PMID- 37620819
OWN - NLM
STAT- MEDLINE
DCOM- 20230828
LR  - 20231118
IS  - 1471-2474 (Electronic)
IS  - 1471-2474 (Linking)
VI  - 24
IP  - 1
DP  - 2023 Aug 24
TI  - The correlation of two bone turnover markers with bone mineral density: a 
      population-based cross-sectional study.
PG  - 675
LID - 10.1186/s12891-023-06613-5 [doi]
LID - 675
AB  - OBJECTIVE: Exploring the correlation between bone turnover marks (BTMs) with 
      lumbar BMD in middle-aged populations. METHODS: The cross-sectional analysis 
      fetched data came from NHANES. The level of serum bone alkaline phosphatase 
      (sBAP) and urinary N-telopeptide (uNTx) were regarded as representative of bone 
      turnover. Lumbar BMD was the outcome of the study. Multivariable linear 
      regression models were utilized to detect the correlation of sBAP and uNTx with 
      Lumbar BMD. RESULTS: The level of sBAP and uNTx was negatively correlated with 
      lumbar BMD in every multivariable linear regression. For sBAP, this inverse 
      correlation was stable in both men and women (P < 0.01). uNTx indicated a 
      negative association after all relevant covariables were adjusted (P < 0.01). The 
      men group remained the negative correlation in gender subgroup analysis 
      (P < 0.01). CONCLUSION: This study indicated that the increased level of sBAP and 
      uNTx associated with lumbar BMD decreased among middle-aged adults. This 
      correlation could prompt researchers to explore further the relationship between 
      bone turnover rate and BMD, which may provide information for the early detection 
      of BMD loss and provide a new strategy for clinical practice.
CI  - (c) 2023. BioMed Central Ltd., part of Springer Nature.
FAU - Wang, Gao-Xiang
AU  - Wang GX
AD  - Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese 
      Medicine, Nanjing, Jiangsu, 210029, China.
AD  - Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, 
      Shenzhen, Guangdong, 518033, China.
FAU - Li, Jun-Tong
AU  - Li JT
AD  - Department of Endocrinology, Affiliated Hospital of Nanjing University of Chinese 
      Medicine, Nanjing, Jiangsu, 210029, China.
AD  - Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, 
      Shenzhen, Guangdong, 518033, China.
FAU - Cai, Fang-Ying
AU  - Cai FY
AD  - Department of Endocrinology, The Fourth Clinical Medical College of Guangzhou 
      University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
FAU - Huang, Bao-Li
AU  - Huang BL
AD  - Department of Endocrinology, The Fourth Clinical Medical College of Guangzhou 
      University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
FAU - Fang, Ze-Bin
AU  - Fang ZB
AD  - Department of Endocrinology, The Fourth Clinical Medical College of Guangzhou 
      University of Chinese Medicine, Shenzhen, Guangdong, 518033, China.
FAU - Zhao, Heng-Xia
AU  - Zhao HX
AD  - Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, 
      Shenzhen, Guangdong, 518033, China.
FAU - Chu, Shu-Fang
AU  - Chu SF
AD  - Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, 
      Shenzhen, Guangdong, 518033, China. chushufanggzhtcm@163.com.
FAU - Liu, De-Liang
AU  - Liu DL
AD  - Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, 
      Shenzhen, Guangdong, 518033, China. ldl2580@gzucm.edu.cn.
FAU - Li, Hui-Lin
AU  - Li HL
AD  - Department of Endocrinology, Shenzhen Traditional Chinese Medicine Hospital, 
      Shenzhen, Guangdong, 518033, China. sztcmlhl@163.com.
LA  - eng
GR  - 82104759/National Natural Science Foundation of China/
GR  - 2019A1515110108/The Natural Science Foundation of Guangdong Provincial/
PT  - Journal Article
DEP - 20230824
PL  - England
TA  - BMC Musculoskelet Disord
JT  - BMC musculoskeletal disorders
JID - 100968565
RN  - EC 3.1.3.1 (Alkaline Phosphatase)
SB  - IM
MH  - Adult
MH  - Male
MH  - Middle Aged
MH  - Female
MH  - Humans
MH  - *Bone Density
MH  - Cross-Sectional Studies
MH  - Nutrition Surveys
MH  - *Alkaline Phosphatase
MH  - Bone Remodeling
PMC - PMC10464322
OTO - NOTNLM
OT  - Bone mineral density
OT  - Bone turnover markers
OT  - Bone-specific alkaline phosphatase
OT  - NHANES
OT  - Urinary N-telopeptide
COIS- The authors stated that no conflicts of interest
EDAT- 2023/08/25 00:42
MHDA- 2023/08/28 06:42
PMCR- 2023/08/24
CRDT- 2023/08/24 23:47
PHST- 2023/03/01 00:00 [received]
PHST- 2023/06/08 00:00 [accepted]
PHST- 2023/08/28 06:42 [medline]
PHST- 2023/08/25 00:42 [pubmed]
PHST- 2023/08/24 23:47 [entrez]
PHST- 2023/08/24 00:00 [pmc-release]
AID - 10.1186/s12891-023-06613-5 [pii]
AID - 6613 [pii]
AID - 10.1186/s12891-023-06613-5 [doi]
PST - epublish
SO  - BMC Musculoskelet Disord. 2023 Aug 24;24(1):675. doi: 10.1186/s12891-023-06613-5.