplasia (BPH) is complex given challenges with medications and 
      invasive surgeries. Rezum, a minimally invasive water vapor therapy, is an 
      emerging alternative. We compare real-world Rezum outcomes between young and 
      elderly patients over 4 years. METHODS: We retrospectively analyzed a multiethnic 
      population treated with Rezum at a single center between 2017-2019. Patients were 
      stratified into young (<65 years) or elderly (>/=65 years) cohorts. International 
      Prostate Symptom Score (IPSS), Quality of Life (QoL), maximum urinary flow rate 
      (Qmax), decisional regret scores, and adverse events (AEs) were assessed at 
      baseline, 1-, 3-, 6-, 12-, and/or 48-months. Descriptive statistics were compared 
      using t-tests, Chi-squared, or Mann-Whitney U tests. Changes in outcomes were 
      assessed using Wilcoxon signed-rank tests, stratified by age. RESULTS: 256 
      patients - 146 (57%) young and 110 (43%) elderly - were included. The majority 
      were Asian (33.2%) or non-Hispanic Black (28.9%). Significant improvements were 
      observed in the combined cohort at 4-years in IPSS, QoL, and Qmax when compared 
      to baseline (all p < 0.05). Between the age cohorts, there were no significant 
      differences in IPSS, QoL, or Qmax at any follow-up. Within both cohorts, 
      significant improvements in IPSS and QoL were found from baseline to all 
      follow-ups. In the young cohort, Qmax was significantly improved from baseline to 
      all follow-ups while in the elderly cohort, this was observed only at the 3-month 
      follow-up. No significant differences in AEs or regret was found between cohorts. 
      There was no significant difference in 4-year surgical retreatment rates between 
      cohorts (elderly 4.0% vs young 4.4%, p = 0.86). CONCLUSIONS: There were no 
      significant differences in IPSS, QoL, or AEs between elderly and younger men over 
      4 years following Rezum, suggesting comparable benefits and risks. Future 
      research is warranted to clarify the impact of Rezum on Qmax in elderly men.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature Limited.
FAU - Zhu, Michael
AU  - Zhu M
AUID- ORCID: 0000-0001-5675-6403
AD  - Albert Einstein College of Medicine, Bronx, NY, USA. Michael.Zhu@einsteinmed.edu.
FAU - Babar, Mustufa
AU  - Babar M
AUID- ORCID: 0000-0001-8490-2260
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Hawks-Ladds, Noah
AU  - Hawks-Ladds N
AUID- ORCID: 0009-0000-7826-7942
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Tawfik, Marc-Mina
AU  - Tawfik MM
AUID- ORCID: 0000-0002-7228-3682
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Loloi, Justin
AU  - Loloi J
AD  - Department of Urology, Montefiore Medical Center, Bronx, NY, USA.
FAU - Labagnara, Kevin
AU  - Labagnara K
AUID- ORCID: 0000-0003-3275-1004
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Sayed, Rahman
AU  - Sayed R
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Tang, Kevin
AU  - Tang K
AUID- ORCID: 0000-0002-2908-1954
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Salami, Azizou
AU  - Salami A
AD  - Albert Einstein College of Medicine, Bronx, NY, USA.
FAU - Singh, Sandeep
AU  - Singh S
AD  - DSS Urology, Queens Village, New York, NY, USA.
FAU - Singh, Jaskirat
AU  - Singh J
AD  - DSS Urology, Queens Village, New York, NY, USA.
FAU - Ines, Matthew
AU  - Ines M
AUID- ORCID: 0000-0003-0364-7398
AD  - DSS Urology, Queens Village, New York, NY, USA.
FAU - Iqbal, Nazifa
AU  - Iqbal N
AD  - DSS Urology, Queens Village, New York, NY, USA.
FAU - Ciatto, Michael
AU  - Ciatto M
AD  - DSS Urology, Queens Village, New York, NY, USA.
LA  - eng
PT  - Journal Article
DEP - 20230824
PL  - England
TA  - Prostate Cancer Prostatic Dis
JT  - Prostate cancer and prostatic diseases
JID - 9815755
SB  - IM
MH  - Male
MH  - Humans
MH  - Aged
MH  - Quality of Life
MH  - *Lower Urinary Tract Symptoms/epidemiology
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - *Prostatic Neoplasms
MH  - *Prostatic Hyperplasia/surgery
EDAT- 2023/08/25 00:41
MHDA- 2024/02/21 11:15
CRDT- 2023/08/24 23:27
PHST- 2023/04/19 00:00 [received]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/07/10 00:00 [revised]
PHST- 2024/02/21 11:15 [medline]
PHST- 2023/08/25 00:41 [pubmed]
PHST- 2023/08/24 23:27 [entrez]
AID - 10.1038/s41391-023-00703-0 [pii]
AID - 10.1038/s41391-023-00703-0 [doi]
PST - ppublish
SO  - Prostate Cancer Prostatic Dis. 2024 Mar;27(1):109-115. doi: 
      10.1038/s41391-023-00703-0. Epub 2023 Aug 24.