PMID- 37622602
OWN - NLM
STAT- MEDLINE
DCOM- 20231122
LR  - 20231209
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 169
IP  - 6
DP  - 2023 Dec
TI  - Development and Validation of the Parosmia Olfactory Dysfunction Outcomes Rating 
      (DisODOR).
PG  - 1654-1661
LID - 10.1002/ohn.477 [doi]
AB  - OBJECTIVE: Develop and validate a quality-of-life (QoL) outcome measure for 
      patients with dysosmia. STUDY DESIGN: Cross-sectional survey study. SETTING: 
      Otolaryngology clinics, research registries, and Facebook support groups. 
      METHODS: A 59-item pilot survey with questions addressing parosmia concerns was 
      developed using input from subjects with parosmia and clinical expertise from 
      Otolaryngologists. After item reduction, the Parosmia Olfactory Dysfunction 
      Outcomes Rating (DisODOR) was reduced to its final 29 items. DisODOR maximum 
      score is 116 (each item score 0-4) with higher scores indicating a higher degree 
      of dysfunction from smell distortion. DisODOR was validated using participants 
      with parosmia persisting >3 months after severe acute respiratory syndrome 
      coronavirus 2 (cases) and healthy controls. Reliability, face and content 
      validity, internal consistency, convergent validity, discriminative validity, 
      sensitivity to change, and the minimal clinically important difference (MCID) 
      were assessed. RESULTS: A total of 134 cases and 20 controls completed DisODOR. 
      The mean (SD) age was 45.9 (12.2) for cases and 29.6 (8.9) for controls. The mean 
      score difference between cases and controls was 45.0 (95% confidence interval, 
      40.5-49.5) displaying good discriminative validity. DisODOR showed strong 
      test-retest reliability (r = .942) with high internal consistency (Cronbach's 
      alpha = .971). DisODOR had a moderate correlation with SNOT-22 scores (r = .619) 
      indicating good convergent validity. There is an excellent association with the 
      global impression of severity categories (eta(2)  = 0.447). Based on the 
      distribution method, the MCID is 15. CONCLUSION: DisODOR is a valid, reliable 
      QoL instrument for parosmia that can be used to measure the functional impact and 
      QoL impairment for parosmia patients. DisODOR is sensitive to change and thus can 
      be used in studies investigating treatments for parosmia.
CI  - (c) 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.
FAU - Ioerger, Patrick
AU  - Ioerger P
AUID- ORCID: 0000-0003-0086-1006
AD  - Clinical Outcomes Research Office, Department of Otolaryngology-Head and Neck 
      Surgery, Washington University School of Medicine in St Louis, St Louis, 
      Missouri, USA.
AD  - School of Medicine, University of Kansas Medical Center, Kansas City, Kansas, 
      USA.
FAU - Kallogjeri, Dorina
AU  - Kallogjeri D
AUID- ORCID: 0000-0001-5365-0988
AD  - Clinical Outcomes Research Office, Department of Otolaryngology-Head and Neck 
      Surgery, Washington University School of Medicine in St Louis, St Louis, 
      Missouri, USA.
AD  - Department of Otolaryngology-Head and Neck Surgery, Washington University School 
      of Medicine in St Louis, St Louis, Missouri, USA.
FAU - Roland, Lauren
AU  - Roland L
AUID- ORCID: 0000-0003-2036-7611
AD  - Department of Otolaryngology-Head and Neck Surgery, Washington University School 
      of Medicine in St Louis, St Louis, Missouri, USA.
FAU - Schneider, John S
AU  - Schneider JS
AD  - Department of Otolaryngology-Head and Neck Surgery, Washington University School 
      of Medicine in St Louis, St Louis, Missouri, USA.
FAU - Piccirillo, Jay F
AU  - Piccirillo JF
AUID- ORCID: 0000-0002-4062-1747
AD  - Clinical Outcomes Research Office, Department of Otolaryngology-Head and Neck 
      Surgery, Washington University School of Medicine in St Louis, St Louis, 
      Missouri, USA.
AD  - Department of Otolaryngology-Head and Neck Surgery, Washington University School 
      of Medicine in St Louis, St Louis, Missouri, USA.
FAU - Farrell, Nyssa Fox
AU  - Farrell NF
AD  - Department of Otolaryngology-Head and Neck Surgery, Washington University School 
      of Medicine in St Louis, St Louis, Missouri, USA.
LA  - eng
PT  - Journal Article
DEP - 20230825
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Humans
MH  - *Smell
MH  - Quality of Life
MH  - Reproducibility of Results
MH  - Cross-Sectional Studies
MH  - *Olfaction Disorders/diagnosis
OTO - NOTNLM
OT  - Covid-19
OT  - anosmia
OT  - hyposmia
OT  - parosmia
OT  - patient-reported outcome measure
OT  - phantosmia
OT  - smell change
OT  - smell loss
EDAT- 2023/08/25 12:43
MHDA- 2023/11/22 06:42
CRDT- 2023/08/25 07:33
PHST- 2023/06/25 00:00 [revised]
PHST- 2023/05/15 00:00 [received]
PHST- 2023/07/17 00:00 [accepted]
PHST- 2023/11/22 06:42 [medline]
PHST- 2023/08/25 12:43 [pubmed]
PHST- 2023/08/25 07:33 [entrez]
AID - 10.1002/ohn.477 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2023 Dec;169(6):1654-1661. doi: 10.1002/ohn.477. Epub 
      2023 Aug 25.