PMID- 37621212
OWN - NLM
STAT- Publisher
LR  - 20230825
IS  - 1308-5735 (Electronic)
DP  - 2023 Aug 25
TI  - Insulinoma Associated with MEN1 Syndrome: A Case of Persistent Hypoglycemia in 
      School-aged Child.
LID - 10.4274/jcrpe.galenos.2023.2023-3-10 [doi]
AB  - Insulinoma is a rare cause of non-ketotic hypoglycemia both in adults and in 
      children. Pediatric patients account for approximately 5% of all cases, mostly 
      due to isolated benign lesions, but it can also be part of a multiple endocrine 
      neoplasia type 1 syndrome (MEN1). We report the case of a patient with multiple 
      hospitalizations related to hypoglycemia and neuroglycopenia symptoms, with 
      multiple studies demonstrating the presence of an insulinoma as part of the 
      spectrum of MEN1 syndrome. The primary significance of our report is to 
      underscore that insulinoma can present as the initial manifestation of MEN1 
      syndrome in 10% of pediatric patients. Furthermore, we describe a likely 
      pathogenic variant in the MEN1 gene not previously reported in the literature. 
      Our report highlights the importance of the convergence of clinical, biochemical 
      and molecular investigations in establishing a precise diagnosis, prognosis, and 
      appropriate follow-up for pediatric patients with hypoglycemia.
FAU - Lemus-Zepeda, Rodrigo
AU  - Lemus-Zepeda R
AD  - Pediatric Endocrinology. Fundacion Valle del Lili, Cali, Colombia.
FAU - Salazar-Solarte, Aura Maria
AU  - Salazar-Solarte AM
AD  - Pediatrics. Fundacion Valle del Lili, Cali, Colombia.
FAU - Vasquez-Forero, Diana Marcela
AU  - Vasquez-Forero DM
AD  - Genetics Resident, Universidad Icesi, Cali, Colombia.
FAU - Mejia-Zapata, Liliana
AU  - Mejia-Zapata L
AD  - Pediatric Endocrinology. Fundacion Valle del Lili, Cali, Colombia.
FAU - Jr Angulo-Mosquera, Mario
AU  - Jr Angulo-Mosquera M
AD  - Pediatric Endocrinology. Fundacion Valle del Lili, Cali, Colombia.
LA  - eng
PT  - Journal Article
DEP - 20230825
PL  - Turkey
TA  - J Clin Res Pediatr Endocrinol
JT  - Journal of clinical research in pediatric endocrinology
JID - 101519456
SB  - IM
OTO - NOTNLM
OT  - MEN1 syndrome
OT  - hypoglycemia
OT  - insulinoma
OT  - pediatrics
EDAT- 2023/08/25 06:42
MHDA- 2023/08/25 06:42
CRDT- 2023/08/25 03:18
PHST- 2023/08/25 06:42 [medline]
PHST- 2023/08/25 06:42 [pubmed]
PHST- 2023/08/25 03:18 [entrez]
AID - 10.4274/jcrpe.galenos.2023.2023-3-10 [doi]
PST - aheadofprint
SO  - J Clin Res Pediatr Endocrinol. 2023 Aug 25. doi: 
      10.4274/jcrpe.galenos.2023.2023-3-10.