PMID- 37620614
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231122
IS  - 2509-2723 (Electronic)
IS  - 2509-2715 (Print)
IS  - 2509-2723 (Linking)
VI  - 45
IP  - 6
DP  - 2023 Dec
TI  - Association between aging-related biomarkers and longitudinal trajectories of 
      intrinsic capacity in older adults.
PG  - 3409-3418
LID - 10.1007/s11357-023-00906-2 [doi]
AB  - Intrinsic capacity (IC), the composite of physical and mental capacities, 
      declines with age at different rates and patterns between individuals. We aimed 
      to investigate the association between longitudinal IC trajectories and plasma 
      biomarkers of two hallmarks of aging-chronic inflammation and mitochondrial 
      dysfunction-in older adults. From the Multidomain Alzheimer Preventive Trial 
      (MAPT), we included 1271 community-dwelling older people (mean [SD] age = 76.0 
      [4.3] years) with IC data over four years. Group-based multi-trajectory modeling 
      was performed to identify clusters of the participants with similar longitudinal 
      patterns across four IC domains: cognition, locomotion, psychology, and vitality. 
      Five IC multi-trajectory groups were determined: low in all domains (8.4%), low 
      locomotion (24.6%), low psychological domain (16.7%), robust (i.e., high in all 
      domains except vitality; 28.3%), and robust with high vitality (22.0%). Compared 
      to the best trajectory group (i.e., robust with high vitality), elevated levels 
      of plasma interleukin-6 (IL-6), tumor necrosis factor receptor-1 (TNFR-1), and 
      growth differentiation factor-15 (GDF-15) were associated with a higher risk of 
      belonging to the "low in all domains" group (IL-6: relative risk ratio (RRR) [95% 
      CI] = 1.42 [1.07 - 1.88]; TNFR-1: RRR = 1.46 [1.09 - 1.96]; GDF-15: RRR = 1.99 
      [1.45 - 2.73]). Higher IL-6 and GDF-15 also increased the risk of being in the 
      "low locomotion" group. GDF-15 outperformed other biomarkers by showing the 
      strongest associations with IC trajectory groups. Our findings found that plasma 
      biomarkers reflecting inflammation and mitochondrial impairment distinguished 
      older people with multi-impaired IC trajectories from those with high-stable IC.
CI  - (c) 2023. The Author(s), under exclusive licence to American Aging Association.
FAU - Lu, Wan-Hsuan
AU  - Lu WH
AUID- ORCID: 0000-0001-7824-4214
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), 31000, Toulouse, France. wan-hsuan.lu1@univ-tlse3.fr.
AD  - Maintain Aging Research team, Centre d'Epidemiologie et de Recherche en sante des 
      POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France. 
      wan-hsuan.lu1@univ-tlse3.fr.
FAU - Guyonnet, Sophie
AU  - Guyonnet S
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), 31000, Toulouse, France.
AD  - Maintain Aging Research team, Centre d'Epidemiologie et de Recherche en sante des 
      POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France.
FAU - Martinez, Laurent O
AU  - Martinez LO
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), UMR 1297, 
      Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
FAU - Lucas, Alexandre
AU  - Lucas A
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), UMR 1297, 
      Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
FAU - Parini, Angelo
AU  - Parini A
AD  - Institut National de la Sante et de la Recherche Medicale (INSERM), UMR 1297, 
      Institute of Metabolic and Cardiovascular Diseases, Toulouse, France.
FAU - Vellas, Bruno
AU  - Vellas B
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), 31000, Toulouse, France.
AD  - Maintain Aging Research team, Centre d'Epidemiologie et de Recherche en sante des 
      POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France.
FAU - de Souto Barreto, Philipe
AU  - de Souto Barreto P
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), 31000, Toulouse, France.
AD  - Maintain Aging Research team, Centre d'Epidemiologie et de Recherche en sante des 
      POPulations (CERPOP), Inserm, Universite Paul Sabatier, Toulouse, France.
LA  - eng
PT  - Journal Article
DEP - 20230824
PL  - Switzerland
TA  - Geroscience
JT  - GeroScience
JID - 101686284
RN  - 0 (Growth Differentiation Factor 15)
RN  - 0 (Interleukin-6)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Humans
MH  - Aged
MH  - *Growth Differentiation Factor 15
MH  - *Alzheimer Disease/psychology
MH  - Interleukin-6
MH  - Prospective Studies
MH  - Aging
MH  - Biomarkers
MH  - Inflammation
PMC - PMC10643641
OTO - NOTNLM
OT  - Biological aging
OT  - Functioning
OT  - Healthy aging
OT  - Inflammaging
COIS- The authors declare no competing interests.
EDAT- 2023/08/25 00:42
MHDA- 2023/11/15 06:43
PMCR- 2023/08/24
CRDT- 2023/08/24 23:36
PHST- 2023/06/23 00:00 [received]
PHST- 2023/08/06 00:00 [accepted]
PHST- 2023/11/15 06:43 [medline]
PHST- 2023/08/25 00:42 [pubmed]
PHST- 2023/08/24 23:36 [entrez]
PHST- 2023/08/24 00:00 [pmc-release]
AID - 10.1007/s11357-023-00906-2 [pii]
AID - 906 [pii]
AID - 10.1007/s11357-023-00906-2 [doi]
PST - ppublish
SO  - Geroscience. 2023 Dec;45(6):3409-3418. doi: 10.1007/s11357-023-00906-2. Epub 2023 
      Aug 24.